2.Newly Developed Multiple Myeloma in a Patient with Primary T-Cell Lymphoma of Bone.
Jun Eul HWANG ; Sang Hee CHO ; Ok Ki KIM ; Hyun Jeong SHIM ; Se Ryeon LEE ; Jae Sook AHN ; Duk Hwan YANG ; Yeo Kyeoung KIM ; Je Jung LEE ; Hyeoung Joon KIM ; Ik Joo CHUNG
Journal of Korean Medical Science 2008;23(3):544-547
Primary non-Hodgkin's lymphoma of bone (PLB) is rare, and generally presents as a single extensive and destructive bone lesion. Histopathologically, most cases present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast, multiple myeloma is a disease defined as the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. We report a case of multiple myeloma that developed during treatment of PLB in a type of T-cell. A 48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient received the chemoradiotherapy and salvage chemotherapy for PLB. However, the lymphoma progressed with generalized bone pain, and laboratory findings showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient was diagnosed as having multiple myeloma newly developed with primary T-cell lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.
Bone Neoplasms/*complications/diagnosis/therapy
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Fatal Outcome
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Humans
;
Kidney Failure, Acute/etiology
;
Lymphoma, T-Cell/*complications/diagnosis/therapy
;
Male
;
Middle Aged
;
Multiple Myeloma/*complications/diagnosis/therapy
3.Extramedullary relapse of multiple myeloma presenting as massive upper gastrointestinal bleeding: a rare complication.
Bulent YASAR ; Pembegul GUNES ; Ozgur GULER ; Selma YAGCI ; Dilek BENEK
The Korean Journal of Internal Medicine 2015;30(4):538-539
No abstract available.
Aged
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Antigens, CD38/analysis
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Biomarkers, Tumor/analysis
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Biopsy
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Gastrointestinal Hemorrhage/diagnosis/*etiology/therapy
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Gastroscopy
;
Hematemesis/etiology
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Humans
;
Immunohistochemistry
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Male
;
Melena/etiology
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Membrane Glycoproteins/analysis
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Multiple Myeloma/*complications/immunology/pathology/therapy
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Recurrence
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Stomach Neoplasms/*complications/immunology/pathology/therapy
4.Multiple Myeloma with Biclonal Gammopathy Accompanied by Prostate Cancer.
Nae Yu KIM ; Soo Jung GONG ; Jimyung KIM ; Seon Min YOUN ; Jung Ae LEE
The Korean Journal of Laboratory Medicine 2011;31(4):285-289
We report a rare case of multiple myeloma with biclonal gammopathy (IgG kappa and IgA lambda type) in a 58-year-old man with prostate cancer who presented with lower back pain. Through computed tomography (CT) imaging, an osteolytic lesion at the L3 vertebra and an enhancing lesion of the prostate gland with multiple lymphadenopathies were found. In the whole body positron emission tomography-computed tomography (PET-CT), an additional osteoblastic bone lesion was found in the left ischial bone. A prostate biopsy was performed, and adenocarcinoma was confirmed. Decompression surgery of the L3 vertebra was conducted, and the pathologic result indicated that the lesion was a plasma cell neoplasm. Immunofixation electrophoresis showed the presence of biclonal gammopathy (IgG kappa and IgA lambda). Bone marrow plasma cells (CD138 positive cells) comprised 7.2% of nucleated cells and showed kappa positivity. We started radiation therapy for the L3 vertebra lesion, with a total dose of 3,940 cGy, and androgen deprivation therapy as treatment for the prostate cancer.
Adenocarcinoma/complications/*diagnosis/radiotherapy
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Antineoplastic Agents/therapeutic use
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Bone Marrow Cells/metabolism/pathology
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Combined Modality Therapy
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Humans
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Immunoelectrophoresis
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Immunoglobulin kappa-Chains/blood
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Immunoglobulin lambda-Chains/blood
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Male
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Middle Aged
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Multiple Myeloma/complications/*diagnosis/drug therapy
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Neoplasm Staging
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Positron-Emission Tomography
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Prostatic Neoplasms/complications/*diagnosis/radiotherapy
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Spine/pathology
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Syndecan-1/metabolism
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Tomography, X-Ray Computed
5.A Rare Case of Chronic Myelogenous Leukemia and Plasma Cell Myeloma in the Same Patient.
Sunhyun AHN ; Joon Seong PARK ; Jae Ho HAN ; Sung Ran CHO
Annals of Laboratory Medicine 2015;35(3):370-372
No abstract available.
Aged
;
Antineoplastic Agents/therapeutic use
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Bone Marrow/pathology
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Fusion Proteins, bcr-abl/genetics/metabolism
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Humans
;
Imatinib Mesylate/therapeutic use
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications/*diagnosis/drug therapy
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Leukocyte Count
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Male
;
Multiple Myeloma/complications/*diagnosis/drug therapy
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Platelet Count
;
Polymerase Chain Reaction
;
Thrombocytosis/etiology