1.A case of advanced-stage endometrial stromal sarcoma of the ovary arising from endometriosis.
Ju A BACK ; Myeong Gyune CHOI ; U Chul JU ; Woo Dae KANG ; Seok Mo KIM
Obstetrics & Gynecology Science 2016;59(4):323-327
Endometrial stromal sarcoma (ESS) is a rare malignancy. Development of extrauterine ESS form endometriosis is particularly rare. The majority of extrauterine ESS occurs in areas with preexisting endometriosis. The most common site is the ovary. We experienced a case of ESS of the ovary that arose from endometriosis with multiple disseminated lesions. This disease was managed by total abdominal hysterectomy, bilateral salpingo-oophorectomy, both pelvic lymph nodes dissection, omentectomy, and appendectomy followed by postoperative high-dose progesterone therapy. Here, we report this case with literature review.
Appendectomy
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Endometriosis*
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Female
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Hysterectomy
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Lymph Nodes
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Ovary*
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Progesterone
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Sarcoma, Endometrial Stromal*
2.Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease.
Young Seok KIM ; Eun Sun JUNG ; Wonhee HUR ; Si Hyun BAE ; Jong Young CHOI ; Myeong Jun SONG ; Chang Wook KIM ; Se Hyun JO ; Chang Don LEE ; Young Sok LEE ; Sang Wook CHOI ; Jin Mo YANG ; Jeong Won JANG ; Sang Gyune KIM ; Seung Won JUNG ; Hee Kyung KIM ; Hee Bok CHAE ; Seung Kew YOON
Clinical and Molecular Hepatology 2013;19(2):120-130
BACKGROUND/AIMS: The aims of this study were (1) to identify the useful clinical parameters of noninvasive approach for distinguishing nonalcoholic steatohepatitis (NASH) from nonalcoholic fatty liver disease (NAFLD), and (2) to determine whether the levels of the identified parameters are correlated with the severity of liver injury in patients with NASH. METHODS: One hundred and eight consecutive patients with biopsy-proven NAFLD (age, 39.8+/-13.5 years, mean+/-SD; males, 67.6%) were prospectively enrolled from 10 participating centers across Korea. RESULTS: According to the original criteria for NAFLD subtypes, 67 patients (62.0%) had NASH (defined as steatosis with hepatocellular ballooning and/or Mallory-Denk bodies or fibrosis > or =2). Among those with NAFLD subtype 3 or 4, none had an NAFLD histologic activity score (NAS) below 3 points, 40.3% had a score of 3 or 4 points, and 59.7% had a score >4 points. Fragmented cytokeratin-18 (CK-18) levels were positively correlated with NAS (r=0.401), as well as NAS components such as lobular inflammation (r=0.387) and ballooning (r=0.231). Fragmented CK-18 was also correlated with aspartate aminotransferase (r=0.609), alanine aminotransferase (r=0.588), serum ferritin (r=0.432), and the fibrosis stage (r=0.314). A fragmented CK-18 cutoff level of 235.5 U/L yielded sensitivity, specificity, and positive and negative predictive values of 69.0%, 64.9%, 75.5% (95% CI 62.4-85.1), and 57.1% (95% CI 42.2-70.9), respectively, for the diagnosis of NASH. CONCLUSIONS: Serum fragmented CK-18 levels can be used to distinguish between NASH and NAFL. Further evaluation is required to determine whether the combined measurement of serum CK-18 and ferritin levels improves the diagnostic performance of this distinction.
Adult
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Aged
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Aged, 80 and over
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Alanine Transaminase/blood
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Asian Continental Ancestry Group
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Aspartate Aminotransferases/blood
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Biological Markers/blood
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Fatty Liver/classification/metabolism/*pathology
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Female
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Ferritins/blood
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Fibrosis/complications
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Humans
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Keratin-18/analysis
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Male
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Middle Aged
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Predictive Value of Tests
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Prospective Studies
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Republic of Korea
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Severity of Illness Index
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Young Adult