AbstractIntroduction: Effects of medicine have many influential pharmaceutical and non-pharmaceutical factors. Term, “factors of medicine had been out because clinical research had proven that effect of medicine and reaction depends on medicine preparation technology, type of medicine, method to apply medicine. Prior to that, it was considered that quality of medicine depends on physical and chemistry conditions of medical ingredients, amount of active ingredients, etc. Bio digestion of medicine is an important criteria to take correct treatment, to reduce side effects in order to providing medical safety, to improve medicine quality, and to increase treatment impact. This study is about to prove that medical effect depends on medical factor particularly type of medicinePurpose: Aim is to study drug medical dissimilarity action in vivo enviromentMaterials and Methods: diuretics pharmacology tests 18-24gr 40 pieces weighting Balb /cshugamyn conducted on mice. Test "Monos" pharmacological sector in cooperation with the Institute for Research on drugs. Statistics by SPSS-20 software implementation and results of student criteria (p<0.05) was recognized and confirmed by one way ANOVA.Research is completedthe diuretics in the following the next sequence (Tryeindlinburg, 1980) 1. The research was conducted prior to the start of the test animals 0,3ml / 20gr doses of saline solution (NaCl 0.9%) treated with oral fluid pressure generated2. The research groups of injecting drug predicted doses experimental animals to drink5.3. Drinking the drug preparations 2.5 hours after the 30-minute intervals during the test animals urine test groups amount of urine of animals (p <0.05) compares.Result: Experimental animals, urine collected during the 30-minute interval of 2.5 hours, urine volume between the groups was compared with the control group.Administered medications, a comparative study of the Russian Federation " X1" acting industry furosemid make urinate "X2" Company "X3" LLC furosemid (p <0.05) compared to the control groups entails strong drugs furosemide make urinate consistent.Table form of furosemide drugs that acts comparative study of the Russian Federation "X1" acting industry furosemide make urinate "X4" Pharm Co Ltd furosemide (p <0.05) entails experimental groups with the control group furosemide make urinate strong comparison function (p <0.05)Conclusion:Medical activity that was different shows drug medical dissimilarity action, when comparing between types of pyroselid drug in various industries.Key words: Tablet form, active treatment, furosemide, injection, tablet, drug therapy acts as