2.A Case of Duodenal Mucormycosis in a Immunocompetent Patient.
Seo Ryoung HAN ; Hee Seung PARK ; Seong Ho CHOI ; Tae Hun KWON ; Mu Young KIM ; Woo Seok KIM ; Hye Jin LEE ; Joong Gil LEE
Korean Journal of Gastrointestinal Endoscopy 2000;20(4):303-306
Mucormycosis is a rare and fulminating opportunistic fungal infection that occurs almost in immunocom-promised patients. It is also a highly virulent and rapidly progressive disease with poor prognosis. Its incidence has been increasing in recent years. We have experienced a case of solitary duodenal mucormycosis in a 45 year-old male patient. Mucormycosis was diagnosed by pathology & culture and he was treated with amphotericin B and discharged with clinical improvement. We report this case with a literature review.
Amphotericin B
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Mucormycosis*
;
Pathology
;
Prognosis
3.Two Cases of Rhinocerebral Mucormycosis with Perineural Extension to the Pons.
Yong Soo SHIM ; Joung Ho RHA ; Jee Hyun KWON ; Choong Kun HA
Journal of the Korean Neurological Association 1999;17(6):895-900
Rhinocerebral mucormycosis is a very rare, but mostly fatal fungal infection, usually found in diabetic or other immunocompromised hosts. It has a characteristic pattern of spread, invasion of vessel walls with subsequent local thrombotic infarction or direct invasion. But we found two cases contrast to these typical patterns of spread. Our cases initially originated in the nasal cavity and progressed to the cavernous sinus in usual manner, but after then, extended along the trigeminal nerve into the pons. MRI demonstrated the perineural spread, which was confirmed by pathology.
Cavernous Sinus
;
Immunocompromised Host
;
Infarction
;
Magnetic Resonance Imaging
;
Mucormycosis*
;
Nasal Cavity
;
Pathology
;
Pons*
;
Trigeminal Nerve
4.Two Cases of Rhinocerebral Mucormycosis with Perineural Extension to the Pons.
Yong Soo SHIM ; Joung Ho RHA ; Jee Hyun KWON ; Choong Kun HA
Journal of the Korean Neurological Association 1999;17(6):895-900
Rhinocerebral mucormycosis is a very rare, but mostly fatal fungal infection, usually found in diabetic or other immunocompromised hosts. It has a characteristic pattern of spread, invasion of vessel walls with subsequent local thrombotic infarction or direct invasion. But we found two cases contrast to these typical patterns of spread. Our cases initially originated in the nasal cavity and progressed to the cavernous sinus in usual manner, but after then, extended along the trigeminal nerve into the pons. MRI demonstrated the perineural spread, which was confirmed by pathology.
Cavernous Sinus
;
Immunocompromised Host
;
Infarction
;
Magnetic Resonance Imaging
;
Mucormycosis*
;
Nasal Cavity
;
Pathology
;
Pons*
;
Trigeminal Nerve
5.Hepatic and small bowel mucormycosis after chemotherapy in a patient with acute lymphocytic leukemia.
Ill Woo SUH ; Chul Sung PARK ; Mi Suk LEE ; Je Hwan LEE ; Mee Soo CHANG ; Jun Hee WOO ; In Chul LEE ; Ji So RYU
Journal of Korean Medical Science 2000;15(3):351-354
Mucormycosis is a rare but invasive opportunistic fungal infection with increased frequency during chemotherapy-induced neutropenia. The clinical infections due to Mucor include rhinocerebral, pulmonary, cutaneous, gastrointestinal and disseminated diseases. The first two are the most common diseases and all entities are associated with a high mortality rate. Still hepatic involvement of Mucor is rarely reported. We experienced a case of hepatic and small bowel mucormycosis in a 56-year-old woman after induction chemotherapy for B-cell acute lymphocytic leukemia. Initial symptoms were a high fever unresponsive to broad spectrum antibiotics and pain in the left lower abdominal quadrant. It was followed by septic shock, deterioration of icterus and progressively elevated transaminase. An abdominal CT demonstrated multiple hypodense lesions with distinct margins in both lobes of liver and pericolic infiltration at small bowel and ascending colon. Diagnosis was confirmed by biopsy of the liver. The histopathology of the liver showed hyphae with the right-angle branching, typical of mucormycosis. The patient was managed with amphotericin B and operative correction of the perforated part of the small bowel was performed. However, the patient expired due to progressive hepatic failure despite corrective surgery and long-term amphotericin B therapy.
Case Report
;
Female
;
Human
;
Intestinal Diseases/therapy
;
Intestinal Diseases/radiography
;
Intestinal Diseases/pathology*
;
Intestinal Diseases/microbiology
;
Intestine, Small/radiography
;
Intestine, Small/pathology
;
Liver Diseases/therapy
;
Liver Diseases/radiography
;
Liver Diseases/pathology*
;
Liver Diseases/microbiology
;
Middle Age
;
Mucormycosis/therapy
;
Mucormycosis/radiography
;
Mucormycosis/pathology*
;
Mucormycosis/microbiology
;
Tomography Scanners, X-Ray Computed
6.Chronic mucor invasive fungal sinusitis with intraorbital extension: a case report.
Zhao-wei GU ; Zhi-wei CAO ; Xin-jia ZHOU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2009;44(1):76-77
Aged, 80 and over
;
Chronic Disease
;
Female
;
Humans
;
Mucor
;
pathogenicity
;
Mucormycosis
;
microbiology
;
pathology
;
Orbit
;
pathology
;
Sinusitis
;
microbiology
;
pathology
8.Rhinocerebral mucormycosis: report of two cases.
Chun-yan HE ; Yu-lan JIN ; Hong-gang LIU
Chinese Journal of Pathology 2010;39(5):345-346
Adolescent
;
Aged
;
Aspergillosis
;
microbiology
;
pathology
;
Aspergillus
;
isolation & purification
;
Brain Diseases
;
drug therapy
;
microbiology
;
pathology
;
surgery
;
Diabetes Complications
;
microbiology
;
Diagnosis, Differential
;
Female
;
Humans
;
Male
;
Mucorales
;
isolation & purification
;
Mucormycosis
;
drug therapy
;
pathology
;
surgery
;
Nose Diseases
;
drug therapy
;
microbiology
;
pathology
;
surgery
9.Two Cases of Disseminated Mucormycosis in Patients following Allogeneic Bone Marrow Transplantation.
Dong Gun LEE ; Jung Hyun CHOI ; Su Mi CHOI ; Jin Hong YOO ; Yoo Jin KIM ; Chang Ki MIN ; Seok LEE ; Dong Wook KIM ; Wan Shik SHIN ; Chun Choo KIM
Journal of Korean Medical Science 2002;17(3):403-406
We describe two cases of disseminated mucormycosis following allogeneic bone marrow transplantation (BMT). Both patients were suffering from chronic graft-ver-sus-host disease (GVHD) and treated with prolonged administration of corticosteroid. In both cases, the initial symptoms were high fever and left flank pain. Involved organs were the spleen, right kidney and the right lung in one case, and the spleen and the brain in the other. The diagnosis was confirmed by pathology after splenectomy. One patient, in whom the immunosuppressesants could be discontinued, was treated with prolonged conventional and liposomal amphotericin B and 5-fluorocytosine. The other, in whom the immunosuppressants could not be discontinued due to extensive GVHD, was unresponsive to amphotericin B, and eventually died from the fungal infection. Although mucormycosis, especially the disseminated form thereof is infrequent, it should be considered in high-risk patients because early diagnosis and timely therapy combining antifungal drug or surgery and reduction of immunosuppression appear to improve the prognosis.
Adult
;
Amphotericin B/administration & dosage
;
Antifungal Agents/administration & dosage
;
*Bone Marrow Transplantation
;
Fatal Outcome
;
Humans
;
*Immunocompromised Host
;
Immunosuppressive Agents/administration & dosage
;
Male
;
Mucormycosis/drug therapy/immunology/*pathology
;
Transplantation, Homologous
10.Ileal Mucormycosis Diagnosed by Colonoscopy in a Patient with Acute Myeloid Leukemia.
Jae Yong HAN ; Jae Hee CHEON ; Duk Hwan KIM ; Hong Jae CHON ; Sang Kyum KIM ; Tae Il KIM ; Yoo Hong MIN ; Won Ho KIM
The Korean Journal of Gastroenterology 2008;52(3):179-182
Gastrointestinal mucormycosis is an uncommon opportunistic fungal infection often presents in immunocompromised patients. Direct invasion of the intestinal walls by spores from ingested food is the main pathogenetic mechanism of this disease, which usually takes place in stomach and colon. Early diagnosis is critical, especially in vascular invasive types, due to its high mortality rate close to 100%. In the past when appropriate diagnostic tools were not available, mucormycosis were frequently found with autopsy. The advance in current endoscopic technology has increased diagnostic rate and made successful management available with appropriate treatments such as debridement of contaminated tissues. In this case report, we discussed a case of ileal mucormycosis diagnosed by colonoscopy and treated with anti-fungal agent successfully.
Amphotericin B/therapeutic use
;
Antifungal Agents/therapeutic use
;
Colonoscopy
;
Humans
;
Ileal Diseases/*diagnosis/microbiology/therapy
;
Ileum/pathology
;
Immunocompromised Host
;
Leukemia, Myeloid, Acute/*complications/drug therapy
;
Male
;
Mucormycosis/*diagnosis/etiology/therapy
;
Tomography, X-Ray Computed
;
Young Adult