1.Assessment of Resistive Index in Acute Epididymitis on Doppler Sonography.
Moon Gyu LEE ; Yong Ho AUH ; Kyoung Sik CHO ; Hyo Kyeong CHOI ; Seung Mun JUNG ; Chung Soo KIM
Journal of the Korean Radiological Society 1995;32(6):947-951
PURPOSE: This study was aimed to review findings of gray-scale ultrasonography and to assess the diagnostic value of the resistive index (RI) in patients with acute epididymitis by comparing with that in normal volunteers. MATERIALS & METHODS: Gray-scale ultrasonogram was reviewed in nine patients with acute epididymitis for echogenicity, size and reactive hydrocele. Normal values of resistive index (RI) were obtained in 20 epididymides from 10 volunteers (aged 20-28, mean 23.7). Nine patients of epididymitis (aged 18-67, mean 37.2) were examinated with color Doppler sonography and RI was measured at 11 sites on epididymal arteries. For the prediction of acute epididymitis, accuracy, sensitivity and specificity were calculated at the cut-off value of RI in 0.65 and 0.70. RESULTS: Gray-scale ultrasonography showed echogenicity that was variable among the 9 cases (hype- rechoic 2 cases, isoechoic 2, hypoechoic 5), enlargement of epididymis in 8, and reactive hydrocele in 8 cases. Normal volunteers displayed color Doppler signals in 14 out of 20. The range of RI in normal volunteers were between 0.64 and 1.00 (mean, 0.79 +/- SD 0.10). In patients with acute epididymitis, color Doppler signals were detected in all patients. The range of RI in epididymitis were 0.40-0.68 (mean, 0.56 +/- SD 0.10). At cut-off RI value of 0.65, accuracy was 88%, sensitivity 81.8%, and specificity 92.7%. At cut-off value of 0.70, accuracy was 92%, sensitivity 100%, and specificity 85.7%. CONCLUSION: In addition to the findings of gray-scale ultrasonography, resistive index and color flow changes are valuable in diagnosing acute epididymitis.
Arteries
;
Epididymis
;
Epididymitis*
;
Healthy Volunteers
;
Humans
;
Male
;
Reference Values
;
Sensitivity and Specificity
;
Ultrasonography
;
Volunteers
2.Autoregulation of Quartz-induced iNOS by iNOS-derived Hydrogen Peroxide in Rat2 Fibroblast.
Kyoung Ah KIM ; Hae Yun NAM ; Je Hyeok MUN ; Jin Sook JEONG ; Young LIM ; Chee Kyung CHUNG
Korean Journal of Occupational and Environmental Medicine 2001;13(4):385-392
OBJECTIVES: This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase(NOS) induced by alpha-quartz in Rat2 fibroblast. METHODS: alpha-quartz-induced nitric oxide(NO) and H2O2 formation and alpha- quartz-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor(L-N6- (1-iminoethyl)lysine hydrochloride, L-NIL) or antioxidant(catalase), we observed NO and H2O2 formation and iNOS protein expression in Rat2 fibroblast stimulated with alpha-quartz. RESULTS: alpha-quartz stimulated iNOS-induced NO and H2O2 formation in Rat2 fibroblast. L-NIL inhibited H2O2 formation and iNOS protein expression by alpha-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOSinduced H2O2, therefore H2O2 and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with alpha-quartz CONCLUSIONS: alpha-quartz-induced iNOS stimulated H2O2 formation in Rat2 fibroblast. INOS-induced H2O2 by alpha-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast
Catalase
;
Fibroblasts*
;
Homeostasis*
;
Hydrogen Peroxide*
;
Hydrogen*
;
Nitric Oxide
;
Quartz
3.Usefulness of Echocardiography in the Evaluation of Paracardiac Masses.
Tae Weon KIM ; Kyoung Sig CHANG ; Gyoung Mu HER ; Chai Jung YOON ; Gwan Eung PARK ; Seung Mun CHUNG ; Soon Pyo HONG
Korean Circulation Journal 1996;26(4):803-812
BACKGROUND: Echocardiography gives a window to mediastinal or paracardiac structures. When mediastinal or paracardiac masses are detected by a routine chest X-ray and thoracic CT, the difference between vascular and nonvascular lesions may be difficult to diagnose. In these situations, echocardiography has been successfully used recently. CT can be easily standardized and allows visualization of the whole chest, but it is less precise in defining highly mobile structures, more expensive and difficult to perform in patients with orthopnea. But echocardiography is easy to perform, gives real time images. We performed this study to evaluate the usefulness of echocardiography in the identification and investigation of the structural and functional effects of paracardiac masses. METHODS: Twenty patients with paracardiac masses detected by chest X-ray and thoracic CT were examined by transthoracic and/or transesophageal echocardiography. We studied the characteristics of masses and compression site by 2-D echocardiographic techniques and also evaluation of functional effects of a paracardiac masses on heart and great vessels by color pulsed waved Doppler echocardiographic techniques. RESULTS: Nine patients(45.0%) had cystic masses, eleven patients(55.0%) had solid masses. All cystic masses revealed benign, and all solid masses revealed malignant. Among metastatic paracardiac tumors, the most frequent primary site were lung. heart chambers were compressed by paracardiac masses in five cases(26.7%) and great vessel compressed in thirteen cases(76.4%). Turbulent flow and peak velocity documented by color and PW dopple suggested that it is hemodynamically significant compression states of the great vessels by masses. CONCLUSIONS: We consider that echocardiography is as useful as other noninvasive radiographic techniques in the evaluation of paracardiac masses and their mechanical effect upon the function of the heart and great vessels.
Echocardiography*
;
Echocardiography, Doppler
;
Echocardiography, Transesophageal
;
Heart
;
Humans
;
Lung
;
Thorax
4.A Case of Giant Neurofibroma Arising from the Scalp.
Youn Kyoung DO ; Jun Yeon HWANG ; Young Ho HONG ; Seog Kyun MUN
Korean Journal of Otolaryngology - Head and Neck Surgery 2009;52(10):833-836
Neurofibromatosis 1 (NF-1) is an inherited neurocutaneous disorder arising from the chromosome 17q with a prevalence of one in 4,000. Neurofibroma, Cafe-au-lait spots, freckles in axilla, Lisch nodule and bony dysplasia are features of NF-1. It is diagnosed preoperatively by history taking, physical examination, CT, MRI and intraoperatively by tissue biopsy. Scalp neurofibroma accompanying pain, motor disturbance, rapid growth, and suspicious of malignancy are indications for surgical removal. We present a case of NF-1 with two giant neurofibromas (15x7x4 cm, 3x5x2 cm) on the left scalp in a patient suffering from a head injury after falling down. The neurofibromas were successfully removed after diagnosed by MRI and histology.
Axilla
;
Biopsy
;
Cafe-au-Lait Spots
;
Craniocerebral Trauma
;
Humans
;
Melanosis
;
Neurocutaneous Syndromes
;
Neurofibroma
;
Neurofibromatosis 1
;
Physical Examination
;
Prevalence
;
Scalp
;
Stress, Psychological
5.Sudden Hearing Loss Caused by Acute Pontine Infarction: Reports of Two Cases.
Seog Kyun MUN ; Gyu Ho LEE ; Youn Kyoung DO ; Young Ho HONG
Korean Journal of Otolaryngology - Head and Neck Surgery 2008;51(7):650-654
In most cases, sudden deafness results from viral infection, vascular occlusion or cochlear membrane rupture, but occasionally, its central origin can not be excluded. Although a number of signs are theoretically plausible in patients with pontine infarction such as facial weakness, lateral gaze palsy, Horner syndrome, limb dysmetria, crossed sensory loss or vertigo, isolated sudden deafness is a very rare manifestation. When pontine infarction occurs, it is usually identified on T2-weighted and diffusion-weighted magnetic resonance imaging (MRI). Early treatment with anticoagulant and antiplatelet agents leads to a more rapid resolution of symptoms and preservation of existing brain function. Recently, the authors have experienced two cases of sudden hearing loss caused by acute pontine infarction. Hence, we report two cases with a review of literature.
Brain
;
Brain Stem Infarctions
;
Cerebellar Ataxia
;
Extremities
;
Hearing Loss, Sudden
;
Horner Syndrome
;
Humans
;
Infarction
;
Magnetic Resonance Imaging
;
Membranes
;
Paralysis
;
Platelet Aggregation Inhibitors
;
Pons
;
Rupture
;
Vertigo
6.A Case of Schwannoma Arising in Pterygopalatine Fossa.
Seog Kyun MUN ; Hang Sun CHO ; Youn Kyoung DO ; Young Ho HONG
Korean Journal of Otolaryngology - Head and Neck Surgery 2008;51(6):552-555
Schwannoma, also referred to as neurilemmoma, is an encapsulated benign soft tissue tumor arising from the schwann cells of the nerve sheath. Although 25 to 45% of schwannomas arise in the head and neck region, pterygopalatine fossa is the rarest sites of involvement with only 23 cases reported in the medical literature. It is usually seen in the second and fifth decades, but sex or racial predilection has not been noted. Clinical features of this tumor are dependent on the involved anatomical site, nerve of origin, and compression of adjacent structures. The differential diagnosis of masses in pterygopalatine fossa includes angiofibroma, fibrous histiocytoma, malignant melanoma, lymphoma, and low-grade rhabdomyosarcoma. The treatment of choice is that the tumor is completely removed with careful preservation of its nerve. Recently, the authors experienced a case of schwannoma arising in pterygopalatine fossa, which was removed with transantral approach. Hence, we report a rare case with a review of literature.
Angiofibroma
;
Diagnosis, Differential
;
Head
;
Histiocytoma, Malignant Fibrous
;
Lymphoma
;
Melanoma
;
Neck
;
Neurilemmoma
;
Pterygopalatine Fossa
;
Rhabdomyosarcoma
;
Schwann Cells
7.Effect of Human Immunoglobulin G in Pneumoconiotic Patients with Pneumonia.
Je Hyuk MUN ; Jin Suk CHUNG ; Kyoung Ah KIM ; Young LIM ; Ho Woo NAM ; Joong Soo HAN
Korean Journal of Occupational and Environmental Medicine 2002;14(2):134-142
OBJECTIVES: It is well known that pneumoconiotic patients experience impairments of macrophage function, as well as poor penetration of drugs into the fibrotic nodules and the immune system. Resultantly, pneumonia is frequently involved in pneumoconiotic patients and its treatment is not easy. Therefore, we conducted a clinical evaluation of immunoglobulin G which is known to be effective in severe infectious diseases. METHODS: We randomly selected 45 pneumoconiotic patients with pneumonia and classified them into 2 groups. The experimental group (IgG group) was scheduled to receive antibiotics and IgG (5 g I.V./day for 7 days). The control group was treated with antibiotics alone. Sputum gram stain (counts of WBCs and microorganisms), body temperature, arterial oxygen tension, and counts of peripheral venous blood leukocytes and band neutrophils were used as markers to assess the response effect therapy at time periods of 0, 2, 4, 6, and 8 days after completion of therapy. We compared the clinical scores between the two groups. RESULTS: The experimental IgG treated group was composed of 27 patients, and the control group comprised 18 patients. There was no statistical differences between two groups in terms of age, pneumoconiotic profusion, impairment degree of pulmonary function, or frequency of pathogen isolation in the sputum before medication. The experimental IgG treated group showed lower clinical scores as compared with the control group (p=0.083). CONCLUSIONS: These results suggest that IgG infusion with antibiotics will have an effect on pneumonia therapy in pneumoconiosis patients that are under 60 years and exhibit simple pneumoconiosis.
Anti-Bacterial Agents
;
Body Temperature
;
Communicable Diseases
;
Humans*
;
Immune System
;
Immunoglobulin G*
;
Immunoglobulins*
;
Leukocytes
;
Macrophages
;
Neutrophils
;
Oxygen
;
Pneumoconiosis
;
Pneumonia*
;
Sputum
8.A Case of Reversible Ischemic Colitis in a Young Woman.
Eun Young KIM ; Chung Kyoung CHOI ; Young Jin KIM ; Young Chul SO ; Hyo Jun KIM ; Young Min SHIN ; Han Kyu MUN
Korean Journal of Gastrointestinal Endoscopy 1999;19(1):125-129
Therefore differential diagnosis from idiopathic ulcerative colitis will be needed. Recently, we have examined a 20 year-old Korean female patient who had the complaints of acute lower abdominal pain and bloody diarrhea. The diagnosis of ischemic colitis was confirmed on the basis of colonoscopic and associated histopathological findings. The patient dis-charged with good improvement on the thirteenth hospital day after medical treatment with antibiotics, fluid and electrolytes. We report a case of reversible ischemic colitis of descend-ing colon of a young woman with literature review.
Abdominal Pain
;
Anti-Bacterial Agents
;
Colitis, Ischemic*
;
Colitis, Ulcerative
;
Colon
;
Diagnosis
;
Diagnosis, Differential
;
Diarrhea
;
Electrolytes
;
Female
;
Humans
;
Young Adult
9.Two cases of advanced hepatocellular carcinoma achieving a complete response with metronomic chemotherapy via the hepatic artery.
Yeon Joo CHUN ; Si Hyun BAE ; Mun Kyoung CHUNG ; Jong Young CHOI ; Seung Kew YOON ; Ho Jong CHUN ; Byung Gil CHOI
Korean Journal of Medicine 2010;78(6):741-746
Advanced hepatocellular carcinoma (HCC) has a poor prognosis and few effective therapies. Recently, low-dose antiangiogenic (also called metronomic) chemotherapy has been tested in patients with advanced HCC. Here, we report two patients with advanced HCC who showed a good response after metronomic chemotherapy. The first was a 54-year-old man who was diagnosed with advanced HCC with lung metastasis. After three cycles of metronomic chemotherapy, the size of tumor and pulmonary metastatic lesions had decreased markedly on follow-up computed tomography. The second was a 54-year-old woman who was diagnosed with HCC with portal vein thrombosis. Metronomic therapy was performed. After 9 months, tumor enhancement in the arterial phase had disappeared completely, and the portal vein thrombus was decreased slightly. Metronomic therapy is an interesting treatment option for patients with advanced HCC. More clinical data and studies are needed to confirm this result.
Carcinoma, Hepatocellular
;
Female
;
Follow-Up Studies
;
Hepatic Artery
;
Humans
;
Lung
;
Middle Aged
;
Neoplasm Metastasis
;
Portal Vein
;
Prognosis
;
Thrombosis
10.A case of adrenocortical adenoma clinically mimicking pheochromocytoma.
Mun Kyung CHUNG ; Yong Cheol KIM ; Eun Kyoung JEON ; Keun Ho LEE ; Lee So MAENG ; Je Ho HAN ; Sung Dae MOON
Korean Journal of Medicine 2008;75(4):479-483
The coexpression of cortical and medullary features in a single adrenal cortical cell has been recognized, leading to terms such as cortico-medullary cells. Here, we reported a case of adrenocortical adenoma consisting of cortico-medullary cells that clinically mimicked pheochromocytoma. A 52-year-old woman was admitted to our hospital complaining of an 8-month history of paroxysmal palpitation with refractory hypertension. A 24-hour urine study revealed increased norepinephrine and metanephrine levels. Computed tomography of the abdomen revealed a 1.0x0.9-cm mass in the left adrenal gland. The patient subsequently underwent unilateral laparoscopic adrenalectomy for a presumptive pheochromocytoma. Light microscopic findings of the left adrenal mass indicated an adrenocortical adenoma, but electron microscopy identified lipid vacuoles and smooth endoplasmic reticulum, along with dense core neurosecretory granules, so-called cortico-medullary cells. This is the first report of the detection of cortico-medullary cells in adrenocortical adenoma presenting as pheochromocytoma in Korea.
Abdomen
;
Adrenal Glands
;
Adrenalectomy
;
Adrenocortical Adenoma
;
Endoplasmic Reticulum, Smooth
;
Female
;
Humans
;
Hypertension
;
Light
;
Metanephrine
;
Microscopy, Electron
;
Middle Aged
;
Norepinephrine
;
Pheochromocytoma
;
Vacuoles