No abstract available.

The possible role of Chlamydia trachomatis in non-gonococcal urethritis and chronic prostatitis was investigated by cultural technique in a study of 281 and 215 respectively. Chlamydia trachomatis was isolated from 106(37.7%) of 281 non-gonococcal urethritis patients and 49(22.8%) of 215 chronic prostatitis patients. The effectiveness of tetracycline hydrochloride and doxycycline was evaluated by reculture method after 2 weeks` treatment. Thus in this study Chlamydia trachomatis could appear to play a major etiological roles in non-gonococcal urethritis and chronic prostatitis in Korea. And 2 weeks prescription of tetracycline or doxycycline is efficient for eradication of Chlamydia trachomatis.
Anti-Bacterial Agents* ; Chlamydia trachomatis* ; Chlamydia* ; Doxycycline ; Humans ; Korea ; Prescriptions ; Prostatitis* ; Tetracycline ; Urethritis*

No abstract available.
Leukemia* ; Leukemia, Megakaryoblastic, Acute*

We reviewed 63 urolithiasis patients who were admitted to the Department of Urology, College of Medicine, Yonsei University during the period of 6 months from December, 1983 to May, 1984 to discover hyperparathyroidism in urolithiasis and to evaluate the relationship between PTH and urolithiasis. The following results were obtained. 1. Among 63 urolithiasis patients, there were 47 men and 16 women with a ratio of 2.9: 1 And peak age incidence of urolithiasis occurred in the third and fourth decades (68.3 %). 2. Urinary calculi occurred most commonly in the upper ureter (33.3%) and in decreasing order of frequency kidney and ureter (17.5 %), kidney (16.8 %). 3. In urolithiasis patients, elevated PTH level was found in 5 cases (7.9%) and hypercalciuria was found in 10 cases (15.9 %).And elevated PTH level with hypercalciuria was found in 2 cases(3.2%). 4. In urolithiasis patients, the range of serum calcium, phosphate, protein, albumin and urinaryphosphate, creatinine were within normal limit. And the range of TRP, TRCa were within normal limit, too. 5. Urolithiasis patients with elevated PTH had serum calcium level higher than urolithiasis patients with normal PTH and the difference of the values was statistically significant (P<0.01). But in serum calcium, phosphate, urinary phosphate, TRP and TRCa, the differences of the values between the elevated PTH group and normal PTH group were not statistically significant(p>0.01).
Calcium ; Creatinine ; Female ; Humans ; Hypercalciuria ; Hyperparathyroidism ; Incidence ; Kidney ; Male ; Parathyroid Hormone ; Ureter ; Urinary Calculi ; Urolithiasis* ; Urology

Sebaceous epithelioma is an uncommon and primary neoplasm of sebaceous gland. We report herein a case of sebaceous epithelioma in an 85-year-old female. Physical examination showed a solitary, 2.5 x 3.5cm sized, reddish. irregularly surfaced, and well defined tumor on the intercanthal area. Histopathological findings showed tumor parenchyma. romprised of several large nests of three kinds of epithelial cells, mature sebaceous cells, undifferentiated cells arranged in pa1isade fashion at the periphery of a cell nest, and transitional cells showing beginning fatty vacuolizatiorn of the cytoplasm. Electron micocopy revealed immature dark cells, transitional cells, and mature sebaceous cell which showed many scattered foci of sebaceous ditferentiation characterized by intracytoplasmic lipid droplets and glycogen particls.
Aged, 80 and over ; Carcinoma* ; Cytoplasm ; Epithelial Cells ; Female ; Glycogen ; Humans ; Physical Examination ; Sebaceous Glands

Intraperitoneal adminstration of radioisotopes is suggested to treat the metastatic ovarian cancer in the pertioneal cavity. Administering beta-emitting radioisotopes into the pertioneal cavity allows the maximum energy delivery to the cancerous cells of the pertioneal wall surface while sparing the normal cells located in deep site of the peritoneal wall. In this study, dose estimates of the peritoneal wall are provided to be used for prescribing the amount of 166Ho-chitosan complex administered. The 166Ho-chitosan complex diffused in the peritoneal fluid may attach to the peritoneal wall surface. The attachment fraction of 166Ho-chitosan complex to the peritoneal wall surface is obtained by simulating the ascites with Fischer rats. Both volume source in the peritoneal fluid and the surface source over the peritoneal wall surface are counted for the contribution to the peritoneal wall dose. The Monte Carlo code EGS4 is used to simulate the energy transfer of the beta particles emitted from 166Ho. A plane geometrical model of semi-infinite volume describes the peritoneal cavity and peritoneal wall. A semi-infinite plane of 10 micrometer in thickness at every 1 mm of depth in the peritoneal wall is taken as the target in dose estimation. Greater han 98 percents of attachment fraction has been observed from the experiments with Fischer rats. Given 1.3 microcurie/cm2 and 2.4 microcurie/ml of uniform activity density, absorbed dose is 123 Gy, 8.59 Gy, 3.00 Gy, 1.03 Gy, and 327 Gy at 0 mm, 1 mm, 2 mm, 3 mm, and 4 mm in depth to the peritoneal wall, respectively.
Ascites ; Ascitic Fluid ; Beta Particles ; Energy Transfer ; Ovarian Neoplasms ; Peritoneal Cavity ; Radioisotopes ; Rats, Inbred F344

No abstract available.
Arthritis* ; Tendon Entrapment*

OBJECTIVE: Recently, we have demonstrated that embryonic ventral spinal cord motor neurons(ESMNs), transplanted into the distal stump of the axotomized tibial nerve, can grow into the denervated gastrocnemius muscle and form neuromuscular junctions. Our interest in study was to see whether these newly formed neuronal connections are physiologically active, and to electrophysiologically characterize the reinnervated motor units. MATERIAL AND METHODS: Three to eight weeks after transplantation rats were prepared for electrophysiological recording. Motor unit (MU) action potential and gross EMG were monitored. In eleven out of sixteen transplanted animals single unit and gross EMG were recorded after electrical stimulation of the transplant site. Total of 63 motor units were analyzed for their stimulus threshold (ST), latency and stimulus intensity, which is required to produce maximum firing. RESULTS: ST intensities activating MUs were significantly higher in transplanted animals than in controls. Maximum firing of MUs occurred at less than 1.2×T in the control but greater variation was observed in the transplanted animals ranging from 1.1×T to 1.6×T. No significant differences were found in the latencies of MU's firing following stimulation. MU firing was reversibly blocked by infusion of succinylcholine. CONCLUSION: we characterized the temporal, morphological and electrophysiological parameters of denervated skeletal muscle reinnervated by dissociated grafts of embryonic ventral spinal cord cells. MUs reinnervated by the embryonic motoneuronal transplant were physiologically active, with some properties similar to the MUs of the normal.
Action Potentials ; Animals ; Electric Stimulation ; Fires ; Mice ; Motor Neurons ; Muscle, Skeletal ; Neuromuscular Junction ; Neurons ; Rats ; Spinal Cord ; Succinylcholine ; Tibial Nerve ; Transplants

A clinical study was made on 12 cases of neonatal Group B beta-hemolytic streptococcal (=GBS) meningitis, who were admitted to the department of pediatrics, Dong-San Hospital, Keimyung University during the period of 3 years from Aug 1989 to Jul 1992. The following results were obtained: 1) GBS was cultured in 12 cases (57.1%) among 21 neonatal meningitis admitted during the same period. 2) Male and female ratio was 1.4:1, and 4 cases had early-onset and 8 cases had late-onset. 3) In 6 (50%) out of 12 cases, obstetric factors were noted, including premature rupture of membrane (2 caes), premature delivery(1 case), asphyxia (1 case), cesarean section (1 case) and maternal toxemia (1case). 4) The clinical manifestations were fever (91.7%), lethargy and poor feeding (83.3%),vomiting and irritability (50%), convulsion and bulging fontanel in order. 5) Associated diseases were GBS sepsis (8 cases), pneumonia (2 cases), hyperbilirubinemia (2 cases), etc. 6) Cerebrospinal fluid findings were increased cells(250-12600/mm3), decreased sugar (1-11), increased protim (220-678mg%) and the CBC differential ratio was less than 1.0 in all cases. 7) Overall survival rate was 83.3% with 75% in early-onset disease, and 87.5% in late-onsetdisease. 8) The acute neurologic complications were noted in 5 cases (45.5%) including subdural hemorrhage, brain swelling and cerebral infarction.
Asphyxia ; Brain Edema ; Cerebral Infarction ; Cerebrospinal Fluid ; Cesarean Section ; Female ; Fever ; Hematoma, Subdural ; Humans ; Hyperbilirubinemia ; Infant, Newborn ; Lethargy ; Male ; Membranes ; Meningitis* ; Pediatrics ; Pneumonia ; Pregnancy ; Rupture ; Seizures ; Sepsis ; Survival Rate ; Toxemia

Development of the human colorectal cancer is associated with several distinct genetic abnormalities involving both dominant-acting oncogenes (K-ras, c-src) and tumor suppressor genes (APC, DCC, p53) which undergo inactivation or loss. In colorectal tumors, the common molecular alteration is localized in the 17p13 and 5q21 loci encoding the p53 and the APC gene, respectively. The identification of these genes may help the understanding of the pathogenesis of colorectal neoplasia. In order to determine whether the frequency of the genetic alterations varies with sex, age, tumor size, or site, including pathologic parameters, such as degree of differentiation, tumor stage, mucin component, lymphoid reaction, tumor invasion pattern, vein and nerve invasion, lymph node metastasis, and other parameters, such as disease-free survival, distant metastasis and patient outcome, the authors analyzed the loss of heterozygosity (LOH) of the APC and the p53 genes in paraffin-embedded specimens of 48 colorectal cancers by use of the polymerase chain reaction and restriction fragment length polymorphism. The results were as follows: the LOH affecting the APC was found in 15 out of 31 (48.4%) heterozygous patients, while the LOH of the p53 locus was observed in 11 out of 26 (42.3%) patients. Among 48 patients, the LOH at both the APC and the p53 loci was observed in five (10.4%) patient. No statistically significant associations were found between the LOH of the APC gene and the proposed parameters. The relationship between the LOH of the p53 and the histologic differentiation, lymphoid reaction was significant (P<0.05), but survival was not correlated. Statistically significant associations were found between overall survival of the colorectal cancer patients and distant metastasis, Astler-Coller stage, lymphoid reaction, invasion pattern, nerve invasion, vein invasion, lymph node metastasis, and disease free survival. The above results suggest that the LOH of the p53 genes could be involved in the progression of colorectal cancers. However, neither the LOH of the APC nor that of the p53 have significant association with survival of the colorectal cancer patients.
Colorectal Neoplasms* ; Disease-Free Survival ; Genes, APC ; Genes, p53 ; Genes, Tumor Suppressor* ; Humans ; Loss of Heterozygosity* ; Lymph Nodes ; Mucins ; Neoplasm Metastasis ; Oncogenes ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Veins