3.Bilateral polychromatic crystalline keratopathy as the initial manifestation of IgG-lambda multiple myeloma.
Fong Yee FOO ; Christopher KHNG ; Li Wern VOON
Annals of the Academy of Medicine, Singapore 2013;42(2):93-94
Adult
;
Corneal Diseases
;
diagnosis
;
etiology
;
Humans
;
Male
;
Multiple Myeloma
;
complications
;
diagnosis
4.POEMS syndrome: a case report.
Jae Woo KIM ; Sang Kun LEE ; Kyung Min HA ; Ki Ho KIM ; Gwang Yeol JOH ; Hyo Jin KIM ; Seoung Oh YANG ; Sook Hee HONG
Journal of Korean Medical Science 1992;7(1):79-84
POEMS syndrome is a multisystem disorder associated with polyneuropathy, organomegaly, endocrinopathy, a monoclonal protein (M-protein), and skin changes. The authors describe a patient with POEMS syndrome who had osteosclerotic myeloma confirmed by open bone biopsy. Magnetic resonance imaging (MRI) showed discrete lesions of low signal intensity in both T1 and T2-weighted images. This patient is now being successfully treated with melphalan and prednisone with much improvement in skin thickening and sensory change in the lower extremities.
Adult
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Biopsy
;
Femur Neck/pathology
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Multiple Myeloma/complications/pathology
;
POEMS Syndrome/complications/*diagnosis
5.Newly Developed Multiple Myeloma in a Patient with Primary T-Cell Lymphoma of Bone.
Jun Eul HWANG ; Sang Hee CHO ; Ok Ki KIM ; Hyun Jeong SHIM ; Se Ryeon LEE ; Jae Sook AHN ; Duk Hwan YANG ; Yeo Kyeoung KIM ; Je Jung LEE ; Hyeoung Joon KIM ; Ik Joo CHUNG
Journal of Korean Medical Science 2008;23(3):544-547
Primary non-Hodgkin's lymphoma of bone (PLB) is rare, and generally presents as a single extensive and destructive bone lesion. Histopathologically, most cases present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast, multiple myeloma is a disease defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. We report a case of multiple myeloma that developed during treatment of PLB in a type of T-cell. A 48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient received the chemoradiotherapy and salvage chemotherapy for PLB. However, the lymphoma progressed with generalized bone pain, and laboratory findings showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient was diagnosed as having multiple myeloma newly developed with primary T-cell lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.
Bone Neoplasms/*complications/diagnosis/therapy
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Fatal Outcome
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Humans
;
Kidney Failure, Acute/etiology
;
Lymphoma, T-Cell/*complications/diagnosis/therapy
;
Male
;
Middle Aged
;
Multiple Myeloma/*complications/diagnosis/therapy
6.Immunoglobulin D lambda multiple myeloma: a case report.
Shu-Kai QIAO ; Xue-Jun ZHANG ; Fu-Xu WANG ; Ling PAN ; Li YAO ; Zuo-Ren DONG
Journal of Experimental Hematology 2007;15(3):643-646
To improve the recognition of immunoglobulin D multiple myeloma and explore its clinical feature and laboratory examination characteristics, so as to reduce the the missed diagnosis and misdiagnosis, a case of IgD multiple myeloma (MM) with myelofibrosis and bone marrow necrosis is reported. The clinical feature, treatment and prognosis of IgDlambda MM were discussed. Immunoglobulin D multiple myeloma is a rare disease and predominantly occurs in young male patients, which shows an aggressive clinical course with poor response to conventional treatment and unfavorable prognosis. Immunoglobulin D multiple myeloma was usually misdiagnosed as a light chain type multiple myeloma by using routine laboratory examination. Immunoglobulin D monoclonal protein is not easy to be detected owing to its low protein level, resulting in missed diagnosis. Immunofixation electrophoresis is highly sensitive and specific for diagnosis of IgD MM, can enhance accuracy of diagnosis for this rare disease.
Adult
;
Diagnosis, Differential
;
Humans
;
Immunoglobulin D
;
blood
;
Immunoglobulin lambda-Chains
;
blood
;
Male
;
Multiple Myeloma
;
blood
;
complications
;
diagnosis
;
Primary Myelofibrosis
;
blood
;
complications
;
diagnosis
7.Clinical and laboratory features of newly diagnosed multiple myeloma: a retrospective, single-centre analysis.
Yu-jie MAI ; Pei-jing QI ; Yan XU ; De-hui ZOU ; Ya-fei WANG ; Yao-zhong ZHAO ; Ren-chi YANG ; Zhi-jian XIAO ; Lu-gui QIU
Chinese Medical Journal 2007;120(19):1727-1729
Adult
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Aged
;
Aged, 80 and over
;
Bone Marrow Examination
;
Female
;
Humans
;
Male
;
Middle Aged
;
Multiple Myeloma
;
complications
;
diagnosis
;
mortality
;
Prognosis
;
Retrospective Studies
8.Complications of Allograft Reconstruction following Wide Resection of Malignant Bone Tumors in Long Bones.
Kap Jung KIM ; Sang Ki LEE ; Chung Youb JEON ; Chang Hyun MA ; Su Min KIM
The Journal of the Korean Orthopaedic Association 2018;53(3):264-270
PURPOSE: We evaluated the results of allograft reconstruction following wide resection of malignant bone tumors in long bone, retrospectively. MATERIALS AND METHODS: Seven patients were included. The mean age was 44 years old. Male was 4 cases, and female was 3 cases. Mean follow-up period was 38 months. The mean Musculoskeletal Tumor Society (MSTS) score at final follow-up was evaluated. Postoperative complications were evaluated via periodic radiologic follow-up. Oncologic results were analyzed at final follow-up. RESULTS: The primary malignancies occurred at femur in 5 cases, humerus in 1 case and tibia in 1 case. Pathologic diagnoses were osteosarcoma in 4 cases, multiple myeloma in 2 cases and adamantinoma in 1 case. Mean length of allograft was 165 mm. Fixations of allograft were intramedullary nailing with additional plate in 4 cases, intramedullary nailing in 2 cases, and screw fixation in 1 case. Mean time to union was 14.5 weeks. Mean MSTS score at final follow-up was 20 (67%). Postoperative complications were nonunion in 3 cases, implant failure in 1 case, and infection in 1 case. Oncologic outcomes were continuous disease free in 5 cases and alive with disease in 2 cases at final follow-up. Autologous bone graft and hemi-cortical onlay graft were performed in 2 cases of nonunion. CONCLUSION: Allograft reconstruction following wide resection of malignant bone tumors in long bone was effective surgical option. However, the possibility of nonunion between host bone and allograft should be considered.
Adamantinoma
;
Allografts*
;
Diagnosis
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Female
;
Femur
;
Follow-Up Studies
;
Fracture Fixation, Intramedullary
;
Humans
;
Humerus
;
Inlays
;
Male
;
Multiple Myeloma
;
Osteosarcoma
;
Postoperative Complications
;
Retrospective Studies
;
Tibia
;
Transplants
9.A Case of Acute Promyelocytic Leukemia Concomitant with Plasma Cell Myeloma.
Jinsook LIM ; Gye Cheol KWON ; Sun Hoe KOO ; Ik Chan SONG ; Jimyung KIM
Annals of Laboratory Medicine 2014;34(2):152-154
No abstract available.
Blood Cell Count
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Bone Marrow Cells/metabolism/pathology
;
Humans
;
Leukemia, Promyelocytic, Acute/complications/*diagnosis/pathology
;
Magnetic Resonance Imaging
;
Male
;
Middle Aged
;
Multiple Myeloma/complications/*diagnosis/pathology
;
Paraproteinemias/diagnosis
;
Syndecan-1/metabolism
10.A Case of Non-secretory Myeloma with Crystal-storing Histiocytosis.
Soon Ho PARK ; Jeong Yeal AHN ; Yiel Hea SEO ; Pil Hwan PARK ; Kyung Hee KIM ; Young Hee SONG ; Ji Hun JEONG ; Jae Hoon LEE
The Korean Journal of Laboratory Medicine 2010;30(6):580-584
Crystal-storing histiocytosis (CSH) is a rare event observed in association with lymphoproliferative diseases, and mainly occurrs in plasma cell dyscrasias. It is presumed to be an intra-lysosomal accumulation of the secreted paraproteins. Crystal formation can be seen inside histiocyte-like cells with phagocytosed crystalline inclusions in the bone marrow and extramedullary sites. CSH is a rare morphological entity with poor prognostic implications and may be confused with Gaucher or pseudo-Gaucher cells. Herein we report a case of non-secretory myeloma associated with CSH showing a poor clinical course. A 79-yr-old male presenting with dizziness was evaluated in hematology department for anemia. Laboratory tests revealed Hb of 4.9 g/dL and beta2-microglobulin of 21,000 ng/mL (reference range, 0-370). Presence of monoclonal protein was not detected on protein electrophoresis and immunofixation in serum and urine. However, serum free light chain assay showed an increased kappa-light chain level of 126 mg/L (reference range, 3.3-19.4) resulting in an increased kappa/lambda ratio. The bone marrow touch print showed numerous plasma cells and crystal-laden histiocytes and immunohistochemical stainings on bone marrow biopsy revealed positivity for CD38, CD56 and kappa in the plasma cells and CD68 and kappa in crystal-laden histiocytes.
Aged
;
Antigens, CD/metabolism
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Antigens, CD38/metabolism
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Antigens, Differentiation, Myelomonocytic/metabolism
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Bone Marrow Cells/pathology
;
Histiocytosis/complications/*diagnosis/radiography
;
Humans
;
Immunoglobulin kappa-Chains/analysis
;
Male
;
Multiple Myeloma/complications/*diagnosis/radiography
;
Tomography, X-Ray Computed