3.IgA Type Multiple Myeloma, Clinical Features, and Prognosis.
Ling WANG ; Feng-Yan JIN ; Ying LI ; Jing-Nan SUN ; Jia-Jia ZHANG ; Ran TANG ; Yu-Ping ZHONG
Chinese Medical Journal 2018;131(10):1249-1250
4.Auto-hematopoietic stem cell transplantation for multiple myeloma accompanied with amyloidosis in four limbs.
Hui-Hui SONG ; Bao-An CHEN ; Jia-Hua DING ; Chong GAO ; Yu-Qin TAO ; Jing WANG ; Jun WANG ; Gang ZHAO ; Yun-Yu SUN ; Jian CHENG ; Wen BAO
Journal of Experimental Hematology 2009;17(3):770-773
The study was aimed to investigate the effective therapeutic method for patients with multiple myeloma accompanied with amyloidosis. A 58-year-old patient diagnosed as multiple myeloma accompanied with amyloidosis in four limbs was enrolled in this study. The various clinical and laboratorial examinations were performed, including bone marrow smear, immunologic test, radiography and so on. Patient received chemotherapeutic drugs and then autologous hematopoietic stem cell transplantation (auto-HSCT). The result showed that hematopoietic reconstitution was achieved at 23 days after auto-HSCT. Immunofixation electrophoresis was normal. There was only 0.6% plasma cells in the bone marrow. In conclusion, the auto-HSCT may be an effective treatment for multiple myeloma accompanied with amyloidosis in four limbs.
Amyloidosis
;
complications
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
Male
;
Middle Aged
;
Multiple Myeloma
;
complications
;
surgery
;
Transplantation, Autologous
5.Research Advances on Treatment of Multiple Myeloma Bone Disease--Review.
Zu-Yao XIA ; Hui-Juan YANG ; Bao-An CHEN
Journal of Experimental Hematology 2016;24(1):275-278
The main features of multiple myeloma bone disease (MBD) are hyperactivity of systemic bone destruction and inhibition of new bone formation. Its clinical manifestations include pain, osteoporosis, pathologic fractures and associated nerve compression symptoms etc. MBD is one of the most common complications of multiple myeloma (MM). Its misdiagnosis rate is higher, and the patients' quality of life and prognosis are poor. This review discusses the most recent advancement on its pathogenesis and novel therapies, so as to provide reference for clinical treatment of MBD.
Bone Diseases
;
complications
;
therapy
;
Humans
;
Multiple Myeloma
;
complications
;
therapy
;
Prognosis
;
Quality of Life
8.Clinical Characteristics and Prognosis of Multiple Myeloma Patients with Myelofibrosis.
Lu CHENG ; Li-Min SONG ; Ru XUE ; Yan-Ping MA
Journal of Experimental Hematology 2022;30(1):141-145
OBJECTIVE:
To investigate the clinical characteristics and prognosis of multiple myeloma patients with myelofibrosis.
METHODS:
The clinical data of 263 patients with multiple myeloma (including 92 patients with myelofibrosis) treated in the department of hematology of our hospital from January 1, 2016 to June 31, 2020 were collected and retrospectively analyzed, the patients were divided into combined group and uncombined group. The MM stage, MM type, genetic characteristics and therapeutic effect of the patients in combined group and uncombined group were observed, and the relationship between the curative effect and the degree of myelofibrosis change of the patients in combined group was analyzed.
RESULTS:
There was no statistically difference in the MM staging and classification between multiple myeloma patients with or without myelofibrosis (P>0.05). The positive rate of FISH results of the patients in combined group was significantly higher than those in uncombined group, and was significantly correlated to 1q21 amplification, D13S319 deletion, and IgH breakage (P<0.05). After treatment, the effective rate of the patients in uncombined group was significantly higher than those in combined group, and the degree of fibrosis in the effective patients in combined group was significantly reduced.
CONCLUSION
The survival rate of the patients with multiple myeloma complicated with myelofibrosis is shorter than that of the patients without myelofibrosis, and the overall prognosis is poor.
Chromosome Aberrations
;
Humans
;
Multiple Myeloma/complications*
;
Primary Myelofibrosis/complications*
;
Prognosis
;
Retrospective Studies
9.Xanthoma of the liver in a patient with multiple myeloma associated with hyperlipidemia: A case report.
Hyunee YIM ; Hee Jeong AHN ; Chanil PARK ; Jae Yoon CHEON
Journal of Korean Medical Science 1995;10(6):453-456
A case of xanthoma of the liver in a 61-year-old Korean woman with multiple myeloma, hyperlipidemia and xanthoma of the skin is described. Microscopically, the liver showed a multiple xanthomatous collection of foamy histiocytes as well as diffuse sinusoidal infiltration of the foam cells. This hepatic accumulation of foam cells seems to be related to hyperlipidemia of the patient. The mechanism of hyperlipidemia in multiple myeloma is discussed.
Case Report
;
Female
;
Human
;
Hyperlipidemia/blood/*complications
;
Liver Diseases/blood/*complications
;
Middle Age
;
Multiple Myeloma/blood/*complications
;
Xanthomatosis/blood/*complications
10.The Risk and Survival Analysis of Multiple Malignancies in Hematologic Malignancy Patients: A Single Chinese Center Retrospective Study, 2009 through 2017.
Xu-Chang ZHANG ; Lei FAN ; Hua LU ; Si-Xuan QIAN ; Li-Juan CHEN ; Wei XU ; Jian-Yong LI ; Xiao-Yan QU ; Xiao-Li ZHAO
Journal of Experimental Hematology 2023;31(2):389-395
OBJECTIVE:
To explore the risk and location of multiple malignancies in patients with hematologic malignancies who were followed up for 9 years in Jiangsu Province Hospital and to evaluate the impact of the second primary malignancy on survival of patients.
METHODS:
The incidence and survival of multiple malignancies in 7 921 patients with hematologic malignancies from 2009 to 2017 were analyzed retrospectively.
RESULTS:
A total of 180 (2.3%, 180/7 921) patients developed second malignancy, of whom 58 patients were diagnosed with hematologic malignancies as the first primary malignancy, and 98 patients developed hematologic malignancies as second primary malignancy, and the other 24 cases were diagnosed with the second malignancy within 6 months after the first primary malignancy was diagnosed, which was difined as multiple malignancies occurring simultaneously. In 180 patients, 18 cases developed two hematologic malignancies successively, and 11 patients developed more than 3 primary cancers (among them, 2 female patients were diagnosed with 4 primary cancers). Patients with lymphoma and multiple myeloma (MM) as the second primary malignancy had poorer survival than patients with lymphoma and MM as the first primary malignancy. Patients with chronic myeloid leukemia as the second primary malignancy were also associated with inferior overall survival.
CONCLUSION
In this study, 2.3% of hematologic malignancy patients had multiple mali-gnancies, lymphoma and MM as the second primary malignancy had poor survival.
Humans
;
East Asian People
;
Hematologic Neoplasms/complications*
;
Lymphoma/complications*
;
Multiple Myeloma/complications*
;
Neoplasms, Second Primary
;
Retrospective Studies
;
Survival Analysis