Acquired Immunodeficiency Syndrome ; microbiology ; Female ; Humans ; Mycoses ; diagnosis ; Young Adult

Adult ; Diagnostic Errors ; Female ; Humans ; Laryngitis ; diagnosis ; microbiology ; Male ; Middle Aged ; Mycoses ; diagnosis ; Pharyngitis ; diagnosis ; microbiology

Adult ; Granuloma, Respiratory Tract ; microbiology ; Humans ; Male ; Mycoses ; diagnosis ; therapy ; Pharyngeal Diseases ; diagnosis ; microbiology ; therapy

Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; diagnosis ; microbiology ; prevention & control ; Mycoses ; diagnosis ; prevention & control

OBJECTIVE: The study was to evaluate the quality of life in patients with fungal rhino-sinusitis(FRS) and to investigate the relationship between different subjective tests.objective measures and that between subjective tests and objective measures. METHOD: Quantitative data of 18 preoperative recruits with FRS were collected by using sino-nasal outcome test-20 (SNOT-20) and then the SNOT-20 items were categorized into five domains, a visual analogue scale (VAS). Lund-Kennedy endoscopy staging system and the Lund-Mackay CT staging system. Correlation among these data was analyzed. RESULT: The six highest score items in SNOT-20 were Facial pain/pressure, Thick nasal discharge, Need to blow nose, Sneezing, Fatigue, and Frustrated/restless/irritable. The total SNOT-20 score was not correlated with the other objective or subjective tests(P > 0.05). However, there was significant correlation between SNOT-20 nasal symptom domain and Lund-Mackay T score( r = 0.605, P < 0.01), as well as between SNOT-20 sleep related symptom domain and VAS (r = 0.605, P = 0.008). Significant correlation was found between the Lund-Mackay CT staging and the VAS (r = 0.6150, P < 0.01), as well as between the Lund-Mackay CT staging and the Lund-Kennedy endoscopy staging (r = 0.5001 P < 0.05). There was no significant correlation between Lund Kennedy endoscopy staging and the patient-based questionnaires (P > 0.05). CONCLUSION The objective measures were correlated well with each other and CT staging had significant correlation with the SNOT-20 nasal symptom domain and VAS. There was also significant correlation between SNOT-20 sleep related symptom domain and VAS.
Female ; Humans ; Male ; Middle Aged ; Mycoses ; diagnosis ; Quality of Life ; Sinusitis ; diagnosis ; microbiology ; Surveys and Questionnaires

A 70 years old male patient complained a sense of swelling on right facial, mild pain, and the obstruction of right nasal, no complain of facial numbness and toothache. Physical examination showed the slight bulging on right facial with mild tenderness, purulent nasal secretions on the right middle nasal meatus, and no significant neoplasm. CT scan showed that soft density tissue in the right maxillary sinus,and the high density tissue in some period. Postoperative diagnosis: carcinoma of maxillary sinus with fungal sinusitis.
Aged ; Carcinoma ; complications ; diagnosis ; Humans ; Male ; Maxillary Sinus ; microbiology ; pathology ; Mycoses ; complications ; Nose Neoplasms ; complications ; diagnosis ; Sinusitis ; microbiology

Antifungal Agents ; therapeutic use ; Humans ; Male ; Mycoses ; diagnosis ; drug therapy ; Near Drowning ; microbiology ; Scedosporium ; pathogenicity

A young female complained repeated nasal discharge for over three months with discomfort of right cheek, and oral antibiotics had less effect. She has a history of "root canal therapy" five years before. Physical examination found purulent secretion in the right middle nasal meatus, and light tenderness in the right side of the maxillary sinus area. The CT scan of paranasal sinus shown possible fungal infection of right maxillary sinus. Finally the nasal endoscopic surgery confirmed the fungus ball of right maxillary sinus with foreign body (the root canal filling material).
Endoscopy ; Female ; Foreign Bodies ; diagnosis ; Humans ; Maxillary Sinus ; microbiology ; Maxillary Sinusitis ; microbiology ; Mycoses ; diagnosis ; Respiratory Tract Infections ; microbiology ; Tomography, X-Ray Computed

OBJECTIVE: To investigate the presentation and the management of allergic fungal rhinosinusitis (AFRS). METHOD: One case of AFRS was reported and the relevant literatures were reviewed. CT scan showed high-attenuation like "cloud and mist", Charcot-Leyden crystals and fungal hyphae were found in nasal smear. RESULT: The patient removed after a combined therapy of endoscopic sinus surgery, steroids and local antifungal drugs. CONCLUSION The diagnosis of AFRS depends on history, the characteristics of CT scanning, pathology, mycologic and immunologic test. The management of surgery, systemic immunotherapy, local antifungal drugs and longer follow up is very important.
Fungi ; isolation & purification ; pathogenicity ; Humans ; Male ; Mycoses ; diagnosis ; therapy ; Rhinitis, Allergic, Perennial ; diagnosis ; microbiology ; therapy ; Young Adult

OBJECTIVE: To investigate the clinical and pathological manifestation, prognosis of unilateral allergic fungal sinusitis (AFS), and to analyze the characters and treatment paradigm of unilateral AFS. METHOD: Clinical and pathological information of 10 cases of unilateral AFS were analyzed. Nasal endoscopy, skin prick test, and visual analogue score (VAS) of severity of illness were taken before surgery. Mucosa membrane and inspissated secretion obtained during endoscopic surgery were stained with hematoxylin-eosin and silver hexosamine. Regular clean of sinus and intranasal steroid spray were taken after surgery. RESULT: Endoscopy showed that 5 cases had pale mucous membranes in the ipsilateral nasal cavity. Skin prick test was positive in all patients. Nasal CT scan demonstrated unilateral lesion in all 10 patients. In the involved sinus, all 10 patients had brown or yellow brown viscous secretion, which demonstrated eosinophilic amorphous mass with accumulation of eosinophils, Charcot-Leyden crystallization and fungal hyphae under microscope. The number of eosinophils in lamina propria of sinus mucosa membrane was 72 +/- 11/hpf. After follow-up for 16 to 26 months(mean 22 months), 9 cases were cured and 1 improved. The pre-operative VAS was 8.5 +/- 1.2, and the post-operative VAS was 1.1 +/- 1.0 (P < 0.01). CONCLUSION The systemic and local allergic reaction may co-exist in unilateral AFS, in which local hypersensitivity may be the dominant reaction. Endoscopic sinus surgery and intranasal steroid spray are effective in the treatment of unilateral AFS.
Adult ; Female ; Humans ; Male ; Middle Aged ; Mycoses ; diagnosis ; therapy ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; diagnosis ; microbiology ; therapy ; Sinusitis ; diagnosis ; microbiology ; therapy