Background: Most of the country has been increasing the life expectancy and to relate aging man also have been increasing among population. Affected by human aging internal major factor is the change of Hypothalamus-Pituitary-Gonadal axis. Thus, we have proposed to study to change of regulating gonadothropin-gonadal axe in aging males. Goal: To study the serum total testosterone, gonadothropin hormones level in aging males and its correlation with aging. Materials and Methods: In this study were involved 149 healthy Mongolian men aged above 35 years. Subjects were randomly selected. Blood samples were collected in the morning 8.30-10.00 AM, 4ml blood from vein vassal. The serum concentration of total testosterone, luteinizing hormone, follicle stimulating hormone was assayed by ELISA. Results: Total participant’s average age was 57.8±13.4 years. Average level of testosterone was 4.95±2.08ng/ml and there is no significant correlation with aging (r=0.084, p=0.331). But average level of FSH was 9.12±9.09 IU/L and FSH has increased with aging. Between age and FSH was found moderate and direct correlation (r=0.425, p<0.001). Average level of luteinizing hormone was 11.41±9.83 IU/L and LH had significant, direct correlation with age (r=0.216, p<0.05). Gonadothropins FSH and LH were analyzed by ANOVA in different age groups and have not identified significant difference between age groups. Which allows hypothesize that in gonadotropins secretion no rapid change in age different groups. Conclusions: 1. Average level of testosterone in participating men was 4.95±2.08ng/ml and there is no significant correlation with aging (r=0.084, p=0.331). 2. Average level of FSH was 9.12±9.09 IU/l, had age related significant correlation (r=0.425, p<0.001), average level of LH was 11.41±9.83 IU/l and had significant, direct correlation with age (r=0.216, p<0.05). Not found significant difference between age groups. 3. Multiple regression analyze showed insignificant (p>0.05) correlation of LH (β=0.170) with Testosterone, which was stronger than FSH (β=0.156).

Introduction: Among women with Polycystic Ovarian Syndrome (PCOS), obesity is one of the diagnosis criteria and it is evaluated by waist circumference. We aimed to determine the measurement of waist circumference in women with PCOS. Obesity and PCOS tend to increase throughout the world. In 1994, leptin was discovered to be directly related to body mass index in obesity. Ovarian cystic syndrome has been shown to be associated with leptin levels and also that indicating the need for prevention of obesity in women. Objective: Clinical and medical determination for the waist circumference of women with PCOS and comporation study to leptin and comparative study to leptin levels. Мaterial and Methods: This research included a total of 86 women aged 18-35 in Ulaanbaatar city. We took a permission to start the research at the meeting of the Research Ethics Council of the Mongolian National University of Medical Sciences on March 22, 2019. Statistical analysis of this study results was performed using SPSS 19.0, text recording using Microsoft Office 2018 software, T-test to exclude group differences, ANOVA test for differences between more than two groups, and p<0.05 statistical probability difference. Results: The research of the 56 women tested for leptin in the serum of women with PCOS, 28 (32.5%) had a normal BMI with PCOS and 28 (32.5%) had an excess of BMI with PCOS, respectively. The mean levels of leptin was 13.86±11.40 kg/ml for people with normal BMI, PCOS and 33.78±17.63 kg/ml for people with excess BMI, PCOS. Leptin is higher in women with BMI, PCOS and this result is statistically significant (P-value 0.000). Conclusion Leptin levels are higher during PCOS, and leptin levels increase as the number of risk factors increases. Leptin secretion is affected by BMI and waist circumference.