Bowen's disease is an intraepidermal squarnous cell carcinoma referred to also as squamous cell carcimona in situ. Approximately two-thirds of Bowen's disease consist of solitary lesion while remaining show multiple lesions, We experienced a 68-year old male patient who had multiple erythematous pathes and plaques covered with scales and grayish crusts developing on the trunk and both lower extremities. At first, clinically we suspected psoriasis, seborrheic keratosis, eczema and mycosis fungoides, and finally histopathologic features revealed Bowen's disease showing transformation to invasive squamous cell carcinorna.
Aged ; Bowen's Disease ; Carcinoma, Squamous Cell* ; Eczema ; Humans ; Keratosis, Seborrheic ; Lower Extremity ; Male ; Mycosis Fungoides ; Psoriasis ; Weights and Measures

A 4-year-old boy have had widespread, multiple, dark brownish, verrucous ]papular plaques on the neck, left chest, right side of abdomen, back and penile skin since birth. Clinical features and light and electron microscopic findings were consistent with ichthyosis hystrix. The patient was successfully treated with systemic administration of etretinate and vitamin E.
Abdomen ; Acitretin* ; Child* ; Child, Preschool ; Etretinate* ; Humans ; Ichthyosis* ; Male ; Neck ; Parturition ; Porcupines* ; Skin ; Thorax ; Vitamin E ; Vitamins

No abstract available.
Acanthoma*

A 46-year-old male patient had recurrent episodes of generalized pruritic wheals during hemodialysis. He has experienced urticaria during hemodialysis whenever he used a capillary dialyser sterilized by ethylene oxide(EO, Polysulfone-) gas which is used to sterilize hemodialysers and other medical equipment. On the other hand, capillary dialyser sterilized by Gamma ray (Hemophad) has not evoked urticaria. Although the presence of EO-specific antibodies was not detected, urticarial rash never developed when the equipment was switched to a gamma-sterilized one. We herein report a case referred to ethylene oxide induced cutaneous hypersensitivity during hemodialysis.
Antibodies ; Capillaries ; Ethylene Oxide ; Exanthema ; Gamma Rays ; Hand ; Humans ; Hypersensitivity* ; Kidneys, Artificial ; Male ; Middle Aged ; Renal Dialysis* ; Urticaria

BACKGROUND: The keratinocyte growth factor(KGF) is a recently identified mitogen for epithelial cells produced by nomal stromal fibroblasts. ln the skin, KGF has been shown to stimulate keratinocyte proliferation and differentiatian. Dendritic epidermal T cells(DETC) are skin-specific members of the epithelial y 8 T-cell family that reside normally in the murine epidermis. The DETCs recognize antigen expressed by damaged or diseased neighboring keratinoctyes and consequently secrete cytokines sueh as IFN- y, lL-2, IL-4, GM-CSF. OBJECTIVE: The purpose of this study was to observe the expression of KGF mRNA in keratinocyte and DETC as well as to investigate the cytokine-mediated intercellular communication between kerati- nocyte and DETC. METHODS: Using a RT-PCR(reverse transcription-polymerase chain reaction), we examined the expression of KGF mRNA in keratinocyte and DETC, and compared the level of KGF mRNA between resting and activated DETC with Con-A (concanavalin A).
Cytokines ; Epidermis ; Epithelial Cells ; Fibroblast Growth Factor 7* ; Fibroblasts ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Interleukin-4 ; Keratinocytes* ; RNA, Messenger* ; Skin ; T-Lymphocytes

BACKGROUND: Superficial fungal infections are common diseases acid the prevalence of superficial fungal diseases are not static but change under the influence of various forces such as climate, migration of peoples and development in prophylaxis and therapy. OBJECTIVE: To investigate the present status of superficial dermatiphytoses and some changes on the frequency of the diseases, sex distributions and varieties of the casiative organisms. MEHTODS: The clinical and rnycological aspects of superficial fungal diseases of 3,222 patients from July 1989 to June 1992 were analyzed. Results : 1) The incidence of superficial fungal diseases was 25.4% of total out-patients. 2) The superficial fungal diseases showed a higt incidence in the third(26.4%) and the fourth decade(24.3%). 3) The ratio of male to female was 2.11:1(2,188:1,034). 4) The monthly prevalence of super ficial fungal diseases was high inhuly(17.8%), August(15.2%) and June(1.7%). 5) The incidence of superficial fungal diseases in order of frequency were tinea pedis ,28.1%, tinea cruris(19.5%), onychomycosis(15.6%), tinen orporis(11.5%), tinea manus(7.8%), tinea versicolar(7.8%), candidiasis(7.4%) and tinea capitis(2.3%), 6) Coexisting fungal infections were found in 644 patients(19.9%) and the case of tinea pedis with onychomycosis was the most common. 7) The positive rate of KOH scraping was 54.0% and the positive rate of culture on ordinary Salourauds dextrose agar media was 42.7%. 8) Trichophyton rubr,im was the most common causative orantism of superficial dermatophytes(38.4%), and other in decreasing frequency were Candida albicans(36.9%), Trichophyton mentagrophytes(23.6%) Microsporum canis(0.7%), Trichophyton ferrvgiteum(0.3%) and Epidermophyton floccosum(0.1%). CONCLUSION: These results are not significantly different from those iif previous studies. But the incidence rate of the superficial pungal diseases(25.4%) were higher thar, previous studies and showed a high incidence in young male patients and in the summer. The positiv rate of KOH scraping(54.0%) was lower than previous studies. The most common causative organism was Trichophyton rubrum(38.4 %).
Agar ; Candida ; Climate ; Epidermophyton ; Female ; Glucose ; Humans ; Incidence ; Male ; Microsporum ; Onychomycosis ; Outpatients ; Prevalence ; Sex Distribution ; Tinea ; Tinea Pedis ; Trichophyton

Clinically, the transformation of morphea to scleroderma is rare. We report a case suggested acroselerosis transformed from guttate morphea. Patient was 30-year old woman who had generalized bean-sized depigmented macules except face since early childhood. About one year ago, Raynauds phenomenon, edema and sclerotic change of the both hands and feet were developed. On the laboratory findings, there were positive reaction for rheumatoid factor and antinauclear antibody test and increase of erythrocyte sedimentation rate. Histopathologically, there were even increased collagen fibers, atherosclerotic change of the vessels and atrophic sweat glands.
Adult ; Blood Sedimentation ; Collagen ; Edema ; Female ; Foot ; Hand ; Humans ; Rheumatoid Factor ; Scleroderma, Localized* ; Sweat Glands

Plexiform schwannoma is a relatively rare, benign peripheral nerve sheath tumor that can be located either in the deep soft tissues or in the dermis or subcutaneous tissue. This tumor may occur singly or as multiple lesions and may be localized to one anatomic site or diffusely distributed. Plexiform schwannoma should be differentiated with plexiform neurofibroma or other plexiform malignant tumors. We describe a case of a 6-year-old patient with multiple cutaneous plexiform schwannomas who had no other stigmata of neurofibromatosis 1 or family history suggesting a genetic disorder. The histopathological study revealed a tumor composed of multiple intradermal or subcutaneous interlacing and interconnecting fascicles and nodules that vary in size and shape. Characteristic Antoni A type cellular tissue showing frequent nuclear palisading and Verocay bodies were observed within well circumscribed elongated nodules.
Child ; Christianity ; Dermis ; Humans ; Neurilemmoma* ; Neurofibroma, Plexiform ; Neurofibromatosis 1 ; Peripheral Nerves ; Subcutaneous Tissue

The nevus sebaceus of Jadsssohn is an organoid nevus generally noted on the scalp or the face as a single lesion. A 26-year-old man has suffered from a pea sized, pedunculated cherry red colored papule on the back ground of yellowish colored verrucous plaque on the vertex. Clinically, pedunculated papule was similar to granuloma pyogenicum, but histopathologic examination showed the features of tubular apocrine adenoma with focal areas of syringocystadenoma papilliferum, suggesting that might be a variant or could be associated with syringocystadenoma papilliferum.
Adenoma* ; Adult ; Granuloma, Pyogenic ; Humans ; Nevus* ; Nevus, Sebaceous of Jadassohn ; Organoids ; Peas ; Prunus persica ; Scalp

Psoriasis and eczematous dermatitis are two major different inflarnmtory dermatitis but differential diagnosis is sometimes difficult by histologic patterns. The object of this study is to find out whether there are any differences in the expressions of proliferation related pntein between psoriasis and eczematous dermatitis by chronological evaluation on the proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGFR). The detections of PCNA and EGFR were done by immunohistoc.ienical methods(alkaline phosphatase anti-alkaline phosphatase method with new fuchsin substrated usir g respective polyclonal antibod ies in the paraffin embedded tissue from psoriasis(21 cases) and eczomtous dermatitis(26 cases). The labelling indeces of PCNA were 2.4+0.9% in normal. Indece; were 27.3+2.9% in acute, 20.7+ 3.7% in chronic psoriasis, while 12.4+5.6% in acute and 21.8% 5.0% in chronic eczematous dermtitis. The expressions of EGFR were very weak in normal, and increased in acute psoriasis and chronic eczematous dermatitiy. Our immunohistochemical results of PCNA and EGFR suggest that activated proliferation is rather pronounced in acute psoriasis and chronic eczemat.ous dermatitis, thouh proliferative activity is more marked in psoriasis.
Dermatitis ; Diagnosis, Differential ; Eczema* ; Epidermal Growth Factor* ; Paraffin ; Proliferating Cell Nuclear Antigen* ; Psoriasis ; Receptor, Epidermal Growth Factor* ; Rosaniline Dyes