No abstract available.
Humans* ; Melanocytes* ; Tretinoin*

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign, uncommon disorder of unknown etiology, that usunlly appears as papules or nodules on the head and neck. Histopathologically, ALHE is a angioproliferating lesion which shows characteristically plump epithelioid or histiocytoid endothelial cells, accompanied by an inflammatory infiltrate that mainly consists of lymphocytes and eosinophils. We report a case of angiolymphoid hyperplasia with eosinophila associated with arteriovenous malformations in a 23-year-old man. In our patient, we observed arteriovenous malformation, changes which could have occurred by vascular repair due to a vascular malformation.
Angiolymphoid Hyperplasia with Eosinophilia ; Arteriovenous Malformations ; Endothelial Cells ; Eosinophils ; Head ; Humans ; Hyperplasia* ; Lymphocytes ; Neck ; Vascular Malformations ; Young Adult

BACKGROUND: The growth of cells is closely related to components in a culture medium. There are many reports about cellular characteristics of melanocytes grown in a PMA-contained medium. However, only a few reports have been studied by using a physiologic mitogens-contained medium. To understand melanocyte in vivo, it is necessary to know the cellular biology of melanocytes grown in a physiologic mitogens-contained medium. OBJECTIVE: To investigate any differences between melanocytes grown in phorbol 12-myristate 13-acetate(PMA)-contained medium and in physiologic mitogens-contained medium. METHOD: We examined morphology, number and melanin contents of cultured human melanocytes grown in a PMA-contained medium and physiologic mitogens-, such as bFGF, ET-1 and a a-MSH contained medium. Result : The results are summarized as follows : 1. There were no significant morphologic differences between cells in PMA-contained medium and in physiologic mitogens-contained medium. 2. The number of melanocytes were significantly more numerous in PMA-contained medium on the 2nd day (p<0.05), but significantly less numerous in the same medium on the 6th day (p<0.05). So, the proliferation rate of melanocytes in PMA-contained medium became lower than in physiologic mitogens-contained medium as time went by. 3. Melanocytes grown in PMA-contained medium had significantly increased melanin contents regardless of the time (p<0.05). Conclusion : The proliferation of melanocytes was better in physiologic mitogens-contained medium, the melanization was higher in melanocytes of PMA-contained medium.
Humans* ; Melanins ; Melanocytes*

Dowling-Degos disease, or reticular pigmented anomaly of the flexures, is a rare genodermatosis characterized by an acquired reticular macular hyperpigmentation that initially affects the axillae and groin and later involves intergluteal and inframammary folds, the neck, trunk, and arms. We report a case of Dowling-Degos disease occurring in a 40-year-old woman who has typical hyperpigmentation on flexural areas without any family history and has vesicles on the lip and oral mucosae.
Adult ; Arm ; Axilla ; Female ; Groin ; Humans ; Hyperpigmentation ; Lip ; Mouth Mucosa ; Neck

BACKGROUND: The visible cutaneous pigmentary response to ultraviolet A(UVA) is immediate, whereas ultraviolet B(UVB)-induced pigmentation appears after a delay of several days. However, some investigators reported that UVA also can induce delayed taniing. OBJECTIVE: In order to determine whether the pigmentation induceil by UVA irradiation is accompanied by melanocytes responses which are the same or different from those following a UVB-indueed tan, we irraiated malignant melanoma cells to UVA or UVB. METHOD: On the 7th day after irradiation of UVA or UVB, we exa nined the cell counts and the melanin content of control and experimental groups. RESULTS: Although a dose of 10 J/cm decreased the number of manignant melanoma cells, there was no significant difference between the control and UVA-exposure griiups. But there was a significant decrease after UVB-exposun. UVB-exposure groups showed a significant increase of melanin cortent. A dose of 10 J/cm of UVA also induced a significant increase of melanin content. CONCLUSIONS: The data suggest that UVA at a clinically relevant dose has a significant effect on human melanocytes. So, UVA very likely plays a role in the increased, melanization associated with delayed tanning.
Cell Count ; Cell Line* ; Humans ; Melanins ; Melanocytes ; Melanoma* ; Pigmentation ; Research Personnel ; Tanning ; Triacetoneamine-N-Oxyl

Periumbilical perforating pseudoxanthoma elasticum (PPPXE) is a localized acquired disorder found most frequently in obese, multiparous, middle-aged women. It is characterized clinically by yellowish, lax, well-circumscribed, reticulated or cobblestoned patches or plaques in the periumbilical region. Multiparity, obesity, massive ascites, and abdominal surgery are thought to the initiating factors. There is controversy about the etiology of PPPXE. Some authors have classified it as a separate entity from hereditary pseudoxanthoma elasticum (PXE), while others speculate that this condition merely represents a variable expression of PXE in which systemic associations are likely. We report a case of periumbilical perforating pseudoxanthoma elasticum associated with a clinical PXE lesion on the anterior neck.
Ascites ; Female ; Humans ; Neck ; Obesity ; Parity ; Pseudoxanthoma Elasticum*

BACKGROUND: Fixed drug eruptions(FDE) are a cutaneous reaction characterized by one or more circumscribed lesions that recur at the same site in response to a given medication. OBJECTIVE: The purpose of this study was to find the clinical and histopathological characteristics of FDE and to compare early FDE with late FDE histopathologically. METHOD: We clinically investigated 54 cases of FDE that visited the department of dermatology at the Kyunghee medical center from January 1993 to December 1996. Among them, 31 patients had skin biopsies and were evaluated histopathologically on the basis of duration. RESULTS: The results were summarized as follows: 1. Development of FDE did not show any difference according to sex and was evenly distributed over all the ages. 2. The latent periods of FDE were diverse in appearance from 30 minutes to 10 days, but mostly, the skin lesions erupted within 4S hours. 3. The most common skin lesions were erythematous macules. 4. Distribution of the lesions came out as solitary: 20.4%, multiple: 79.6%. S3.7% of the multiple lesions were localized to a part of body, and 16.3% were distributed over the whole body. 5. The areas in which the eruptions developed were (in descending order): upper extremity(37.0%), hand(31.5%), trunk(24.1%), face(24.1%). 6. In most cases(68.6%), the size and the number of lesions were greater in recurrente, rather than in first attacks. 7. The histopathological findings commonly showed perivascular mononuclear cell(MNC) infiltration (100%), pigmentary incontinence(77.4%), basal hydrophic degeneration(71.0%), eosinophil infiltration in dermis(61.3%), etc. 8. The epidermal histopathological findings such as spongiosis, exocytosis of MNC, basal hydrophic degeneration, keratinocyte necrosis and subepidermal vesicles could be seen more frequently in early lesions than in late ones. CONCLUSION: In our study, we were able to obtain meaningful results based on data from the combination of clinical and histopathological investigations. This study may give help to understand the characteristics of fixed drug eruptions and to plan future studies.
Biopsy ; Dermatology ; Drug Eruptions* ; Eosinophils ; Exocytosis ; Humans ; Keratinocytes ; Necrosis ; Skin

No abstract available.
Carcinoma, Adenoid Cystic*

The frequency of metastasis to the skin from lung cancer is 1-12%. The incidence of cutaneous metastasis was high in patients with large-cell lung cancer, whereas squamous cell and small-cell lung cancer showed the least tendency to extend to cutaneous sites. Adenocarcinoma was intermediate in the tendency to metastasize in the skin. Histological findings of small-cell lung cancer show solid, tumor cell nests composed of neoplastic cells with large, round nuclei. So, it is often difficult to distinguish small-cell lung cancer from other poorly differentiated small-cell tumors, such as Merkel cell carcinoma, metastatic carcinoid, lymphoma, etc. We report here two cases of skin metastasis from small-cell lung cancer. Case one was a 74-year-old man presenting with a single, round, dome-shaped nodule on the alar nasi which had been present for 1 month. The second case was a 73-year-old man who had found three, non-tender, freely movable subcutaneous nodules on the abdomen 3 days before. Both cases were diagnosed as small-cell lung cancer. On histopathological examination of the skin lesions, we could observe that small round to oval cells with dark staining nuclei and scant cytoplasms were arranged in anastomosing trabecular streams through the dermis, separated by strands of connective tissue in both cases. In the first case, the tumor cells were positive to cytokeratin and NSE, negative to neurofilament antiagen and LCA.
Abdomen ; Adenocarcinoma ; Aged ; Carcinoid Tumor ; Carcinoma, Merkel Cell ; Connective Tissue ; Cytoplasm ; Dermis ; Humans ; Incidence ; Keratins ; Lung Neoplasms ; Lymphoma ; Neoplasm Metastasis* ; Rivers ; Skin ; Small Cell Lung Carcinoma*

The cutaneous metastasis of pancreatic carcinoma by this technique is rarely reported in the literature. A 67-year-old woman was evaluated for left-sided abdominal pain and a palpable abdominal mass. Abdominal CT confirmed the presence of a solid mass involving the pancreas. Ultrasonically guided percutaneous aspiration biopsy was performed. About six month later, the patient was readmitted with a tender tumor mass at the site of the previous aspiration biopsy. Physical examination disclosed a 4 × 4 cm sized firm, tender tumor mass on the abdomen. Histopathological findings of the tumor mass are consistent with metasta tic lesions from a pancreatic carcinoma. We report a case that suggests cutaneous metastsis of pancreatic carcinoma by fine needle aspiration biopsy.
Abdomen ; Abdominal Pain ; Aged ; Biopsy* ; Biopsy, Fine-Needle* ; Biopsy, Needle ; Female ; Humans ; Neoplasm Metastasis* ; Pancreas ; Physical Examination ; Tics ; Tomography, X-Ray Computed