1.Epidemiological and clinical characteristics of Kawasaki disease in children
Van Hai Dang ; Tra Nam Le ; Ha Sy Ho
Journal of Medical Research 2007;55(6):26-33
Background:Kawasaki is acute fever disease with systematic vein infection which often seen in children under 5 years old. Objectives:Describe the clinical characteristics and laboratory, echocardiography data in children with Kawasaki between early diagnosed group and late one. Subjects and method: A descriptive, prospective study was carried out on 77 Kawasaki disease patients were selected, including 50 patients were diagnosed before day 10 of illness (group 1) and 27 patients were diagnosed on or after day 10 (group 2) in the National Pediatrics hospital from June 2004 to June 2006. Results:The mean was 13.4 months. Age under 12 months was 61 %. Male/female ratio was 1.7: 1. Fever, red lips, red eyes, skin rash, extremities edema and cervical lymphadenopathy occurred in the first week. The inflammatory response was strong (CRP: 83.6 mg/I, erythrocyte sedimentation rate (ESR) after an hour: 79.1 mm. WBC: 27800/ mm3). There were no differences between patients in the group 1 and group 2 in age, gender, time to the first medical visit, C-reactive protein (CRP) concentration, white blood cell count or erythrocyte sedimentation rate. Patients in the group 1 had significantly close clustering of symptoms onset in the first few days of illness, but patients in the group 2 had onset of symptoms scattered over 4 days. A platelet count of over 500.000/mm3 occurred more often in the group 2 (60%) than the group 1 (31.3%). Coronary involvement was observed in 23 patients (29.8%) including 17 patients who had coronary dilation and 6 patients with coronary aneurysm. Conclusion:Coronary artery abnormalities in the group 2 (48.1%) occurred significantly more than the group 1 (20%).
Mucocutaneous Lymph Node Syndrome/ diagnosis
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pathology
;
Child
2.Coronary lesion in Kawasaki disease in children
Van Hai Dang ; Tra Nam Le ; Ha Sy Ho
Journal of Medical Research 2007;55(6):13-20
Background: Kawasaki is an acute fever disease with systematic vein infection and often seen in children.Objectives:This study aims to determine features and risk factors of coronary artery lesion (CAL) in Kawasaki disease in children. Subjects and method:A descriptive, prospective study was conducted on 83 patients diagnosed with Kawasaki disease whom treated at National Hospital for Pediatric from January 2005 to March 2007. They were divided into 2 groups: with and without CAL. All data from clinical characteristics, laboratory and echocardiography were analyzed to evaluate the differences between 2 groups. Univariate and multivariate analysis were used. Results: Among 83 patients diagnosed with Kawasaki disease, 27 patients (32.5%) was found with CAL. 24 patients (88.9%) had both right and left coronary artery abnormalities. The CAL in left anterior descending (LAD) and in left circumflex coronary artery (LCX) was 55.6% and 25.9% respectively. Risk level II: 7 patients (25.9%). Risk level III: 14 patients (51.9%) and risk level IV: 6 patients (22.2%). 14 patients (51.9%) with CAL were resolved at 6th month of the illness. Independent risk factors of CAL in acute stage included age under 12 months (OR = 3.97, p<0.05). IVIG treatment was within the first 10 day of the illness (OR=0.25, p<0.05). Non - responsiveness to \u03b3globulin therapy (OR=7.69, p<0.01). CRP before starting initial treatment above 90mg/1 (OR = 12.81, p<0.05). Platelets before starting \u03b3 globulin therapy ~ 557 000/ mm3 with OR=4.73 and p<0.05. Conclusion:Early detection and treatment were necessary in order to decrease CAL in patients with Kawasaki disease.
Mucocutaneous Lymph Node Syndrome/ diagnosis
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pathology
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Coronary Vessels/ pathology
;
Child
3.Kawasaki Disease Mimicking Retropharyngeal Abscess.
Ramaswamy GANESH ; Vazhkudai Sridharan SRIVIDHYA ; Thiruvengadam VASANTHI ; Somu SHIVBALAN
Yonsei Medical Journal 2010;51(5):784-786
Kawasaki disease is an acute, self-limiting febrile mucocutaneous vasculitis of infants and young children. Retropharyngeal lymphadenopathy is a rare presentation of Kawasaki disease. We present a case of Kawasaki disease mimicking a retropharyngeal abscess, with upper airway obstruction resulting in delayed diagnosis.
Child
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Humans
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Male
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Mucocutaneous Lymph Node Syndrome/*diagnosis/*pathology
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Retropharyngeal Abscess/*pathology
6.Kawasaki disease complicated with mild encephalitis/encephalopathy with a reversible splenial lesion: A case report and literature review.
Yan Yan DU ; Jian WANG ; Lan HE ; Li Na JI ; Xi Wei XU
Journal of Peking University(Health Sciences) 2022;54(4):756-761
We reported a pediatric case of Kawasaki disease complicated with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) from Beijing Tsinghua Changgung Hospital. The clinical data were retrospectively analyzed and the related literature was reviewed. The clinical features, treatment and prognosis of the disease were summarized to improve recognition of Kawasaki disease complicated with MERS. A 7-year-old boy was diagnosed with Kawasaki disease due to continuous high fever for 6 d, accompanied by strawberry tongue, conjunctival congestion, erythema-like hyperemia rash, and cervical enlarged lymph nodes. And treatment was started with intravenous immunoglobulin (IVIG: 2 g/kg) and oral aspirin [40 mg/(kg·d)]. Twenty-four hours after the treatment of IVIG, the patient' s fever persisted and in addition he developed headache and drowsiness. His cranial magnetic resonance imaging (MRI) demonstrated a localized lesion in the splenium of the corpus callosum with high intensity signal on diffusion-weighted images (DWI) and T2-weighted, and low intensity signal on apparent diffusion coefficient (ADC) and T1-weighted. Based on these findings, he was diagnosed with MERS-complicated Kawasaki disease. Methylprednisolone [2 mg/(kg·d)] treatment was started intravenously, and within several hours he was afebrile and the neurological symptoms disappeared. A follow-up MRI was conducted after 1 week was normal. He was discharged without any neurological sequelae and coronary artery lesions. A total of 12 qualified foreign literature were retrieved, with no Chinese literature searched. Seventeen children were reported, the median age was 6.5 years (range: 1-14 years), among them 11 cases were children over 5 years old, and 4 cases were complicated with coronary artery lesions. All children had neurological symptoms, such as consciousness disorder, visual hallucination or convulsion. MRI conformed to MERS imaging changes. After active treatment, the neurological manifestations and radiological abnormalities completely disappeared, leaving no neurological sequelae. Kawasaki disease complicated with MERS had not been reported in China by now. Literature that identified Kawasaki disease complicated with MERS mostly occurred in children over 5 years old. Cranial MRI examination is helpful for early diagnosis. Timely treatment can reverse MERS in a short time, without neurological sequelae left.
Brain Diseases/diagnosis*
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Child
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Child, Preschool
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Encephalitis/pathology*
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Fever
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Humans
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Hyperplasia/complications*
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Immunoglobulins, Intravenous/therapeutic use*
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Magnetic Resonance Imaging
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Male
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Mucocutaneous Lymph Node Syndrome/diagnosis*
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Retrospective Studies
7.Pathologic diagnosis and classification of vasculitis.
Chinese Journal of Pathology 2006;35(3):179-182
Churg-Strauss Syndrome
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pathology
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Diagnosis, Differential
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Giant Cell Arteritis
;
pathology
;
Granulomatosis with Polyangiitis
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pathology
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Humans
;
Mucocutaneous Lymph Node Syndrome
;
pathology
;
Polyarteritis Nodosa
;
pathology
;
Purpura, Schoenlein-Henoch
;
pathology
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Takayasu Arteritis
;
pathology
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Thromboangiitis Obliterans
;
pathology
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Vasculitis
;
classification
;
pathology
8.Recurrent Kawasaki disease presenting as acute airway obstruction.
Xinyin Anna SEE ; Vijay PRAKASH ; Kun Kiaang Henry TAN
Singapore medical journal 2012;53(12):e264-6
Kawasaki disease is a common paediatric vasculitide. It is usually diagnosed by its classical constellation of mucocutaneous signs. Recurrent Kawasaki disease is a rare phenomenon that occurs in approximately 3% of all patients diagnosed with Kawasaki disease. Its presentation is usually similar to the first episode of Kawasaki disease, and early diagnosis with prompt treatment is key in preventing associated cardiovascular morbidities. Recurrent Kawasaki disease is not well reported, and atypical presentations have not been previously reported in medical literature. Here, we report the case of a young girl with recurrent Kawasaki disease who presented atypically with acute airway obstruction secondary to retropharyngeal phlegmon.
Acute Disease
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Airway Obstruction
;
diagnosis
;
etiology
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Child, Preschool
;
Diagnosis, Differential
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Female
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Humans
;
Lymph Nodes
;
diagnostic imaging
;
pathology
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Mucocutaneous Lymph Node Syndrome
;
complications
;
diagnosis
;
Neck
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Recurrence
;
Tomography, X-Ray Computed
9.Clinical value of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 for the prediction and early diagnosis of coronary artery lesion in patients with Kawasaki disease.
Qian PENG ; Tong-fu ZHOU ; Chang-hui CHEN ; Yi-min HUA ; Han-min LIU ; Hua HONG ; Ling-ying ZHANG ; Qing WU
Chinese Journal of Pediatrics 2005;43(9):676-680
OBJECTIVEKawasaki disease (KD) complicated with coronary artery lesion (CAL) seriously threatens survival quality and life of patients, suggesting that it is very important to early predict the risk of CAL and to early diagnose the disease. Nevertheless, up to now there has been no specific clinical biochemical marker for it because of the poor understanding of the pathological process of KD with CAL. Matrix metalloproteinases (MMPs) and their specific tissue inhibitor of metalloproteinases (TIMPs) play an important role in arterial wall extracellular matrix breakdown and remodeling and are involved in CAL in other diseases. In the present study the practical value of serum MMP-9 and TIMP-1 levels in the prediction and early diagnosis of CAL in KD patients was investigated.
METHODSAll subjects were from Chinese population. Serum levels of MMP-9 and TIMP-1 were measured by rapid one-step sandwich enzyme immunoassay in 59 KD patients including 15 with CAL and 44 without CAL by 2 D-echocardiography and coronary angiography, and 20 normal healthy children as controls. Blood samples of patients were obtained before and after intravenous immunoglobulin (IVIG) treatment in acute stage, subacute stage and convalescent stage as well. Serum MMP-9 and TIMP-1 levels and the ratio of MMP-9/TIMP-1 were compared by statistical method in KD patients and controls, as well as in KD with CAL and without CAL.
RESULTSIn acute stage serum MMP-9 and TIMP-1 levels and the ratio of MMP-9/TIMP-1 were higher (P < 0.01) in patients with KD than those in healthy children. After IVIG treatment in KD patients serum MMP-9 level and the ratio of MMP-9/TIMP-1 decreased (P < 0.01). Before IVIG treatment serum MMP-9 level and the ratio of MMP-9/TIMP-1 were higher (P < 0.01) in patients with CAL than those in patients without CAL, and in acute stage after IVIG treatment serum MMP-9 level of KD patients with CAL was still higher than that of KD patients without CAL.
CONCLUSIONIn acute stage of KD serum MMP-9 level and the ratio of MMP-9/TIMP-1 were higher in patients with CAL than those in patients without CAL, suggesting that during acute phase of KD the great increase in serum MMP-9 and the imbalance of the MMP-9/TIMP-1 ratio might be high risk factors of KD coronary artery lesion. Therefore, the measurement of serum MMP-9 and TIMP-1 might be of important clinical value in the prediction and the early diagnosis of KD with coronary artery lesion.
Biomarkers ; blood ; Case-Control Studies ; Child ; Child, Preschool ; Coronary Artery Disease ; blood ; complications ; diagnosis ; pathology ; Female ; Humans ; Infant ; Male ; Matrix Metalloproteinase 9 ; blood ; Mucocutaneous Lymph Node Syndrome ; blood ; complications ; Tissue Inhibitor of Metalloproteinase-1 ; blood
10.A case with neonatal Kawasaki disease.
Chinese Journal of Pediatrics 2003;41(12):960-960
Anti-Inflammatory Agents, Non-Steroidal
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therapeutic use
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Aspirin
;
therapeutic use
;
Coronary Vessels
;
pathology
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Echocardiography, Doppler, Color
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Electrocardiography
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Erythema
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Fever
;
Humans
;
Hypoxia-Ischemia, Brain
;
complications
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Infant, Newborn
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Male
;
Mucocutaneous Lymph Node Syndrome
;
complications
;
diagnosis
;
therapy