Objective：To study the mental health status of heroin addicts and their need for psychotherapy after detoxification. Methods：The mental health of 83 heroin addicts and 70 normal subjects were assessed by SCL-90, Social Support Rating Scale , EPQ, SAS and SDS. Results：As compared to normal controls, heroin additions were found to score higher on various mental health measures, including SCL-90 total and factor scores, the N score of EPQ, as well as total scores on SAS and SDS. The social support in heroin addicts scored lower than normal subjects. Conclusion：Heroin addicts have severe psychological problems, which warrant long-term psychological rehabilitation after detoxification.

Acute necrotizing encephalopathy（ANE）causes a very high mortality rate in children.However，the pathogenesis of ANE is still unclear，so no better treatment is available.Recent studies have shown that cytokine storms，genetic susceptibility，and mitochondrial dysfunction are key factors in the pathogenesis of ANE.It is now acknowledged that cytokine storms mediated by interleukin-6 and tumor necrosis factor-α are key factors in the pathogenesis of ANE in children.Genetic susceptibility due to genetic mutations plays an indirect role，and children with genetic mutations are more likely to develop ANE after exposure to influenza viruses.Mitochondrial dysfunction interacts with cytokines and gene mutations to jointly promote the development of ANE，but the exact mechanisms are unknown.We hope a deeper understanding of the pathogenesis of ANE will be achieved in the future.Therefore，the therapeutic regimens for ANE will be developed to limit the disease progression and to reduce the rate of disability and mortality in children.