We report the first published case of multiple eruptive myxoid dermatofibroma (MEMDF) in a male with chronic hepatitis B infection presenting with eruptive lesions showing marked deposits of dermal mucin. Alcian blue and immunohistochemistry confirmed the diagnosis of myxoid dermatofibroma. Further work-up showed asymptomatic chronic hepatitis B infection without cirrhosis.This case highlights an extremely rare histologic variant and the importance of screening for altered immunity in patients with eruptive dermatofibromas.

Human ; Female ; Middle Aged ; Histiocytoma, Benign Fibrous ; Mucins ; Alcian Blue ; Hepatitis B, Chronic ; Immunohistochemistry ; Muc1 Protein, Human ; Mucin-1 ; Liver Cirrhosis ; Exanthema