Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited syndrome with characteristic clinical and radiological manifestations. Many reports on MEN1 have been published; however, no cases of radiologically diagnosed MEN1 have been reported. Therefore, we report on a radiologically diagnosed case of MEN1 with clinical symptoms of gastroduodenal ulcer.
Multiple Endocrine Neoplasia ; Multiple Endocrine Neoplasia Type 1 ; Peptic Ulcer ; Pituitary Neoplasms

OBJECTIVES: The Beck Depression Inventory (BDI) is one of the most widely used self-report measures of depression in both research and clinical practice. The Beck Depression Inventory Second Edition (BDI-II) is the most recent version of the BDI. Validity of the BDI-II has been documented in other countries. This study examined the factor structure of the Korean version of BDI-II in a large sample of university students. METHOD: Data were obtained from 2,529 students of Kongju National University. The factor structures of the Korean version of BDI-II were assessed using exploratory and confirmatory factor analysis. RESULTS: A high level of internal consistency and reliability (Cronbach's alpha = 0.91) and item homogeneity was confirmed. Exploratory factor analysis showed a two-factor structure (cognitive and somatic-affective), which was almost identical to the original model demonstrated by Beck et al. The following confirmatory factor analysis also supported the two-factor structure (cognitive and somatic-affective) is a better fit than the other two-factor structure (cognitive-affective and somatic). The higher mean score for women compared to men is consistent with the results of previous reports. CONCLUSION: These data support the reliability and concurrent validity of the Korean version of BDI-II as a measure of depressive symptoms in nonclinical samples.
Depression ; Female ; Humans ; Multiple Endocrine Neoplasia Type 1

Multiple endocrine neoplasia (MEN) is defined as a disorder with neoplasms in two or more different hormonal tissues in several members of a family. MEN1, or Wermer's syndrome, is inherited as an autosomal dominant trait. This syndrome is characterized by neoplasia of the parathyroid glands, enteropancreatic tumors, anterior pituitary adenomas, and other neuroendocrine tumors with variable penetrance. Inherited medullary thyroid carcinoma (MTC) consists of MEN2A, MEN2B, and familial medullary thyroid cancer (FMTC). The identification of hereditary MTC has been facilitated in recent years by direct analysis of germline RET proto-oncogene mutation.
Carcinoma, Medullary ; Humans ; Multiple Endocrine Neoplasia ; Multiple Endocrine Neoplasia Type 1 ; Multiple Endocrine Neoplasia Type 2a ; Multiple Endocrine Neoplasia Type 2b ; Neuroendocrine Tumors ; Parathyroid Glands ; Penetrance ; Pituitary Neoplasms ; Proto-Oncogenes ; Thyroid Gland ; Thyroid Neoplasms

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of two or more endocrine tumors such as pituitary, parathyroid, and pancreatic islet tumors. Treatment is needed for tumors accompanied by symptoms or having malignant potential. Malignant neuroendocrine tumors (NETs) are the major cause of MEN1-related death, and pancreatic NETs account for 30-80% of MEN1 cases. Surgery is the mainstay curative treatment, and endoscopic intervention is a treatment option when patients are poor candidates for surgery. A 33-year old female patient with MEN1 was treated via endoscopic ultrasonography-guided ethanol injection for a pancreatic NET.
Chromosomes, Human, Pair 1 ; Endosonography ; Ethanol* ; Female ; Humans ; Islets of Langerhans ; Multiple Endocrine Neoplasia Type 1* ; Multiple Endocrine Neoplasia* ; Neuroendocrine Tumors* ; Pancreas

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder caused by mutations in the MEN1 gene on chromosome 1. Clinical diagnostic criteria for MEN1 include the presence of two or more endocrine tumors such as pituitary, parathyroid, and pancreatic islet tumors. Treatment is needed for tumors accompanied by symptoms or having malignant potential. Malignant neuroendocrine tumors (NETs) are the major cause of MEN1-related death, and pancreatic NETs account for 30-80% of MEN1 cases. Surgery is the mainstay curative treatment, and endoscopic intervention is a treatment option when patients are poor candidates for surgery. A 33-year old female patient with MEN1 was treated via endoscopic ultrasonography-guided ethanol injection for a pancreatic NET.
Chromosomes, Human, Pair 1 ; Endosonography ; Ethanol* ; Female ; Humans ; Islets of Langerhans ; Multiple Endocrine Neoplasia Type 1* ; Multiple Endocrine Neoplasia* ; Neuroendocrine Tumors* ; Pancreas

During the past three decades, several reports have suggested that the quality of semen in men is declining. The chance of exposure to environmental toxin tends to increase but most of gonadotoxic agents are not clearly known. We report five patients with secondary transient or permanent reduction of sperm numbers. The possible causes are discussed.
Humans ; Infertility ; Infertility, Male* ; Male ; Male* ; Multiple Endocrine Neoplasia Type 1 ; Semen ; Sperm Count

Familial isolated primary hyperparathyroidism (FIHP) is an autosomal dominant disorder that is characterized by an early stage of either multiple endocrine neoplasia type 1 (MEN1) or hyperparathyroidism-jaw tumor (HPT-JT) syndrome. We report here on a case of a 42-years old woman who was diagnosed with papillary thyroid cancer and primary hyperparathyroidism. Her younger brother also had primary hyperparathyroidism. On the genetic analysis, they were both proven to have a novel frameshift mutation in the MEN1 gene (exon 10).
Female ; Frameshift Mutation ; Humans ; Hyperparathyroidism, Primary ; Multiple Endocrine Neoplasia Type 1 ; Siblings ; Thyroid Neoplasms

PURPOSE: Electrically evoked potential (EEP) was recorded in rabbits with polyimide-based, multichannel, microelectrode array (MEA) in their eyes, and was compared with the visual evoked potential (VEP) by flash light. METHODS: VEP was recorded under full-field flash light stimulation by 0. 6 J at 2 Hz, while EEP was recorded under electrical current stimulation of the retina by MEA. Latencies and shapes of N1, P100 and N2 in each evoked potential were compared. RESULTS: EEP was recorded in four of six rabbits. N1, P100 and N2 were observed in EEP on the electrical retina stimulation over 2.5 mA, and they resembled those of VEP. However, N1, P100 and N2 of EEP showed shorter latencies than those of VEP, by 15.1 msec (32.9%), 76.8 msec (38.3%) and 99.7 msec (60.1%) respectively. CONCLUSIONS: EEP by electrical retina stimulation with MEA was similar to VEP, indicating that MEA is suitable for the development of the artificial retina prototype. The shorter latencies of EEP should be considered in the parameters of the electrical stimulation of the retina.
Electric Stimulation ; Evoked Potentials* ; Evoked Potentials, Visual ; Microelectrodes ; Multiple Endocrine Neoplasia Type 1 ; Rabbits* ; Retina ; Retinaldehyde*

Medical examinations for aircrew (MEA) have been applied in various extents since World War I, when medical fitness of aircrew began to be spotlighted as a major factor of flight safety and flight performance. The main purpose of MEA is to identify any presumptive medical defects that may cause sudden incapacitation and aircraft accident consequently. However, the value of medical screening tests has been debated for many years and raised questions of their effectiveness and aeromedical usefulness. Therefore, this review article focuses on diverse perspectives regarding MEA and tries to develop the most appropriate way of implementing medical examinations for insuring flight safety.
Aircraft ; Mass Screening ; Multiple Endocrine Neoplasia Type 1 ; World War I

Although the incidence of urinary incontinence in men is lower than in women, the prevalence of male incontinence shows increasing tendency with aging. The author reviewed the types, assessments, and managements of male incontinence.
Aging ; Female ; Humans ; Incidence ; Male ; Multiple Endocrine Neoplasia Type 1 ; Prevalence ; Urinary Incontinence