Mistakenly picking and eating poisonous mushrooms can cause acute poisoning. In August 2020, Qingdao Hospital of Traditional Chinese Medicine handled a poisonous mushroom poisoning incident, conducted epidemiological investigation on all poisoned patients, collected suspicious food, clinical manifestations, clinical test results and treatment conditions, and identified the mushrooms as Amanita fuliginea poisoning after morphological identification. In this incident, 6 people ate grey goose paste, of which 4 were sick with a incubation period of 6~12 h. The clinical manifestations were gastrointestinal symptoms such as nausea, vomiting and diarrhea, liver and kidney damage. After symptomatic support treatment, hemoperfusion or continuous hemofiltration treatment, the patients were cured and discharged. It is suggested to strengthen the popular science education on poisonous mushroom poisoning and improve the ability of identification and clinical treatment of poisonous mushrooms in grass-roots medical institutions.
Amanita ; Hemoperfusion ; Humans ; Liver ; Mushroom Poisoning/therapy*

Humans ; Liver Diseases ; etiology ; therapy ; Male ; Middle Aged ; Mushroom Poisoning ; therapy ; Plasmapheresis

Adult ; Aged ; Child ; Child, Preschool ; Female ; Gastric Lavage ; Humans ; Male ; Middle Aged ; Mushroom Poisoning ; therapy

Adult ; Child ; Early Diagnosis ; Female ; Humans ; Male ; Mushroom Poisoning ; diagnosis ; therapy

Mushroom poisonings are potentially fatal. Most fatalities are due to the amatoxin that causes fulminant hepatic failure and acute renal failure. We report a patient who developed acute renal failure after ingesting Amanita virgineoides, which required renal replacement therapy, despite recovery of liver injury. A kidney biopsy showed acute tubular necrosis. The patient was recovered with the supportive care and temporary hemodialysis.
Acute Kidney Injury ; Amanita ; Amanitins ; Biopsy ; Humans ; Kidney ; Liver ; Liver Failure, Acute ; Mushroom Poisoning ; Necrosis ; Renal Dialysis ; Renal Replacement Therapy

Adolescent ; Adult ; Amanita ; Chemical and Drug Induced Liver Injury ; etiology ; therapy ; Female ; Humans ; Male ; Middle Aged ; Mushroom Poisoning ; therapy ; Retrospective Studies ; Young Adult

Adolescent ; Adult ; Amanita ; Amanitins ; blood ; Child ; Child, Preschool ; Female ; Hemoperfusion ; Humans ; Liver Diseases ; etiology ; therapy ; Liver, Artificial ; Male ; Mushroom Poisoning ; complications ; therapy ; Plasma Exchange ; Sorption Detoxification

Podostroma cornu-damae is a rare species of fungus belonging to the Hyocreaceae family. Its fruit body is highly toxic, as it contains trichothecene mycotoxins. Unfortunately, it highly resembles Ganoderma lucidum and Cordyceps, well-known health foods; this can lead to poisoning. We experienced such a case of a 42-year old man who received mushroom poisoning by injesting Podostroma cornu-damae. The patient was presented with severe pancytopenia and infection. The patient recovered without any complications after conservative care, antibiotics therapy, and granulocyte colony stimulating factor administration. The most common complications of podostroma cornu-damae intoxication were reported pancytopenia, infection, disseminated intravascular coagulation, acute renal failure, etc. It is important to provide enough fluid therapy, use of antibiotics to infection and granulocyte colony stimulating factor administration.
Acute Kidney Injury ; Agaricales ; Anti-Bacterial Agents ; Colony-Stimulating Factors ; Cordyceps ; Disseminated Intravascular Coagulation ; Fluid Therapy ; Fruit ; Fungi ; Granulocytes ; Humans ; Mushroom Poisoning ; Mycotoxins ; Pancytopenia ; Reishi ; Trichothecenes

OBJECTIVETo observe the curative effects of transmetil on Amanita verna poisoning.

METHODSTwelve cases with Amanita verna poisoning were reviewed. The patients were divided into 2 groups according to usage of transmetil: Group A was treated with traditional protocol (gastric lavage, catharsis, rehydration, diuresis, anti-infection and hemodialysis), Group B was treated with traditional protocol combined with transmetil. The liver function changes on the 1st, 3rd, 5th and 7th day after poisoning and the mortality were compared between 2 groups.

RESULTSTwo cases in group A (6 patients) died. The mortality of group A was 33.3%. The AST levels continued to increase on the 3rd and 5th day, but decreased on the 7th day. TBIL continued to increased on the 1st, 3rd, 5th and 7th day. None in group B died. The TBIL level dropped at 7 d 5 patients showed an increase in ALT at 7 d and 3 patients showed a decrease in AST at 7 d.

CONCLUSIONTransmetil may play an important role in reducing the mortality of Amanita verna poisoning.

Adolescent ; Adult ; Aged, 80 and over ; Amanita ; Female ; Humans ; Male ; Middle Aged ; Mushroom Poisoning ; drug therapy ; Retrospective Studies ; S-Adenosylmethionine ; therapeutic use

OBJECTIVETo observe the effect of Ganoderma lucidum decoction in treating Russula subnigricans poisoning (RSP) patients.

METHODSThe 14 patients of RSP in the treated group were treated with GLD (GLD, one dose was prepared by 100 g of Ganoderma lucidum decocted with water to 600 ml), on the base of conventional treatment, and 11 patients received conventional therapy in the previous year were taken as control. The clinical efficacy and parameters in them were compared, including the urine N-acetyl-D-glucosaminidase (NAG, which reflects the injury of kidney), the red blood cell and protein in urine, the alanine transaminase (ALT, which reflects the injury of liver), and the aspartate aminotransferase (AST, which reflects the injury of heart).

RESULTSA better clinical cure-markedly improving rate was showed in the treated group as compared with the control group, P < 0.01. In the treated group, red blood cell in urine disappeared after 24 hrs treatment in the majority of patients, urinary protein reduced obviously and the other three parameters reached the peak at the 3rd day then lowered gradually. In the control group, all the parameters increased continuously. Comparison between the parameters at corresponding time in the two groups showed significant difference (P < 0.01), those in the treated group were markedly lower than those in the control group respectively.

CONCLUSIONGLD has good effect in treating RSP, could obviously lower the fatat rate of RSP.

Acetylglucosaminidase ; urine ; Adolescent ; Adult ; Aged ; Alanine Transaminase ; blood ; Aspartate Aminotransferases ; blood ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Middle Aged ; Mushroom Poisoning ; drug therapy ; Phytotherapy ; Reishi ; chemistry