Background: The World Health Organization (WHO) estimates that the number of cancerrelated deaths will increase by 45 percent between 2008 and 2030. Following this estimate, many projects and programs have been implemented to improve cancer prevention, diagnosis, and treatment, but the number of new cancer cases and deaths is increasing worldwide. In 2018, 6073 new cancer cases were registered in Mongolia.² As of 2018, there are 19,427 cancer patients under the supervision of aimag and district oncologists. In our country, 78.8 percent of all cancers are diagnosed in stage 3.4 and are transferred to palliative care. However, in our country, there is a lack of research on the family, caregiver burden and quality of life of patients receiving palliative care. Therefore, we aimed to assess the caregivers of burden and quality of life of family of cancer patients in this study. Methods: The survey was conducted between November 2017 and December 2018 using an analytical instantaneous model. The survey data were collected from caregivers of cancer patients at the National Cancer Center, Ulaanbaatar District Health Center, Green Ger, and Iveel Hospice. Quality of life was assessed using the WHO WHOQOL-BREF method. The caregiver burden of cancer patients receiving palliative care was assessed using the Caregiver burden inventory international standard questionnaire. Results: The study involved 180 caregivers aged 20 to 72 years. 82.8 percent of the total guardians are women and 17.2 percent are men. The quality of life of the caregivers surveyed was 65.0 percent. In terms of the quality of life of caregivers, the environment is 59.9 percent, social relations 69.2 percent, psychological 70.8 percent, and physical 64.0 percent. The quality of life of caregivers was rated 69.8 percent for men and 64.0 percent for women, or relatively low for women. A statistically significant indicator is that the quality of life of caregivers decreases as patients spend more time per day (p = 0.013). The average workload score for caregivers is 32.97±11.8 for men and 40.53±14.9 for women, which is a statistically significant difference. The inverse relationship between caregiver quality of life and workload is a statistically significant indicator. / r = - 0.61 /. Conclusions The quality of life of caregivers participating in the study decreased. In addition, 91.7 percent have a caregiver burden level of 2 and more, which indicates that the caregivers of cancer patients are overworked. According to the results of the linear regression analysis, the quality of life decreases by 0.56 units when the caregiver’s workload increases by 1 unit.

Kidney transplantation is the best alternative treatment for end-stage renal disease and health-related quality of life and survival of the patients are improved compared with dialysis. Worldwide, more than 1.4 million patients with CKD receive renal replacement therapy with incidence growing by approximately 8% annually.1 Unfortunately, despite significant improvement in graft function, kidney transplants can still fail due to acute rejection and chronic allograft nephropathy.2 Kidney biopsy after transplantation, which has evaluated by Banff 09 classification is usefull method for diagnose of transplanted kidney disease.3,4Kidney graft rejection was diagnosed in 10 renal allograft biopsy specimens (bs) obtained from transplant patients followed up at our institute between 2015 and 2016. All specimens were evaluated as satisfactory which show more than 8 glomerulus under the light microscopy. Each renal cortical tissue was divided into two tips: one piece for routine H&E stain and special stains, including Masson’s trichrome, and PAS stain; another piece for immunofluorescence by frozen section, which were stained with IgA, IgM, IgG and complement component (C3, C4, C1q, C4d). All the renal biopsies were examined by the same pathologist.Out of 117 transplantations, 10 episodes of rejection selected. Among the 10 patients, 30% had an acute T cell rejection and 70% had a chronic allograft nephropathy. Interstitial inflammation (i1-7) was present in 7 bs (70%), tubulitis (t1-4,t2-2) in 6 bs (60%), transplant glomerulitis (g1-1, g2-2, g3-1) in 4 bs (40%), transplant interstitial fibrosis (ci1-2, ci2-2, ci3-2) in 6 bs (60%), tubular atrophy (ct1-6, ct2-2, ct3-1) in 9 bs (90%), mesangial matrix increase (mm1-5) in 5 bs (50%), vascular fibrosis intimal thickeness (cv1-3) in 3 bs (30%), arteriolar hyaline thickening (ah1-5) in 5 bs (50%), tubulitis (ti1-6, ti2-3, ti3-1) in 10 bs (100%) and peritubular capillaritis (ptc1-1, ptc2-2, ptc3-1) in 4 bs (40%). C4d deposition was present very mild in wall of the vessels and peritubular capillaries. Because of not good working Methenamin silver stain, we couldn’t demostrate glomerular basement membrane changes (cg) fully.We suggest that histopathological changes of transplant glomerulopathy might be accompanied by inflammation of the microvasculature, such as transplant glomerulitis and peritubular capillaritis. C4d deposition in the wall of the vessels and peritubular capillaritis is not always present in biopsy specimens of transplant glomerulopathy.