No abstract available.
Animals ; Glomerulosclerosis, Focal Segmental* ; Lovastatin* ; Puromycin* ; Rats*

No abstract available.
Alcoholism*

No abstract available.
Dental Arch* ; Humans

No abstract available.
Carrier Proteins* ; Vitamin A*

Aortopulmonary fistula is an exceedingly rare vascular malformation. It is commonly derived after chest injuly or from complication of chest operation and aortic dissection and congenital aortopulmonary fistula is only several cases combined with Tetralogy of Fallot or aortic stenosis. But a congenital aortopulmonary fistula without any hemodynamic abnormalities was not reported. A 56-year old man with exertional dyspnea was admitted. In an examination on admission, there were no abnomalities. Aortography showed an aortopulmonary fistula that branches from the ascending aorta adjacent to the right coronary artery, running to the main pulmonary artery. Transcatheter coil embolization was performed and he was discharged 7 day after embolization without complication. Exertional dyspnea disappeared and careful follow up has be performed periodically.
Aorta ; Aortic Valve Stenosis ; Aortography ; Coronary Vessels ; Dyspnea* ; Embolization, Therapeutic ; Fistula* ; Follow-Up Studies ; Hemodynamics ; Humans ; Middle Aged ; Pulmonary Artery ; Running ; Tetralogy of Fallot ; Thorax ; Vascular Malformations

The concept of workers' participation in occupational health was introduced to Korea recently in relation to primary health care in occupational health. But there is confusion and debate about workers' participation concept. The purpose of this study was to review the concepts of workers' participation and to conduct evaluation the workers' participation status in occupational health and safety. 394 workers and 54 employers (5.6%) in north area of Kyunggi-Do, were selected and interviewed with a questionnaire by a trained interviewer from August to September 1990. In general, the concept of workers' participation is based on industrial democratization and Declaration of Human Rights which had been powerful ideologies in labor movement. Contrary to workers' participation, community participation is rooted in the Health Rights. So, it is necessary to consider concept of workers' participation to improve participation. The results of survey were as follows: 1. Most of companies (71.75) carried out occupational health education to workers in study area. 2. The Occupational Safety and Health Committee (OSHC) were set up in 24.1% among the study companies, and 72.7% of workers among respondents thought that OSHC was helpful to workers health. 3. The workers signed his name to personal health report in 43.1% and the rate of participation in occupational environment examination was 54.9%. 4. The workers prefer the OSHC (39.3%), owner (35.1%) and union (25.8%) as a occupation health organization, but owners prefer OSHC (54.5%), manager (43.2%) and union (2.3%). 5. Among the factors of the general characteristics, the existence of labor union was a major determinant of workers' attitude and level of workers' participation. As we have seen, most levels of workers' participation are low in occupational health. The variable of existence of labor union among the factors was a major determinant of workers attitude and level of workers' participation. Therefore, in order to promote workers health, it is necessary to ponder long deeply on occupational health care system under the viewpoint of workers' participation.
Consumer Participation ; Surveys and Questionnaires ; Education ; Gyeonggi-do ; Human Rights ; Humans ; Korea ; Labor Unions ; Occupational Health ; Occupations ; Primary Health Care ; Surveys and Questionnaires

PURPOSE: The insulin-like growth factor-I receptor (IGF-IR) is a member of the transmembrane tyrosine kinase family that regulates various biological processes. These processes include maintaining optimal cell growth, establishing and maintaining the transformed phenotype, tumorigenesis for several types of cells, and antiapoptosis. This study investigated the immunohistochemical expression of IGF-IR in relation with the expression of the estrogen receptor (ER), the progesteron receptor (PR), proliferative activity (Ki-67) as well as with the other conventional clinicopathlogical parameters in breast cancer. METHODS: This study was performed on paraffin sections from 64 invasive ductal breast carcinoma specimens by immunohistochemistry using rabbit polyclonal antibodies to the IGF-I receptor. RESULTS: IGF-IR expression was detected in 56 (87.5%) cases. The immunohistochemical stains for the IGF-IR were scored according to a semi quantitative scoring system. IGF-IR staining was positively correlated with the ER status, but not significantly with the PR, lymph node status, tumor size, histological grade, and proliferative activity. The Ki-67 labeling index showed a significant correlation with the tumor grade and ER status. CONCLUSION: The IGF-IR may play a role in estrogen-mediated growth and the pathogenesis of breast cancer.
Antibodies ; Biological Processes ; Breast Neoplasms ; Breast* ; Carcinogenesis ; Carcinoma, Ductal* ; Coloring Agents ; Estrogens ; Humans ; Immunohistochemistry ; Lymph Nodes ; Paraffin ; Phenotype ; Protein-Tyrosine Kinases ; Receptor, IGF Type 1

No abstract available.
Pheochromocytoma* ; Pregnancy*

Atopic dermatitis is a common chronic inflammatory skin disease, associated with marked inflammatory cells (of mast cells and eosinophils) and severe itching, which leads to clinical problems in the pediatric population. This study was designed to investigate the inhibitory effects of luteolin liposome solution, that is entrapped the hydrophobic luteolin (one of the flavonoids) into ethosome to improve its stability, by using hapten-induced atopic dermatitis animal model (NC/Nga mice).The luteolin liposome treated mice showed anti-inflammatory effect as evidenced by the lowering of erythema and edema in clinical observation, reduction of inflammatory cell infiltration and epidermal thickness in histopathological examination, when compared with TNCB induced controls. Luteolin liposome solution also reduced the serum IgE level which played important roles in the atopic dermatitis model. These results suggest that luteolin liposome solution has some merit in this formulation showing inhibitory effects for the atopic dermatitis.
Animals ; Dermatitis, Atopic ; Edema ; Erythema ; Immunoglobulin E ; Liposomes ; Luteolin ; Mast Cells ; Mice ; Models, Animal ; Pruritus ; Skin Diseases

BACKGROUND: Acute hypoxia tolerance has been evaluated by the time of useful consciousness, subjective symptoms, cardiovascular changes, visual deterioration, psychological performance, and so forth. But these methods are either subjective, lacking strict objectivity, or too demanding to collect sufficient data. Pulse oximeter monitoring has come to be used not only in hospitals but in the aviation environment. This noninvasive oxygen monitoring apparatus warrants a highly objective analysis to investigate acute hypoxia tolerance. METHODS: Eight healthy male volunteers (20-25 years old) were exposed three times to a simulated altitude of 25,000 ft (7,620 m) at intervals of 7 days. We monitored arterial oxygen saturation (SaO2) and pulse rate by a pulse oximeter. The duration from taking the mask off to the time of 60% SaO2 was regarded as acute hypoxia tolerance. The venous hemoglobin concentration was measured a day before exposure to hypoxia. A questionnaire on the 14 subjective hypoxic symptoms was obtained after hypobaric chamber training. RESULTS: There were neither differences of acute hypoxia tolerance, hemoglobin concentration, nor pulse rate according to the repeated exposure of hypoxia. Four symptoms of sleepiness, fatigue, flushing and thinking impairment were sustained regardless of repeated exposures to hypoxia. But the incidence of symptoms of ear pain, anxiety, abdominal pain were reduced according to the repeated hypoxia. CONCLUSION: With pulse oximeter monitoring there was no difference between the values of time of 60% SaO2 in repeated exposures to hypoxia. The incidence of some subjective symptoms was reduced according to the repeated exposures to hypoxia.
Abdominal Pain ; Altitude ; Anoxia* ; Anxiety ; Aviation ; Consciousness ; Ear ; Fatigue ; Flushing ; Heart Rate ; Humans ; Incidence ; Male ; Masks ; Oxygen ; Thinking ; Volunteers ; Surveys and Questionnaires