1.A Case of Diabetic Gastroparesis Complicated with a Gastric Bezoar.
Ki Hyun BYUN ; Hyo Jin PARK ; Joon Sup YEOM ; Kyung Chul KIM ; Sang In LEE ; In Suh PARK
Korean Journal of Gastrointestinal Endoscopy 1998;18(3):381-386
Diabetic gastroparesis is a common gastrointestinal complication which develops in about 20-30% of patients with longstanding diabetes mellitus. Recent studies have shown that erythromycin stimulates gastrointestinal motor activity by binding on motilin receptors of gastrointestinal smooth muscles and that it improves gastric emptying in patients with diabetic gastroparesis. In this respect, we present a 35-year-old patient with diabetic gastroparesis, complicated with a gastric bezoar, who was successfully treated with endoscopic bezoar fragmentation and oral erythromycin for 3 weeks.
Adult
;
Bezoars*
;
Diabetes Mellitus
;
Erythromycin
;
Gastric Emptying
;
Gastroparesis*
;
Humans
;
Motilin
;
Motor Activity
;
Muscle, Smooth
2.Effect of Roux-en-Y Gastric Bypass Surgery on Plasma Motilin Levels and Hunger in Obese Patients.
The Korean Journal of Gastroenterology 2015;66(3):179-181
No abstract available.
*Gastric Bypass
;
Humans
;
Hunger/*physiology
;
Motilin/*blood
;
Obesity/*blood/physiopathology/*surgery
3.Study on the plasma gastromotin level in ganyu patients with functional dyspepsia.
Jiang-hong LING ; Li-ping HUANG ; Ye-qiang CHEN
Chinese Journal of Integrated Traditional and Western Medicine 2003;23(6):460-466
Adult
;
Diagnosis, Differential
;
Dyspepsia
;
blood
;
Female
;
Humans
;
Male
;
Medicine, Chinese Traditional
;
Middle Aged
;
Motilin
;
blood
4.Effect of Modified Baizhu Powder on Gastrointestinal Functions in Mouse Models with Stomach-cold Functional Dyspepsia.
Xu-wen ZHANG ; Chi ZHOU ; Xiao-tong WANG ; Hai-xiong LIN ; Wei GONG ; Wan-quan TANG
Acta Academiae Medicinae Sinicae 2015;37(4):435-439
OBJECTIVETo explore the effect of modified Baizhu (Rhizoma Atractylodis Macrocephalae) powder on the gastrointestinal function in mouse models with stomach-cold functional dyspepsia. Meanwhile,the mouse models were administered with Shihu (dendrobium), a traditional Chinese drug with cold nature and flavour, to explore the way via which it exert its effect on specific symptoms. Methods: Mouse models with stomach-cold functional dyspepsia were established by ice water and ice NaOH. The effects of modified Baizhu powder and dendrobium on mice were observed in terms of water intake, weight change,small intestine propulsion rate, intestinal absorption function, and effects on ghrelin and motilin.
RESULTSThe modified Baizhu powder effectively increased food intake, water intake, body weight (P<0.05) and swimming time (P<0.01), increased the small intestine propulsion rate and serum D-xylose content (P<0.05), and up-regulated ghrelin (P<0.05). Also, it showed a trend to down-regulate the motilin, although the change was not statistically significant (P>0.05). In contrast,the use of Shihu aggravated symptoms in the mouse models. Conclusion: The changes in ghrelin and motilin levels may be the neuro-endocrine mechanisms via which the modified Baizhu powder and Shihu exert their effects on mouse models.
Animals ; Disease Models, Animal ; Dyspepsia ; Ghrelin ; Intestine, Small ; Medicine, Chinese Traditional ; Mice ; Motilin ; Powders ; Stomach
5.Role of the area postrema of medulla oblongata in the regulation of canine interdigestive migrating motor complex.
Lijian WANG ; Lü ZHOU ; Rui TIAN
Chinese Medical Journal 2002;115(3):384-388
OBJECTIVETo determine the effect of the area postrema (AP) of the medulla oblongata on gastrointestinal interdigestive migrating motor complex (MMC) and the plasma motilin level.
METHODSInterdigestive MMC activities of the antrum and duodenum were recorded by strain gauge implanted on the serosa of 8 conscious dogs. A cannula was intubated in femoral vein for motilin injection. The plasma motilin concentration was measured by RIA. We observed: (1) normal interdigestive MMC activity and fluctuations in plasma motilin concentration; (2) the effects of electrically damaging the AP on MMC activity and plasma motilin level; (3) whether intravenous injection of motilin could induce phase III contractions after the AP was destroyed.
RESULTS(1) Typical interdigestive MMC with phase I, II, III, and IV was recorded in normal dogs. Phase III was concurrent with the peak of plasma motilin level. (2) In damaged AP dogs, antroduodenal interdigestive MMC contractions were suppressed; cyclic, phasic and migratory pattern of MMC was disrupted. Plasma motilin concentration was decreased. Intravenous injection of motilin could not induce phase III contractions.
CONCLUSIONSThe area postrema might play an important role, which is mediated by motilin, on the regulation of interdigestive MMC.
Animals ; Dogs ; Fourth Ventricle ; physiology ; Medulla Oblongata ; physiology ; Motilin ; blood ; Myoelectric Complex, Migrating ; physiology ; Stomach ; physiology
6.Observation on clinical therapeutic effect of acupuncture treatment on functional dyspepsia based on syndrome differentiation.
Yang YANG ; Fen AI ; Chao-yang MA ; Wen-jun WAN ; Hai-yan LI
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(4):411-414
OBJECTIVETo observe the clinical efficacy difference in treatment of functional dyspepsia (FD) between syndrome differentiation based acupuncture and ordinary acupuncture.
METHODSSeventy FD patients were assigned to a syndrome differentiation based acupuncture group (Group A) and an ordinary acupuncture group (Group B) by Excel Software randomization. Zhongwan (RN12 ), Tianshu (ST25), and Zusanli (ST36) were needled as main points for patients in Group A. Meanwhile, different combined acupoints were needled according to syndrome differentiation. Only the same main points were needled for patients in Group B. All patients were needled once per day, 30 min each time, 6 days as one treatment cycle, 2 treatment cycles in total. Fasting serum levels of gastrin (GAS) and motilin (MTL) were determined before treatment and after 2 treatment cycles. 36-item Short-form Heath Survey (SF-36) and Nepean Dyspepsia Index [NDI, including Nepean Dyspepsia Symptom Index (NDSI) and Nepean Dyspepsia Life Quality Index (NDLQI)] were assessed before treatment, after 2 treatment cycles, and one month after treatment.
RESULTSCompared with before treatment in the same group, serum levels of GAS and MLT increased in the two groups after 2 treatment cycles (P <0. 05), but changes were more obvious in Group A (P <0. 05). Compared with before treatment in the same group, SF-36 and NDLQI score increased, and NDSI score decreased in the two groups after 2 treatment cycles and 1 month after treatment (all P <0. 05). Compared with Group B, SF-36 and NDLQI score increased in Group A after 2 treatment cycles and 1 month after treatment (P <0. 05, P <0. 01). But NDSI score at 1 month after treatment was lower in Group A than in Group B (P <0.01).
CONCLUSIONSyndrome differentiation based acupuncture could evidently improve dyspeptic symptoms of FD patients, and significantly improve their quality of life with remarkable curative effect.
Acupuncture Points ; Acupuncture Therapy ; Dyspepsia ; therapy ; Humans ; Motilin ; Needles ; Quality of Life ; Surveys and Questionnaires ; Syndrome
7.Effect of herb-partitioned moxibustion at point on plasma motilin and serum gastrin in patients of diabetic gastroparesis.
Chinese Acupuncture & Moxibustion 2020;40(4):361-364
OBJECTIVE:
To explore the clinical therapeutic effect of herb-partitioned moxibustion at point in patients of diabetic gastroparesis differentiated as spleen and stomach deficiency and retention of turbid dampness as well as its effect mechanism.
METHODS:
A total of 134 patients with diabetic gastroparesis were randomized into an observation group and a control group, 67 cases in each one. In the observation group, herb-partitioned moxibustion at point was adopted, 40 min each time, once a day for 5 times a week. In the control group, itopride hydrochloride tablets were prescribed for oral administration, 50 mg each time, three times a day. A total of 6 weeks of treatment was required in the two groups. Before and after treatment, the gastroparesis cardinal symptom index (GCSI) scores, 4-hour gastric emptying rate, TCM symptom score, as well as the levels of plasma motilin and serum gastrin were observed in the patients of the two groups. Additionally, the clinical therapeutic effect was evaluated in the two groups.
RESULTS:
After treatment, the score of every item of GCSI, TCM symptom scores and the levels of plasma motilin and serum gastrin were all reduced as compared with those before treatment in the patients of the two groups (<0.05), and those in the observation group were lower than the control group (<0.05). Regarding 4-hour gastric emptying rates, which were increased as compared with those before treatment in the two group (<0.05), and the rate in the observation group was higher remarkably than that in the control group (<0.05). The total effective rate was 92.5% (62/67) in the observation group, higher than 74.6% (50/67) in the control group (<0.05).
CONCLUSION
Herb-partitioned moxibustion at point relieves the clinical symptoms in the patients with diabetic gastroparesis and increases the gastric emptying rate, which is probably related to the regulation of the levels of plasma motilin and serum gastrin.
Acupuncture Points
;
Diabetes Mellitus
;
Gastric Emptying
;
Gastrins
;
blood
;
Gastroparesis
;
therapy
;
Humans
;
Motilin
;
blood
;
Moxibustion
8.The Effect of Erythromycin on Gastric Antrum and Low Esophageal Sphincter in the Newborn Rabbit.
Sung Dong CHOI ; Chung Sik CHUN
Journal of the Korean Pediatric Society 2000;43(1):34-42
PURPOSE: We studied smooth muscle strips from rabbit gastric antrum and low esophageal sphincter (LES) to explore the difference between newborn and adult rabbit on erythromycin (EM)- induced contractions. Another aim of this study was to determine the mechanism of LES contractile activities induced by erythromycin (EM). METHODS: Muscle strips prepared from newborn and adult rabbits were stimulated with agonists such as KCl, motilin and EM, and the isometric tensions were measured. To study the underlying mechanism of EM-stimulated contraction of LES, the receptor antagonsts, including tetrodotoxin, hexamethonium, atropine, propranolol and phentholamine, were used. A high concentration of motilin (1 micrometer) was employed to provoke tachyphylaxis. RESULTS: Antral smooth muscle and LES from newborn rabbits developed less active force than those from adult rabbits when stimulated with KCl, motilin and erythromycin, however, the effective concentrations (EC50s) were similar in both age groups. Antral smooth muscle strips showed both tonic and phasic contractions but LES muscle strips showed only tonic contractions. These findings were observed in both newborn and adult rabbits. The contraction force of antral smooth muscle strips in response to agonists was greater than that of LES. The contractile response of LES to repeated motilin or EM administration was markedly decreased. EM- induced contractions of LES were markedly decreased by motilin tachyphylaxis but were unaffected by tetrodotoxin, hexamethonium, atropine or propranolol plus phentolamine. CONCLUSOIN: The data suggest that the contractilities of antrum and LES smooth muscle from newborn rabbit are less than those from adult ones, however, the effective concentratons of EM (EC50) are not different between the two age groups. The results also suggest that erythromycin induces the contraction of rabbit LES via motilin receptor in vitro.
Adult
;
Atropine
;
Erythromycin*
;
Gastrointestinal Motility
;
Hexamethonium
;
Humans
;
Infant, Newborn*
;
Motilin
;
Muscle, Smooth
;
Phentolamine
;
Propranolol
;
Pyloric Antrum*
;
Rabbits
;
Tachyphylaxis
;
Tetrodotoxin
10.Effects of acupuncture on the gastric motivity in patients with functional dyspepsia.
Jian-yong CHEN ; Feng PAN ; Jian-jun XU
Chinese Journal of Integrated Traditional and Western Medicine 2005;25(10):880-882
OBJECTIVETo observe the effects of the acupuncture on the gastric motivity in patients with functional dyspepsia (FD).
METHODSNinety FD patients were randomly divided into 3 groups: the treated group, the control groups, 1 and 2, 30 patients in each group. Patients in the treated group received acupuncture treatment, those in the control group 1 and group 2 orally took Cisapride and Marzulene-s granule respectively. Changes in scores of symptoms, electrogastrographic figure, gastric emptying time estimated by B-ultrasonic examination and plasma level of motilin in the 3 groups before and after treatment were observed.
RESULTSSymptoms were obviously improved in the treated and control group 1 after treatment, which were better than those in the control group 2 (P < 0.01). Gastro-electric frequency and rhythm in the treated group and control group 1 were improved more significantly than those in before treatment (P < 0.01). Gastric emptying time and plasma motilin improved in the treated group and the control group 1 after treatment, when compared with before treatment, the difference was significant respectively (P < 0.05).
CONCLUSIONAcupuncture could significantly improve the gastric motivity of FD patients.
Acupuncture Therapy ; Adult ; Aged ; Dyspepsia ; blood ; physiopathology ; therapy ; Female ; Gastrointestinal Motility ; physiology ; Humans ; Male ; Middle Aged ; Motilin ; blood