No abstract available.
Mouth Neoplasms*

No abstract available.
Mouth Neoplasms

According to the reviews of some critical factors, such as incidence rate of oral maxillofacial neoplasm, influence factors of molecular-biology and pathology, and advancement of comprehensive treatments, a new treatment idea-balancing therapeutic idea (BTI) has been put forward to improve the patients' life quality, prolong their survival, and decrease their psychological and physiological pains. The key point of the BTJ is that the doctors should pay much attention to the patients' overall benefit and keep away from the risk of over-treatment based on the fact that it is impossible that cancer cells are killed out at the hiological level. It is important for doctors to let the residual tumor cells be monitored and restricted with body's immune defense system under the condition of normal physiological function and not being destroyed by improper treatment. This is the most important purpose of BTI that let oral cancer become chronic disease authentically and improve the therapeutic safety and efficiency.
Humans ; Mouth Neoplasms

ABSTRACT Presently there is a lack of health-related quality of life (HRQOL) measure and its corresponding utility values for oral cancer and oral potentially malignant disorders (OPMD). This limits patient-centered outcomes for cost-effectiveness evaluations. The study aimed to determine post-treatment HRQOL of patients and ascertained differences between OPMD, early and late-stage oral cancer. A cross-sectional survey was conducted among patients in oral maxillofacial specialist clinics in two public tertiary hospitals. Consented participants were required to complete the EQ-5D-5L questionnaire with the EQ Visual Analogue System (VAS). Kruskal-Wallis test was used to explore differences in values between stages. Multiple linear regression was used to explore factors that influenced the HRQOL. A total of 50 OPMD and 52 oral cancer patients were surveyed. The mean EQ-5D-5L health utility values was 0.842 (n = 50, SD = 0.139), 0.822 (n = 10, SD = 0.150) and 0.626 (n = 42, SD = 0.310) for OPMD, early- and late-stage cancer, respectively. The mean values of the EQ-5D-5L index and EQ-VAS scale showed significant differences between groups and between early- and late-stage cancer with good discriminative properties. Results of the multiple linear regression indicated that ethnicity, income, residency, diagnosis, and treatment modality were able to significantly account for 25% of EQ-5D-5L utility values, F(10,91) = 3.83, p < 0.001, R2 = 0.360. Indian ethnicity, rural location, income less than RM4,360, late-stage cancer, and multi-modal therapies were all predictors of poorer HRQOL. This study evidenced disease severity and treatment modality to greatly impact the HRQOL of patients, in addition to socio-demographic factors such as ethnicity and income.
Quality of Life ; Mouth Neoplasms

Oral cancer is the most common malignant tumor in the head and neck, and is one of the world's top ten malignancies. Microbial infection is an important risk factor of oral cancer. Candida albicans is the most popular opportunistic fungal pathogen. Epidemiological studies have shown that Candida albicans is closely tied to oral malignancy. Animal experimentation have also proven that infection of Candida albicans can promote the development of oral epithelial carcinogenesis. The current studies have revealed several mechanisms involved in this process, including destroying the epithelial barrier, producing carcinogenic substances (nitrosamines, acetaldehyde), inducing chronic inflammation, activating immune response, etc. However, current researches on mechanisms are still inadequate, and some hypotheses remain controversial. Here, we review the findings related to Candida albicans' effect on the malignant transformation of oral mucosa, hoping to provide reference for deep research and controlling oral cancer clinically.
Animals ; Candida albicans ; Carcinogenesis ; Mouth Diseases ; Mouth Mucosa ; Mouth Neoplasms

No abstract available.
Drug Therapy* ; Humans ; Mouth Neoplasms*

No abstract available.
Drug Therapy* ; Humans ; Mouth Neoplasms*

Reconstruction of oral soft-tissue defects following resection of oral carcinomas can be achieved using various techniques including microsurgical tissue transfer. However, there seems to be a role for regional or local flaps. Small to medium-size defects can be functionally reconstructed with the platysma myocutaneous flap as an excellent choice particularly in medically compromised patients not being eligible for free tissue transfer. The present paper reviews the indication, surgical technique, and complications following reconstruction of defects of the oral cavity with the platysma myocutaneous flap.
Head and Neck Neoplasms ; Humans ; Mouth

No abstract available.
Humans* ; Mouth Neoplasms* ; Papillomaviridae* ; Vaccination*

Genetic Therapy ; Mouth Neoplasms ; therapy