Serpin peptidose inhibitor clade E (SERPINE),a kind of serpin peptidase inhibitors,belongs to the SERPIN super family,which have important impact on various significant biochemical responses and physiological functions in vivo.Research shows that SERPINE is widely expressed in a variety of tissues and cells,such as smooth muscle,cardiac muscle,liver,kidney,bone,blood cells,bone marrow stem cells,tumor tissue and so on.This paper mainly introduced the regulating effects and research progress of SERPINE1 (PAI-1),SERPINE2 (PN-1) and SERPINE3 in cell signal transduction pathways.