With specific physical characters,proton for postoperative breast cancer can improve dose homogeneity,lower dose to crucial organs such as the heart,lung and the opposite breast,and reduce the complications of normal tissues and incidence of the second primary tumor proton accelerated radiation for partial breast cancer can reduce therapy time,but its long time effect needs great patients and long time follow-up to beproved.

Hypoxia-inducible factor-1 (HIF-1) is a key transciptional regulator of cellular and systemic oxygen homeostasis,composed of the two subunits,HIF-1α and HIF-1β.HIF-1α is an inducible subunit regulated by hypoxia,which is posttranslationally modified by various ways,including ubiquitination,phosphorylation,hydroxylation,acetylation and glycation,accordingly affecting its protein's stability,nuclear translocation and regulation of its target genes.Small ubiquitin-related modifier (SUMO) is an micromolecule protein participating in posttranslational modifications of proteins dynamicly in eukaryotic organism,which is similar in structure to ubiquitin.SUMOylation and deSUMOylation are involved in multiple regulations of biologic processes,such as signal transduction,transcriptional regulation,cell cycle processes and biological rhythm.SUMOylation is related to HIF-1α stability and transcription activity in hypoxia,providing a newthread to study self-regulation mechanism of HIF-1α for us.

Radiotherapy is one of the main treatment options for patients with advanced limited non small cell lung cancer.From the viewpoint of radiobiology,the change of fractionation schedule in radiotherapy might improve the therapeutic effect.There are many different methods of fractionated irradiation: from conventional radiation including hyperfractionated radiotherapy,accelerated radiotherapy and hypofractionated radiotherapy,etc.In this paper,we summarized the definition of the different types of fractionated irradiation, and its clinical application.

Objective To investigate the prevention and treatment of the complications due to CT-guided percutaneous transthoracic biopsy. Methods CT-guided percutaneous transthoracic needle biopsy was performed in 168 patients aged from 14 to 79 years old. The complications and the contributing factors were analyzed. The methods for the prevention and treatment of the complicaitons were suggested. Results CT-guided percutaneous transthoracic needle biopsy was succeeded in 168 cases. The major complications associated with CT-guided needle biopsy included pneumothorax (8.33%) and pulmonary hemorrhage (20.24%). Pneumothorax was associated with the lesion size, lesion location, and times of puncture. Pulmonary hemorrhage was associated with the lesion size as well as the pre-operative evaluation of the vascular structures with contrast CT. Chest tube placement was performed in 1 out of 14 cases of pneumothorax. Other cases were not particularly treated. Conclusion The prevention of complications is important for CT-guided needle biopsy. The key factors to prevention the complications include accurate location of the lesions and correct evaluation of the vascular structures before the operation and skillful intraoperative puncture.

Objective To investigate the changes of ataxia-telangiectasia mutated(ATM)-Akt in the myocardium around the infarcted zones and its intervention by phenylephrine in rats.Methods Myocardial infarction(MI) and sham operation were established in Sprague Dawley male rats by Litwin's method.Three days after operation,surviving rats were divided into MI group(n=8),sham operation group(n=8),MI phenylephrine intervention group [n=8,phenylephrine 0.65 mg/(kg?d),i.p.,for 8 weeks),and sham operation phenylephrine intervention group(n=8,phenylephrine administered as above).Cardiac left ventricular posterior wall end-diastolic thickness(LVPWd),left ventricular end-diastolic diameter(LVDd),fractional shortening(FS) and ejection fraction(EF) were examined by Doppler ultrasonography.Twelve weeks after treatment,the expression of p-ATM substrate protein and p-Akt protein in the myocardium around the infarcted zones were detected by Western blot analysis and immunohistochemical assay respectively.Results In 12 weeks after treatment,LVDd(0.79?0.06) and(0.54?0.06) cm,FS(17.31?2.60)% and(38.58?2.56)%,and EF(67.75?3.54)% and(70.25?4.33)%(P0.05),and was(0.99?0.07) and(0.65?0.04) in MI phenylephrine intervention group and sham operation phenylephrine intervention group respectively(P0.05);and were(98.80?3.17) and(75.88?2.77) in MI phenylephrine intervention group and sham operation phenylephrine interventin group respectively(P

Objective To investigate the effect of nicardipine on the time-response relationships of vecuronium and atracuriumMethods Forty ASA grade Ⅰ-Ⅱ patients undergoing elective surgical operations were randomly allocated to four groups A single dose of vecuronium was intravenously administered at twice ED 95(01mg?kg -1) in groupⅠand combined with nicardipine 20?g?kg -1 in group Ⅱ Atracurium was given at the dose of twice ED 95 (05mg?kg -1) in groupⅢ and combined with nicardipine in group Ⅳ Anaesthesia was maintained with 50% nitrous oxide in oxygen and fentanyl in all groups Neuromuscular function was monitored with Biometer accelographResults The onset time of vecuronium was shortened from 26 min (groupⅠ) to 20 min (groupⅡ) (P

OBJECTIVETo investigate the influence of histological prostatitis (HP) on the clinical features of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) and its clinical significance.

METHODSWe retrospectively studied the data of 273 cases of BPH and 240 cases of PCa, including age, prostate volume, total prostatic special antigen (tPSA), prostatic special antigen density (PSAD), maximum urinary flow rate (MFR) and acute urinary retention (AUR).

RESULTSTotally, 186 cases of BPH (68.13%) and 45 cases of PCa (18.75%) were complicated by HP, with statistically significant difference between the two groups (P < 0.05). Compared with the patients with BPH only, those complicated by HP showed significantly elevated tPSA, PSAD and total prostate volume (all P < 0.05), decreased MFR (P < 0.05) and increased risk of AUR (P < 0.05). There was no significant difference in the patients' age between the two groups (P > 0.05). The levels of tPSA and PSAD were remarkably higher in the PCa patients complicated by HP than in those with PCa only (all P < 0.05), but no significant differences were found in the other indexes between the two groups (P > 0.05).

CONCLUSIONHP may play a certain role in the progenesis and progression of HP and PCa, but HP is associated more closely with BPH.

Aged ; Disease Progression ; Humans ; Male ; Organ Size ; Prostate ; pathology ; Prostate-Specific Antigen ; blood ; Prostatic Hyperplasia ; etiology ; Prostatic Neoplasms ; complications ; Prostatitis ; complications ; Retrospective Studies ; Urinary Retention ; etiology

Objective To explore the effects of repetitive transcranial magnetic stimulation (rTMS) and fluoxetine on depression and cognition in the treatment of post-stroke depression (PSD).Methods A total of 82 PSD patients were divided into a treatment group and a control group using a random number table.Besides conventional neurological therapy,the treatment group was treated with rTMS combined with fluoxetine,while the control group was treated only with fluoxetine.Forty healthy persons acted as normal controls.The Hamilton depression rating scale (HAMD) was used to evaluate depressed emotions,and event-related potential (ERP) P300 and exploratory eye movement (EEM) were used to evaluate cognitive function.The three groups were tested before treatment and after 8 weeks of treatment.Results After 8 weeks of treatment the HAMD scores in both the treatment and control groups had decreased significantly compared with before treatment.The HAMD scores decreased significantly more in the treatment group than in the control group.Before treatment,the N2 and P3 iatencies of P300 in the treatment and control groups were significant longer than those in the normal group,and the average amplitude of P3 in the treatment and control groups was significantly lower than among the normal controls.Before treatment,the number of eye fixations (NEF) and the average responsive search score (RSS) in the treatment group and control groups were significantly lower than in the normal group.After 8 weeks after treatment,the N2 and P3 latencies were significantly shorter and the amplitude of P3 was significantly higher in the treatment and control groups than before treatment.The NEF and the average RSS in the treatment and control groups had increased significantly compared with before treatment.All of these indexes improved significantly more in the treatment group than in the control group.Conclusion rTMS combined with fluoxetine can improve depression and cognitive function among PSD patients better than antidepressant treatment alone.

Objective To analyze the risk factors of respiratory failure after cervical spinal cord injury ( SCI) . Methods A total of 294 patients with cervical spinal cord injury from January 2009 and December 2013 were analyzed. 52 cases were rolled into the respiratory failure group, 242 cases were rolled into group without respiratory failure. The epidemiological factors in two groups were analyzed to find the the factors of respiratory failure. Results The differences in indexes of smoking, injury reason, injury level, grade of ASIA, fracture dislo-cation were significant (P<0. 05), which suggested the above factors were associated with the occurrence of respiratory failure. The multi-factor regression analysis in respiratory group found that factors such as aged over 60 years, smoking, multiple trauma, fracture dislocation, spinal cord injury above C4 level and pamplegia were of statistically significance (P<0. 10). Conclusion Advanced age, smoking, pample-gia, spinal cord injury above C4 leve, multiple trauma and fracture dislocation are the high risk factors of the respiratory failure after cervical spinal cord injury.