1.Ovarian conservation for young women with clinical stage IB–IIB cervical cancer in Japan.
Koji MATSUO ; Muneaki SHIMADA ; Mikio MIKAMI
Journal of Gynecologic Oncology 2017;28(4):e60-
No abstract available.
Female
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Humans
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Japan*
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Uterine Cervical Neoplasms*
2.Prevalence of β₂-agonist inhalation for outpatients in a pediatric emergency center during enterovirus D68 epidemic
Masafumi ZAITSU ; Tatsuhiro MIZOGUCHI ; Muneaki MATSUO ; Toshimitsu TAKAYANAGI ; Okito SHIMADA ; Tsuneyoshi BABA
Asia Pacific Allergy 2018;8(2):e16-
BACKGROUND: Enterovirus D68 (EV-D68) has been reported to have caused severe bronchial asthma attacks and hospitalization epidemics in Japan in September 2015. OBJECTIVE: To investigate the prevalence of β2-agonist inhalation in a pediatric emergency center during a period of increased hospitalization for bronchial asthma, which was suggested to be associated with EV-D68. METHODS: We investigated the prevalence of β2-agonist inhalation in a pediatric emergency center in Saga city, Japan, from April 2013 to October 2015, and also clarified the trends in bronchial asthma hospitalization in the same area during that time. RESULTS: The prevalence of β2-agonist inhalation in the pediatric emergency center, September 2015 was highest when EV-D68 became widespread. The monthly average for β2-agonist inhalation during the study period was 91 cases, but the count in September 2015 was 255 cases. Hospitalized cases of bronchial asthma in September 2015 were increased for age ≥3 years and not increased for age <3 years, but the prevalence of β2-agonist inhalation at the pediatric emergency center was increased even under the age of 3 years. CONCLUSION: During the epidemic period for EV-D68, cases requiring β2-agonist inhalation were increased. The EV-D68 epidemic may be related to not only severe cases requiring hospitalization, but also exacerbation of relatively mild symptoms of bronchial asthma.
Asthma
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Emergencies
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Enterovirus
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Hospitalization
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Humans
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Inhalation
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Japan
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Outpatients
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Prevalence
3.Risk stratification models for para-aortic lymph node metastasis and recurrence in stage IB–IIB cervical cancer
Koji MATSUO ; Muneaki SHIMADA ; Tsuyoshi SAITO ; Kazuhiro TAKEHARA ; Hideki TOKUNAGA ; Yoh WATANABE ; Yukiharu TODO ; Ken ichirou MORISHIGE ; Mikio MIKAMI ; Toru SUGIYAMA
Journal of Gynecologic Oncology 2018;29(1):e11-
OBJECTIVE: To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo PAN dissection at radical hysterectomy. METHODS: This is a retrospective analysis of a nation-wide cohort study of surgically-treated stage IB–IIB cervical cancer (n=5,620). Multivariate models were used to identify independent surgical-pathological predictors for PAN metastasis/recurrence. RESULTS: There were 120 (2.1%) cases of PAN metastasis at surgery with parametrial involvement (adjusted odds ratio [aOR]=1.65), deep stromal invasion (aOR=2.61), ovarian metastasis (aOR=3.10), and pelvic nodal metastasis (single-node aOR=5.39 and multiple-node aOR=33.5, respectively) being independent risk factors (all, p<0.05). Without any risk factors, the incidence of PAN metastasis was 0.9%, while women exhibiting certain risk factor patterns (>20% of the study population) had PAN metastasis incidences of ≥4%. Among 4,663 clinically PAN-negative cases at surgery, PAN recurrence was seen in 195 (4.2%) cases that was significantly higher than histologically PAN-negative cases (2.5%, p=0.046). In clinically PAN-negative cases, parametrial involvement (adjusted hazard ratio [aHR]=1.67), lympho-vascular space invasion (aHR=1.95), ovarian metastasis (aHR=2.60), and pelvic lymph node metastasis (single-node aHR=2.49 and multiple-node aHR=8.11, respectively) were independently associated with increased risk of PAN recurrence (all, p<0.05). Without any risk factors, 5-year PAN recurrence risk was 0.8%; however, women demonstrating certain risk factor patterns (>15% of the clinically PAN-negative population) had 5-year PAN recurrence risks being ≥8%. CONCLUSION: Surgical-pathological risk factors proposed in this study will be useful to identify women with increased risk of PAN metastasis/recurrence.
Cohort Studies
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Female
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Humans
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Hysterectomy
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Incidence
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Lymph Nodes
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Neoplasm Metastasis
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Odds Ratio
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Recurrence
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Retrospective Studies
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Risk Factors
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Uterine Cervical Neoplasms