1.Bone Metabolism and Bone Mineral Density in Premenopausal Women with Mild Depression.
Vural KAVUNCU ; Murat KULOGLU ; Arzu KAYA ; Sezai SAHIN ; Murad ATMACA ; Burak FIRIDIN
Yonsei Medical Journal 2002;43(1):101-108
This study was undertaken to investigate the bone metabolism and bone mineral density (BMD) in female patients suffering from depression. Forty-two female patients diagnosed with depression and 42 healthy women, all in the premenopausal age, were enrolled. A clinical evaluation, measurements of the biochemical markers of bone metabolism and BMD measurements were performed. The BMD values were found to be similar in all measured sites. It was concluded that a low BMD was not a prominent feature of premenopausal women with mild depression, even though an increase in bone resorption was found.
Adult
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Antidepressive Agents/adverse effects
;
*Bone Density
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Bone and Bones/*metabolism
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Depression/drug therapy/*metabolism
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Female
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Human
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Middle Age
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Premenopause
2.Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities.
Cengiz DEMIR ; Mustafa Kasim KARAHOCAGIL ; Ramazan ESEN ; Murat ATMACA ; Hayriye GÖNÜLLÜ ; Hayrettin AKDENIZ
Chinese Medical Journal 2012;125(11):1871-1876
BACKGROUNDBrucellosis can mimic various multisytem diseases, showing wide clinical polymorphism that frequently leads to misdiagnosis and treatment delay, further increasing the complication rates. In this study, we aimed to examine bone marrow biopsy findings in brucellosis cases presenting with hematologic abnormalities.
METHODSForty-eight brucellosis cases were prospectively investigated. Complaints and physical examination findings of patients were recorded. Patients' complete blood count, routine biochemical tests, erythrocyte sedimentation rate, C-reactive protein and serological screenings were performed. Bone marrow biopsy and aspiration was performed in patients with cytopenia, for bone marrow examination and brucella culture, in accordance with the standard procedures from spina iliaca posterior superior region of pelvic bone.
RESULTSOf the 48 patients, 35 (73%) were female and 13 (27%) were male. Mean age was (34.8 ± 15.4) years (age range: 15 - 70 years). Anemia, leukopenia, thrombocytopenia and pancytopenia were found in 39 (81%), 28 (58%), 22 (46%) and 10 patients (21%), respectively. In the examination of bone marrow, hypercellularity was found in 35 (73%) patients. Increased megacariocytic, erythroid and granulocytic series were found in 28 (58%), 15 (31%) and 5 (10%) patients, respectively. In addition, hemophagocytosis was observed in 15 (31%) patients, granuloma observed in 12 (25%) and increased eosinophil and plasma cells observed in 9 (19%) patients.
CONCLUSIONAccording to the results of our series, hemophagocytosis, microgranuloma formation and hypersplenism may be responsible for hematologic complications of brucellosis.
Adolescent ; Adult ; Aged ; Biopsy ; methods ; Bone Marrow ; metabolism ; pathology ; Brucellosis ; complications ; metabolism ; physiopathology ; C-Reactive Protein ; metabolism ; Female ; Granuloma ; etiology ; metabolism ; physiopathology ; Humans ; Hypersplenism ; etiology ; metabolism ; physiopathology ; Male ; Middle Aged ; Prospective Studies ; Young Adult