INTRODUCTION More attention is paid recently following the increase in vascular diseases which 1MH3jnr is affecting the disability rate of the population at working age. Arteriovenous - malformation can occur at any place of human body and cause different levels of complaints and disability. OBJECTIVE Main goal was to make complete diagnosis of the AVM of lower extremity and to identify necessary coil for the treatment after to analyze the treatment result after the procedure. METHOD The treatment procedure of Lower extremity AVM was accomplished on 29 year old female at Angiography department of Shastin's Central Hospital. AVM was created by the anastomosis made between a. glutca superior, a.glutca inferior, a.obturatoria dextra and v.glutca superior, v.glutea inferior, v.obturatoria dexstra which have created pulsatile, pain at m.gluteus major et minor level. In control picture after the M.Coli embolization treatment the filling of the malformation have disappeared expressing the successful result. CONCLUSION Having previous experience of M.Coli embolization of brain vessel malformation we need to improve the skill and perform the procedure for different caliber vessels of the brain. It is preferable that we perform embolization treatment prior to surgical treatment and analyze the result.

S100 proteins regulate intracellular processes such as cell growth and motility, cell cycle regulation, transcription and differentiation. S100 proteins represent the largest subgroup in the EF-hand Ca²⁺ binding protein family. The S100 protein family consists of 24 members functionally distributed into three main subgroups: those that only exert intracellular regulatory effects, those with intracellular and extracellular functions and those which mainly exert extracellular regulatory effects.
Within cells, S100 proteins are involved in aspects of regulation of proliferation, differentiation, apoptosis, Ca²⁺ homeostasis, energy metabolism, inflammation and migration/invasion through interactions with a variety of target proteins including enzymes, cytoskeletal subunits, receptors, transcription factors and nucleic acids. S100 proteins have received increasing attention due to their close association with several human diseases including cardiomyopathy, neurodegenerative disorders and cancer. They have also been proven to be valuable in the diagnostic of these diseases, as predictive markers of improving clinical management, outcome and survival of patients and are considered having a potential as drug targets to improve therapies.