Gastroesophageal reflux disease (GERD) is defined as a condition which develops when the reflux of gastric contents causes troublesome symptoms and long-term complications. GERD can be divided into erosive reflux disease and non-erosive reflux disease based on endoscopic findings defined by the presence of mucosal break. The Los Angeles classification excludes minimal changes as an evidence of reflux esophagitis because of poor interobserver agreement. In the Asian literature, minimal changes are considered as one of the endoscopic findings of reflux esophagitis, but the clinical significance is still controversial. Minimal change esophagitis is recognized quite frequently among patients with GERD and many endoscopists recognize such findings in their clinical practice. This review is intended to clarify the definition of minimal change esophagitis and their histology, interobserver agreement, and symptom association with GERD.
Esophagitis/pathology ; Esophagoscopy ; Gastroesophageal Reflux/classification/*diagnosis ; Humans ; Mucous Membrane/pathology

Bladder interstitial cell (IC) is a cell, which lacks thick filaments and dense bodies but with incomplete basement membrane, rough endoplasmic reticulum and golgi apparatus. IC is divided into 4 subtypes: lamina propria IC, intramuscular IC, IC between the detrusor bundles and perivascular IC. There are different ion currents and related activation pathways in the lamina propria IC and intramuscular IC. Ca2+ signaling pathways play an important role in the communication between IC and detrusor. Any bladder lesions affecting the ion current and Ca2+ signaling pathways can lead to bladder dysfunction. The bladder lesions include bladder outlet obstruction, bladder pain syndrome, interstitial cystitis, neurogenic bladder and diabetes. Imatinib mesylate is currently an available treatment target in IC, and electrical stimulation of acupuncture therapy is a new direction.
Benzamides ; Cystitis, Interstitial ; pathology ; Electric Stimulation ; Humans ; Imatinib Mesylate ; Mucous Membrane ; pathology ; Piperazines ; Pyrimidines ; Signal Transduction

OBJECTIVETo compare the difference of mucosal damage in the remnant esophagus with similar postoperative reflux after esophagectomy and gastric interposition between Chinese and Canadian population.

METHODSA prospective 1 to 1 paired study based on the same surgical approach was performed in Medical Centre of University of Montreal and West China Hospital of Sichuan University during the period from September 2010 to October 2013. The patients were followed up and evaluated by reflux symptom scoring, endoscopic assessment of mucosal damage, pathologic examination of biopsies and proliferation index test of esophageal epithelium.

RESULTSEighteen Han Chinese and 18 Caucasian Canadian patients with esophagectomy and gastric interposition were included in this study, with a follow-up period of 45 (28-67) months. There were no significant differences between the two groups in the incidence of postoperative reflux symptom, reflux symptom scoring, histological reflux esophagitis, erosion or stricture of remnant esophagus (all P>0.05). However, the incidence of mucosal metaplasia [44.4% (8/18) versus 11.1% (2/18), P=0.026], quantitative MUSE scoring [1.5 (1.0-2.0) versus 1.0 (0-2.0), P=0.042] and proliferation index [0.40 (0.30-0.45) versus 0.35 (0.30-0.50), P=0.038] of esophageal epithelium were significantly higher in Canadian patients than those in Chinese patients.

CONCLUSIONUnder similar reflux situation, esophageal mucosa of Canadian population is more sensitive to the gastroesophageal reflux damage compared with Chinese population, resulting in more severe reflux damage of remnant esophagus in Canadian patients.

Biopsy ; Canada ; China ; Esophagectomy ; adverse effects ; Gastroesophageal Reflux ; pathology ; Humans ; Metaplasia ; Mucous Membrane ; pathology ; Prospective Studies

The present paper was aimed to study the security of burning during the continuous monitoring of transesophageal arterial oxygen saturation. 20 rabbits were randomly divided into two groups: control group and high-frequency electrotome group. All rabbits were implanted with the oxygen saturation detection probes into the lower esophageal after anesthesia. The probes were made up with two light-emitting diode (LED) and then connected with oxygen saturation sensor to monitoring for 2h and 6h, respectively. We then intercepted two luminous points as esophageal specimens and dist the esophageal tissue detection device headend 1cm gastric side esophageal specimens (self-contr01) after monitoring, and carried out pathological examination. The pathological results of the LED-1, LED-2 esophageal biopsy and self-control section were mucous integrity, submucosal mildedema, hyperemia, a small number of lymphocytes and mononuclear cell infiltration. All the score of the esophageal tissue histologic was 2. The results showed that montioring the SteO2 not more than 6h was safe with montiored using a matching of oxygen saturation sensor and monitoring esophageal arterial oxygen saturation.
Animals ; Esophagus ; pathology ; Female ; Male ; Mucous Membrane ; pathology ; Oximetry ; adverse effects ; methods ; Rabbits ; Safety

No abstract available.
Aged ; Biopsy ; Esophageal Neoplasms/*diagnosis/pathology ; Esophagoscopy ; Esophagus/*pathology ; Humans ; Male ; Mucous Membrane/pathology ; Papilloma/*diagnosis/pathology

Biopsy ; methods ; Esophageal Neoplasms ; pathology ; surgery ; Esophagoscopy ; Esophagus ; pathology ; Humans ; Mucous Membrane ; pathology ; Precancerous Conditions ; pathology ; surgery

OBJECTIVETo investigate the pathological changes of chronic intermittent hypoxia on upper and lower respiratory tissue in experimental rats.

METHODSA total of 40 female SD rats were divided into 2 groups. Twenty rats were fed in normal state (control group), and 20 rats were fed in hypoxia environment (hypoxia group). The pathological changes of upper and lower respiratory tissue were observed under optical microscope.

RESULTSChronic intermittent hypoxia resulted in irreversible changes both at upper and lower respiratory tract in rats. The thickness of the lamina propria in soft palate was significantly increased in hypoxia group (125.85 ± 6.34) µm vs. (57.26 ± 4.67) µm (t=36.330, P<0.01). Lung pathological examination in hypoxia group showed pulmonary interval thickening (2.15 ± 0.49) µm vs. (0.45 ± 0.12) µm (t=14.132, P<0.01).

CONCLUSIONSThis study confirmed that long-term hypoxia can lead to organization reconstruction in upper and lower respiratory tract in rats. In OSAHS patients, it is suggested that earlier intervention could alliviate the pathological changes in respiratory system.

Animals ; Female ; Hypoxia ; pathology ; Lung ; pathology ; Mucous Membrane ; pathology ; Palate ; pathology ; Rats ; Rats, Sprague-Dawley ; Sleep Apnea, Obstructive

We report two cases of mucinous ductal ectasia of the pancreas which showed characteristic pancreatoscopic findings. They also showed characteristic duodenoscopic findings such as patulous ampullary orifice and mucus leakage from the papilla, and underlying pathology was hyperplasia in one case and adenoma in the other case, The insertions of pancreatoscope into the main pancreatic duct were easy without previous sphincterotomy and whitish frog egg-like mucosa was noted in one case and finger-like papillary projection was noted in the other case.
Adenoma ; Dilatation, Pathologic* ; Hyperplasia ; Mucins* ; Mucous Membrane ; Mucus ; Pancreas* ; Pancreatic Ducts ; Pathology

BACKGROUND: Inter-observer and intra-observer variation in histologic tumor grading are well documented. To determine whether histologic disorderliness in the arrangement of tumor cells may serve as an objective criterion for grading, we tested the hypothesis the degree of disorderliness is related to the degree of tumor differentiation on which tumor grading is primarily based. METHODS: Borrowing from the statistical thermodynamic definition of entropy, we defined a novel mathematical formula to compute the relative degree of histologic disorderliness of tumor cells. We then analyzed a total of 51 photomicrographs of normal colorectal mucosa and colorectal adenocarcinoma with varying degrees of differentiation using our formula. RESULTS: A one-way analysis of variance followed by post hoc pairwise comparisons using Bonferroni correction indicated that the mean disorderliness score was the lowest for the normal colorectal mucosa and increased with decreasing tumor differentiation. CONCLUSIONS: Disorderliness, a pathologic feature of malignant tumors that originate from highly organized structures is useful as an objective tumor grading proxy in the field of digital pathology.
Adenocarcinoma ; Colonic Neoplasms ; Entropy ; Humans ; Mucous Membrane ; Neoplasm Grading ; Observer Variation ; Pathology ; Proxy ; Thermodynamics

BACKGROUND/AIMS: The role of Helicobacter pylori in bile reflux gastritis (BRG) is uncertain. We show the role of H. pylori and pathology in BRG. METHODS: Thirty seven patients, including 5 patients who had undergone subtotal gastrectomy, were diagnosed with BRG by gastroscopic findings of bile-stained mucosa with hyperemia/ erosions. We measured total bile acid (TBA) concentration and compared the H. pylori positivity between BRG patients and 70 non-BRG patients. We showed how often we could see the pathologic findings of reactive gastritis in BRG and compared the grade of lymphoplasma cell and neutrophil infiltration between H. pylori positive and negative group in BRG. RESULTS: TBA concentration of 10 patients was 7,376.7+/-5,482.6micro mol/L. H. pylori positive rate of BRG was 45.9% and that of non-BRG was 70% (p=0.015). The gastric pit elongation and tortuosity were found only in 3 cases with gastric surgery. The grade of lymphoplasma cell and neutrophil infiltration was 2.41+/-0.51 and 1.88+/-0.86 in H. pylori positive BRG and 1.55+/-0.69 and 0.55+/-0.76 in H. pylori negative BRG, respectively (p<0.001). CONCLUSIONS: H. pylori infection in BRG was lower than that in non-BRG. The gastric pit elongation and tortuosity of BRG were not seen often. The lymphoplasma cell and neutrophil infiltration were relatively sparse in H. pylori negative BRG.
Bile Reflux* ; Bile* ; Duodenogastric Reflux ; Gastrectomy ; Gastritis* ; Helicobacter pylori* ; Helicobacter* ; Humans ; Mucous Membrane ; Neutrophil Infiltration ; Pathology