OBJECTIVETo study the regulative action of mica monomer powder preparation on the chief and parietal cells as well as G and D cells in the gastric mucosa of the experimental atrophic gastritis (CAG) rats.

METHODSIntervention therapy was given to the experimental CAG rats at three different doses of mica monomer powder preparation to evaluate the changes of chief and parietal cells as well as G and D cells in the gastric mucosa and the histopathological changes of gastric mucosa.

RESULTSMica monomer powder preparation at three different doses could increase the amount of chief and parietal cells as well as G and D cells in gastric mucosa of the experimental CAG rats and alleviate and control the inflammation of gastric mucosa and the atrophy of gastric mucosa glands. Especially, better effects were shown in the mid and high dose groups.

CONCLUSIONMica has the pharmacological action of protecting the gastric mucosa, enhancing blood flow of the gastric mucosa, and consequently improving the inflammatory responses of the gastric mucosa. One of the mechanisms is associated with promoting the secretion of gastric acid and gastric pepsin and regulating the neuroendocrine mechanism including gut hormone secretion (gastrin and somatostatin) by increasing the number of chief and parietal cells as well as G and D cells.

Aluminum Silicates ; pharmacology ; Animals ; Cell Count ; Chief Cells, Gastric ; drug effects ; pathology ; Chronic Disease ; Gastric Mucosa ; drug effects ; pathology ; Gastrin-Secreting Cells ; drug effects ; pathology ; Gastritis, Atrophic ; pathology ; Inflammation ; Parietal Cells, Gastric ; drug effects ; pathology ; Powders ; Rats ; Rats, Sprague-Dawley ; Somatostatin-Secreting Cells ; drug effects ; pathology

The purpose of this study was to examine the ultrastructural characteristic of the normal pylorus mucosa, and their structural changes induced by the ligation of common bile duct of the male rabbits weighing about 1.5 kg each. Experiment animals were divided into normal, sham operation, and experimental groups. Common bile duct ligation was performed under ether anesthesia and anjmals were sacrificed on the 1st, 3rd, 5th, 7th and 14th day after operation. The mucosal specimen of the pylorus, were fixed and embedded with common method. The sections were cut on a LKB-V ultratome, and observed under a JEM 100CX II electron microscope. The results were as follow : 1. In the early stages (1st, 3rd, 5th day groups) following the ligation, surface mucous cells have the various electron densities and shape of the mucous granules. In the late stages (7th, 14th day groups) following the ligation, many surface mucose cells containing numerous electron dense mucous granules are seen. 2. In the early stage of the ligation of bile duct, secretory function of EC cells was depressed, but in the later stage, the cells showed recovered secretory activity. 3. Secretory function of D cells was depressed on the early groups after the ligation of common bile duct, but they showed recovered secretory activity from the late groups after the ligation of the common bile duct. 4. Secretory function of G cells was activated on the early groups after the ligation of common bile duct, but they showed depressed secretory activity from the late groups after the ligation of the common bile duct. Considering the above findings, common bile duct ligation probably causes the dysfunction of the pyloric surface mucous cells that results in delayed mucous formation and secretion, and recovered mucous secretory function on the late stages. EC cells and G cells, depressed the secretory activities on the early stages and recovered on the late stages of the ligation of common bile duct. But D cells in the pyloric mucosa was activated on the early groups after the ligation of common bile duct ligation, but they was depressed secretory activities on the late groups.
Anesthesia ; Animals ; Bile Ducts ; Common Bile Duct* ; Ether ; Gastrin-Secreting Cells ; Humans ; Ligation* ; Male ; Mucous Membrane* ; Pylorus ; Rabbits ; Somatostatin-Secreting Cells

BACKGROUND: CD99 is characteristically expressed in Ewing's sarcoma/primitive neuroendocrine tumors and its immunoreactivity has also been reported in gastrointestinal neuroendocrine tumors. However, the normal distribution of CD99 reactive cells in gastrointestinal mucosa and their function are not fully understood. METHODS: We performed an immunohistochemical study using antibodies to CD99 and gastrin on formalin fixed and paraffin embedded tissue of the stomach. RESULTS: CD99 were strongly expressed in the gastric glands of neonate (3/3) and infant (1/1) cases but not detected in the fetal period (0/30). In adults, CD99 was observed in 36.8% (7/19). The number of CD99 positive cells were fewer in adult (3.48+/-6.43) than in neonate (5.66+/-0.58) and infant (11.33+/-2.21). CD99 was mostly located along the cytoplasmic membrane of glandular cells but cytoplasmic expression was also evident in neonate and infant cases. The G cells and CD99 expressed cells were reduced in the area showing intestinal metaplasia and atrophic change. As a result of the double stain, some of the G cells coexpress CD99 antigen, which were more in neonate (29%) than in adult (2.6%). CONCLUSIONS: The CD99 positive cells were found in the gastric pyloric antrum during the postnatal period and progressively reduced with age. This suggests the participation of CD99 protein in the differentiation and secretory process of neuroendocrine cells.
Adult ; Antibodies ; Cell Membrane ; Cytoplasm ; Formaldehyde ; Gastric Mucosa* ; Gastrin-Secreting Cells ; Gastrins ; Humans* ; Infant ; Infant, Newborn ; Metaplasia ; Mucous Membrane ; Neuroendocrine Cells ; Neuroendocrine Tumors ; Paraffin ; Pyloric Antrum ; Secretory Pathway ; Stomach

Heterotopic gastrointestinal cysts are rarely found in the oral cavity. Most of these cysts are lined with gastric mucosa and involve the tongue. There have been no reported heterotopic intestinal cysts of the submandibular gland that are completely lined with colonic mucosa. An 8-year-old girl presented with an enlarging swelling in the left submandibular area, and a 4-cm unilocular cyst was fully excised. The cyst was completely lined with colonic mucosa that was surrounded by smooth muscle layer, and the lining cells were positive for CDX-2, an intestinal marker, indicating a high degree of differentiation. The pathogenesis remains unclear, but it may be related to the misplacement of embryonic rests within the oral cavity during early fetal development. Although heterotopic intestinal cysts rarely occur in the submandibular gland, they should be considered in the differential diagnosis of facial swellings in the pediatric population.
Colon ; Diagnosis, Differential ; Fetal Development ; Gastric Mucosa ; Intestines ; Mouth ; Mucous Membrane ; Muscle, Smooth ; Submandibular Gland ; Tongue

No abstract available.
Eating* ; Gastric Mucosa* ; Hydrochloric Acid* ; Mucous Membrane*

An umbilical polyp is a rare congenital lesion and it represents one of the developmental anomalies of omphalomesenteric duct remnants. Clinically, an umbilical polyp presents as a red, firm and round tumor with mucoid and sometimes bloody secretions. Umbilical polyps can be mistaken clinically for other umbilical disorders such as umbilical granulomas and granuloma pyogenicum. Hisopathologically, the umbilical polyp is usually composed of small intestinal mucosa or ectopic gastrointestinal mucosa. Herein, we report on two cases of umbilical polyps:one umbilical polyp was composed of small intestinal mucosa and the other consisted of gastric mucosa.
Gastric Mucosa ; Granuloma ; Granuloma, Pyogenic ; Intestinal Mucosa ; Mucous Membrane ; Polyps ; Vitelline Duct

The Laugier-Hunziker syndrome represents a rare, acquired, benign, pigmentary disorder of the lips, oral mucosa, and nails. The nails are often involved with the development of melanonychia, which may be due to focal melanocyte activation. The lips and the mucous membranes show a variable number of flat, gray to brown-black lenticular spots, which are usually asymptomatic. We report the third case of Laugier-Hunziker syndrome in the Korean literatures.
Lip ; Melanocytes ; Mouth Mucosa ; Mucous Membrane

Pleomorphic adenoma is most frequently seen in the major salivary glands, but can also be found in oral mucosa, hard and soft palate, temporal bone, hypophyseal duct, limbs, skin, inguinal region as well as in the nasal cavity. The majority of intranasal pleomorphic adenomas originate from the mucosa of nasal septum and lateral nasal wall. The treatment of choice is local but adequate excision. The authors experienced a rare case of pleomorphic adenoma that arose from the nasal vestibule: it was treated with local excision. We report the case with a review of literatures.
Adenoma ; Adenoma, Pleomorphic* ; Extremities ; Mouth Mucosa ; Mucous Membrane ; Nasal Cavity ; Nasal Septum ; Nose ; Palate, Soft ; Salivary Glands ; Skin ; Temporal Bone

Retroperitoneal foregut duplication cyst is an extremely rare congenital malformation. Pathologically, this lesion contains both gastric mucosa and respiratory type mucosa; radiologically, it is often challenging to differentiate it from the other cystic neoplasms that present a similar appearance. We report here on a case of retroperitoneal foregut duplication cyst that was lined by both gastric and pseudostratified ciliated columnar epithelium, and it was also accompanied by a pancreatic pseudocyst. Initially, it presented with peripancreatic and intrapancreatic cystic masses in an asymptomatic 30-year-old man, and this man has since undergone surgical resection.
Adult ; Epithelium ; Gastric Mucosa ; Humans ; Mucous Membrane ; Pancreatic Pseudocyst

Gastric plasmacytomas are very rare, and most are not detected until the disease has progressed to an advanced stage. However, there have been recent reports of cases of early-stage gastric plasmacytoma, in which neoplastic cells are confined to the mucosa or submucosa. Here we report a case of a very early stage gastric plasmacytoma that was confined to the lamina propria of the gastric mucosa. The lesion was successfully and completely removed by endoscopic submucosal dissection, and the surveillance endoscopy showed no recurrence during the follow-up of 40 months. This report appears to be the first documented case of complete endoscopic removal of a primary gastric plasmacytoma.
Endoscopy ; Follow-Up Studies ; Gastric Mucosa ; Mucous Membrane ; Plasmacytoma ; Recurrence