1.Production of Chemokines in Kawasaki Disease, Henoch-Schonlein Purpura and Acute Febrile Illness.
Hyo Seok CHUNG ; Hyo Young KIM ; Hee Sun KIM ; Hee Jung LEE ; Ji Hyun YUH ; Eun Sil LEE ; Kwang Hae CHOI ; Young Hwan LEE
Journal of Korean Medical Science 2004;19(6):800-804
We compared the production of three chemokines; interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schonlein purpura (n=15) and acute febrile illnesses (n=12). The production of the chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly elevated in Kawasaki disease (538.6 +/-336.4 pg/mL) and acute febrile illnesses (417.1 +/-262.2 pg/mL) compared with in Henoch-Schonlein purpura (58.7 +/-95.7 pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with in Henoch-Schonlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro- levels were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schonlein purpura (29.4 +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an important role in Kawasaki disease. In acute febrile illness-es, both monocytes and neutrophils may play an important role. By contrast, Henoch-Schonlein purpura may not be associated with the role of monocytes and neutrophils. Further studies using a larger number of cases are needed.
Acute Disease
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Adolescent
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Chemokines/*blood
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Child
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Child, Preschool
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Comparative Study
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Female
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Fever/*blood/*epidemiology
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Humans
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Infant, Newborn
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Korea/epidemiology
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Male
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Mucocutaneous Lymph Node Syndrome/*blood/*epidemiology
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Purpura, Schoenlein-Henoch/*blood/*epidemiology
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Research Support, Non-U.S. Gov't
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Risk Assessment/methods
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Risk Factors