PURPOSE: An isolated posterior malleolar fracture in the ankle is very rare. We treated eight cases of isolated posterior malleolar fracture, and describe the clinical features and outcomes of treatment. MATERIALS AND METHODS: Between from March 2008 to February 2012, eight cases of isolated posterior malleolar fracture were treated in Ilsan Paik Hospital. The mean age of patients was 30 years (11-49 years); six patients were male and five were right. Slip down (4 cases) was the most common injury mechanism. We treated four cases surgically, three cases by cast and one case by ankle brace. We could not recognize three cases of isolated posterior malleolar fracture at first. The time delay to diagnose unrecognized isolated posterior malleolar fracture was nine days, 56 days and 110 days respectively. We were able to diagnose the unrecognized isolated posterior malleolar fracture using computed tomography (two cases) and magnetic resonance imaging (one case). RESULTS: The main symptom was painful swelling. The average for articular involvement of the posterior malleolar fragment was average 21.4%, and average displacement was 1.25 mm. We treated three cases surgically using a posterior lateral approach and one case using a posterior medial approach. The average American Orthopaedic Foot and Ankle Society score was 92.5 at the last follow-up. CONCLUSION: The isolated posterior malleolar fracture is very rare and if it is neglected, persistent ankle pain can remain. Isolated posterior malleolus fracture should be included as one of the differential diagnoses after ankle trauma.
Ankle Fractures* ; Ankle* ; Braces ; Diagnosis, Differential ; Follow-Up Studies ; Foot ; Humans ; Magnetic Resonance Imaging ; Male

Tuberculosis of the salivary gland is a very rare disease and the incidence of the primary lesion more frequently involves the parotid gland than the submandibular or sublingual gland. Secondary tuberculosis may also occur but tends to occur in the submandibular or sublingual glands more frequently than in the parotid. It is associated with pulmonary tuberculosis and occurs in one of two forms-an acute inflammatory lesion or a chronic granulomatous lesion. In particular, the chronic granulomatous lesion presents a difficult diagnostic problem because it may mimic the more common tumorous lesion: usually, it is diagnosed after the excision biopsy. We have recently experienced a case of parotid tuberculosis that was diagnosed as the pleomorphic adenoma preoperatively, but which was confirmed as tuberculous lymphadenitis after superficial parotidectomy. We report it with a review of literature.
Adenoma, Pleomorphic ; Biopsy ; Incidence ; Parotid Gland ; Rare Diseases ; Salivary Glands ; Sublingual Gland ; Tuberculosis* ; Tuberculosis, Lymph Node ; Tuberculosis, Pulmonary

OBJECTIVE: Aquaporin (AQP) 3 is a small integral membrane protein that functions as a facilitated transporter of water and glycerol. To elucidate a role of AQP3 in placenta, changes in amniotic fluid composition and fetal growth were investigated using AQP3 null mice. METHODS: Embryonic day 14,5 gestational sacs of wild-type and AQP3 kncok-out pregnant mice, thirty each, were used for this study. AQP3 localization and expression were assessed by immunohistochemistry and western blot. RESULTS: AQP3 was highly expressed in basolateral membrane of visceral yolk sac cells of fetal membrane and syncytiotrophoblast cells of labyrinthine placenta. In contrast, AQP1 was expressed in apical membrane of visceral yolk sac cells and endothelial cells lining vasculature. There was no significant difference in normal placentation and differentiation from trophoblast stem cells between wild type and AQP3 null mice. However, AQP3 null mice had increased amount of amniotic fluid per gram of body weight and decreased osmorality of amniotic fluid with low concentrations of ions and solutes in amniotic fluid. In addition, AQP3 null mice pups were smaller than CD1 wild type mice. CONCLUSION: AQP3 plays an important role in amniotic water balance and nutrient supply to developing fetus by facilitating transplacental transport of water and glycerol.
Amniotic Fluid ; Animals ; Blotting, Western ; Body Weight ; Endothelial Cells ; Extraembryonic Membranes ; Female ; Fetal Development ; Fetus ; Gestational Sac ; Glycerol ; Immunohistochemistry ; Ions ; Membrane Proteins ; Membranes ; Mice ; Placenta ; Placentation ; Stem Cells ; Trophoblasts ; Water ; Yolk Sac