1.Structural-Functional Relationships in Renal Amyloidosis.
Myeong Cherl KOOK ; Hyun Soon LEE
Korean Journal of Pathology 1997;31(11):1190-1199
The pathogenetic mechanism of renal dysfunction in renal amyloidosis is poorly understood. To evaluate the morphologic parameters which are correlated with renal function in this disorder, we have examined renal biopsies from 14 patients with renal amyloidosis by morphometry. Of the 14 patients, 8 were male and 6 were female. They were between 41 and 70 years of age. The serum concentration of albumin and creatinine were 2.1+/-0.7 mg/dl and 1.1+/-0.5 mg/dl, respectively. The 24-hour excretion of urinary protein was 7.9+/-5.2 g. Creatinine clearance was 62+/-23 ml/min/1.73m2. The mean glomerular volume (MGV) was (2.2+/-1.3) 10(6) micrometer3. The surface density of peripheral glomerular basement membrane [Sv (PGBM/glom)] was 0.049+/-0.027 (micrometer3/micrometer3). Volume density of mesangium [Vv (mes/glom)] was 0.31+/-0.14 (micrometer3/micrometer3) and volume density of glomerular amyloid deposition [Vv (amyl/glom)] was 0.21+/-0.14 (micrometer3/micrometer3). The volume density of cortical interstitium [Vv (int/cortex)] was 0.14+/-0.09 (micrometer3/micrometer3). The serum creatinine concentration was significantly correlated with Vv (int/cortex) (r=+0.66, p<0.05). MGV was correlated with Vv (mes/glom) (r=+0.75, p<0.01) and Vv (amyl/glom) (r= +0.68, p<0.05) but showed negative correlation with Sv (PGBM/glom) (r=-0.79, p<0.01). Sv (PGBM/glom) showed negative correlation with Vv (mes/glom) (r=-0.77, p<0.01) and with Vv (amyl/glom) (r=-0.87, p<0.01). Positive correlation was observed between Vv (mes/glom) and Vv (amyl/glom) (r=+0.95, p<0.01). These results suggest that the decreased renal function in patients with amyloidosis is related to interstitial fibrosis rather than glomerular lesions. In addition, glomerular hypertrophy in these patients is related to amyloid deposition in the mesangium and peripheral glomerular basement membrane.
Amyloidosis*
;
Biopsy
;
Creatinine
;
Female
;
Fibrosis
;
Glomerular Basement Membrane
;
Humans
;
Hypertrophy
;
Male
;
Plaque, Amyloid
2.VATER Association: Three autopsy case reports with imusual defects.
Mi Ja LEE ; Myeong Cherl KOOK ; Je G CHI
Korean Journal of Pathology 1995;29(5):678-683
VATER association represents vertebral defects, anal atresia, tracheo-esophageal fistula with without esophageal atresia, renal defects and radial limb dysplasia. The probability of the simultaneous occurrence of any three of these defects is so unlikely that it suggests a sporadic non-random association. This non-random association appears to be related to some chromosomal anomalies, the caudal regression syndrome, mesodermal defects in early developmental period or the matemal use of sex hormones during embryogenesis. We report three autopsy cases of the VATER association that showed most of the known major and minor defects as well as an unusual concurrence of other defects, i.e., scoliosis, talipes varus, absent penis, urethral agenesis and stenosis, rectourethral fistula, rib anomaly, single umbilical artery, Meckel's diverticulum, diaphragmatic hemia, absent rectum, short neck, simian crease, low set ear, and hypoplastic lung.
3.Disputed parentage testing using pV47-2 multilocus probe.
Kyoung LEE ; Jae An JUNG ; Hyeon Koon MYEONG ; Juck Joon HWANG
Korean Journal of Legal Medicine 1993;17(1):24-34
No abstract available.
4.Comparison of capture rate for endocervical ekements of three papsmear methods.
Eal Whan PARK ; Myeong Chun LEE ; Bong Yul HUH
Journal of the Korean Academy of Family Medicine 1992;13(6):534-541
No abstract available.
5.The clinical analysis of biliary pancreatitis.
Jong Myeong LEE ; Bong Oak YOO ; Eul Sam CHUNG
Journal of the Korean Surgical Society 1991;40(3):321-332
No abstract available.
Pancreatitis*
6.Clinical and statistic analysis of cesarean section.
Ha Bong KIM ; Jong Seok KO ; Myeong Suk LEE
Korean Journal of Obstetrics and Gynecology 1993;36(7):1196-1205
No abstract available.
Cesarean Section*
;
Female
;
Pregnancy
8.Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection.
Myeong Heon SHIN ; Young Ah LEE ; Duk Young MIN
The Korean Journal of Parasitology 2009;47(Suppl):S125-S131
Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.
Animals
;
Eosinophils/*immunology/parasitology
;
Helminthiasis/*immunology/*parasitology
;
Helminths/*immunology
;
Host-Parasite Interactions
;
Humans
9.Two cases of ovarian pregnancy.
Ji Soo KIM ; Hyun Ae OH ; Myeong Hee LEE ; Kang Woo PHEE ; Soo Ja KIM ; In Myeong JOO ; Keun Min PARK
Korean Journal of Obstetrics and Gynecology 1993;36(7):2107-2116
No abstract available.
Female
;
Pregnancy
;
Pregnancy, Ectopic*
10.A case of Ovarian Metastasis from Carcinoma of the Gallbladder: a rare Krukenberg Tumor.
Seong Wook CHUNG ; Joo Myeong LEE ; Kei Hyun LEE ; Sang Dae KANG ; Suk Hee LEE
Korean Journal of Obstetrics and Gynecology 2000;43(4):755-758
A wide variety of cancers metastasize to the ovaries. In a majority of instances the primary site is the gastrointestinal tract, breast, or other gynecologic organs. The best known tumor of this type is signet-ring cell adenocarcinoma. The gallbladder and bile duct are rare sources of these metastases. The authors have had an experience of a case that was presented of Krukenberg tumor metastatic from the gallbladder and report the case with brief review of literature.
Adenocarcinoma
;
Bile Ducts
;
Breast
;
Female
;
Gallbladder*
;
Gastrointestinal Tract
;
Krukenberg Tumor*
;
Neoplasm Metastasis*
;
Ovary