Two cases of natural human infection by Heterophyopsis continua (Heterophyidae) were identified by collection of adult worms in 1983 in Korea. And in order to know the source of infection a study on fish intermediate hosts was performed along the southwestern coastal areas. The cases were 24 and 50-year old males residing in southern coastal areas. They had the clinical complaints of non-specific gastrointestinal symptoms such as epigastric pain and one of them also complained the discharge of tapeworm segments. Praziquantel in single dose of 10~15 mg/kg was given followed by purgation with mangnesium salt and 2 and 46 specimens of H. continua were collected from the diarrheal stools. They said to have eaten raw flesh of several kinds of brackish water fishes. The results of fish examination for metacercarial infection were as follows: Seventeen (63.0%) out of 27 perches (Lateolabrax japonicus) and 10 (29.4%) out of 34 gobies (Acanthogobius flavimanus) harboured the metacercariae but none of 42 mullets (Mugil cephalus) were found to harbour them. The average metacercarial density in perches was 55.4 and 18.7 per fish respectively. And the majority of the metacercariae were collected from the muscle of body portions in these fishes. After the metacercariae were experimentally fed to two rats and one young dog, two adult worms were recovered from the dog while none from the rats. These worms were also indentified as H. continua. From the results it was concluded that the brackish water fishes which the human cases said to have eaten were the source of infection.
parasitology-helminth-trematoda ; Heterophyopsis continua ; case report ; Mugil cephalus ; praziquantel ; Lateolabrax japonicus ; Acanthogobius flavimanus ; epidemiology

Two human cases of Heterophyes heterophyes nocens infection were proved by identifying adult worms after treatment with bithionol or praziquantel in 1983 in Korea. They are 37 (Case 1) and 24-year old (Case 2) males whose residence or native village is a southern coastal area in Kohung-gun, Chollanam-do. The Case 1 had the gastrointestinal symptoms such as epigastric pain and indigestion, and the Case 2 heart problems such as arrhythmia and ventricular premature beat in EKG and digestive symptoms such as diarrhea and abdominal pain. After the treatments, 35 and 67 specimens of H. heterophyes nocens respectively were collected from the diarrheal stools through stereomicroscopy. The Case 1 was concommitantly infected with Clonorchis sinensis and the case 2 with 3 other kinds of heterophyid flukes and with Diphyllobothrium latum. The cases said to have eaten raw brackish water fish such as mullets (Mugil cephalus), perches (Lateolabrax japonicus) and gobies (Acanthogobius flavimanus) which are the intermediate hosts of H. heterophyes nocens in Korea.
parasitology-helminth-trematoda ; Heterophyes heterophyes nocens ; Clonorchis sinensis ; case report ; bithionol ; praziquantel ; chemotherapy ; Mugil cephalus ; Lateolabrax japonicus ; Acanthogobius flavimanus

: A study of infestation patterns for larval trematodes from fresh-water fish and brackish-water fish was carried out during the period from June to October in 1982. They were collected by netting, fishing with rod and line, and using the bait of crushed oil cake in a transparent plastic bowls at the three localities, Daebon-dong, Kugil-dong, and Hoam-dong in the river Taechong, Kyungpook Province, Korea. Five species of fresh-water fish, the crussian carp, Carassius carassius Linnaeus, the bullhead, Coreobagrus brevicorpus Mori, the fat minnow, Moroco oxycephalus (Bleeker), the flat bitterling, Paracheilognathus rhombea(Temminck et Schlegel), and the catfish, Parasilurus asotus (Linnaeus), and two kinds of brackish-water fish, the grey mullet, Mugil cephalus (Linnaeus) and the sweetfish, Plecoglossus altivelis (Temminck et Schlegel) were examined. Four species of the metacercariae, Exorchis oviformis, Metacercari hasegawai, Metorchis orientalis and undetermined larvae were found. Of these, the encysted larvae of the human intestinal fluke, Metagonimus yokogawai, were found from three kinds of fresh-water fish, the crussian carp, the bullhead and the fat minnow and one species of brackish-water fish, the sweetfish and the infestation rates for the larvae varied appreciably from fish to fish. The intensity of infestation with the Metagonimus larvae in the three species of fresh-water fish as low, and the average number of the larvae per gram of flesh varied from 0.5 to 0.2. By comparison, the brackish-water fish was more heavily infested and the mean number of cysts per gram of flesh in Plecoglossus altivelis was 109.2. It was found that infection with Metagonimus yokogawai is caused by consuming raw fresh-water fish and brackish-water fish caught in the river Taechong, Kyungpook Province, Korea.
parasitology-helminth-trematoda ; Metagonimus yokogawai ; Carassius carassius ; Coreobagrus brevicorpus ; Moroco oxycephalus ; Paracheilognathus rhombea ; Parasilurus asotus ; Mugil cephalus ; Plecoglossus altivelis ; epidemiology ; metacercaria