Urogenital mycoplasmosis is infectious inflammatory disease of the urinary tract caused by Mycoplasma exclusively. Pathogens of mycoplasma and ureaplasma are related to their biological rare uniqueness. Mycoplasma and ureaplasma has very small size of genome and lack a rigid cell wall. They are able to enter host cell membrane and multiply in it. This protects them from cellular and humoral immune reaction. This unique feature is the reason why the infection is often mysterious and asymptomatic. The dangerous difficulty of the ureaplasma and mycoplasma infection of the urinary tract leads to infertility, chronic endometritis, pregnancy without growing, fetal anomalies, primary and secondary placental shortage. Therefore, it is necessary to determine diagnostic approach and to study the extent the influence eproduction and the prevalence of causative agent.We analyzed the objects which derived from women with the pathogen for the period beginning from January 2014 up until January 2015 collaborating with “Oncogenic” laboratory at the National Center for Research on Cancer based on the women clinic “UilsButemj”. Total of 43 women who diagnosed to have key cells by vaginal smear test were included in the PCR analysis. Total of 12 healthy women who does not have obstetric chronic anamnesis were selected to be included in the analysis by creating control group. The study was done by the prospective case study model. IBM SPSS 20.0 software was used to process the results of the study. 43 women who were involved in the analysis were chosen by the following criteria: 1.With genitourinary complaints, 2.With positive key cells of the vaginal smear test.The average life expectancy of the women surveyed was 31,4±5,6. (min 22, max 53). The majority or 92.7% obtained high education and 7.3% have secondary education. For marital status, 74.5% have their own families and 25.5% of the total women involved were single. There were 15 infertile women or 34.8%, 11 miscarriage women or 25.5% and 12 women with pregnancy without growing or 27.9%, 4 women diagnosed to be pregnant outside of the uterus or 9.3%. The infection combined with U parvum and M hominis which cause pathogen accounted for 40% among total infertile women. The more combined the infection the more virulent. The following originators were detected by the PCR analysis which was run among the total of 43 women with pathogen:U.parvum 32 women, or 74.4%, U.urealiticum 11, or 25.5%, M.hominis 24, or 55.8%, M. Genitalis 4, or 9.3%, Gardnerella 31, or 72.9%, were detected respectively in single or co-discovered way and the majority of them are U.parvum and Gardnerella originators. 10 women, or 83.3%, with U.parvum, 3 women, or 25% with U.urealiticum, 4 women, or 33.3% with M.hominis, 1 woman or 8.3% with M. Genitalis and 7 women, or 41.6% with Gardnerella were detected respectively by the PCR analysis which was done in healthy women without any obstetiic chronic memory. Therefore, types of ureaplasma and mycoplasma is infected to human body as situational pathogen creator and those situational pathogen creators lead to difficulty by creating pathogen in case they shifts to the pathogen creator form. The fact that there were 15 infertile women or 34.8%, 11 miscarried women or 25.5%, 12 pregnant women without growing or 27.9%, 4 pregnant women outside of vagina or 9.3% shows that these pathogen creators are the factor for further difficulty.