1.Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects.
Yan CHEN ; Chen CHEN ; Xiaojuan ZHANG ; Chuanchuan HE ; Pengxuan ZHAO ; Minsi LI ; Ting FAN ; Ruicong YAN ; Yao LU ; Robert J LEE ; Muhammad Waseem KHAN ; Muhammad SARFRAZ ; Xiang MA ; Tan YANG ; Guangya XIANG
Acta Pharmaceutica Sinica B 2020;10(6):1106-1121
Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both and . In addition, Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.
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