Intravascular injection of hydrogen peroxide produces oxygen microbubbles suitable for echocardiographic contrast enhancement. To evaluate the effect of a method of myocardial contrast 2-D-echocardiographic delineation of myocardium during acute coronary occlusion, injection of a fresh mixture of 2ml of 0.2% H2O2 and 1ml of heparinized dog blood into aortic root were made in 12 poenchest dogs 10 minutes after occlusion of left anterior descending coronary artery distal to the first diagonal branch and left ventricular short axis 2-D echocardiographic images at the midpapillary muscle level were obtained. On injection of H2O2 blood mixture normally perfused myocardium was enhanced in echodensity but the area of malperfusion did not change in echodensity. The borderlines between the area of normal perfusion and malperfusion was well delineated. The malperfused area measured at mid papillary muscle level by planimetry area method was 29.7+/-6.0% and 32.6+/-6.7% by endocardial circumferential length method. There was a linear correlation between planimetric estimate of area of malperfusion by H2O2 contrast echocardiography and visual determination of regional wall motion abnormality by 2-D echocardiography(r=0.93, P<0.001). There was no change in heart rate before, during and after H2O2 injection. Infection of H2O2 blood mixture caused bradycardia(8.3%), second degree A-V block(16.6%) and ventricular fibrillation(8.3%). H2O2 clearance was achieved in 3-10 minutes. These findigs suggest that H2O2 enhanced myocardial contrast ehocargiography using 2ml of 0.2% H2O2 and 1ml of blood muxture is an accurate, reproducible, real-time in vivo method of quantifying the extent of myocardial perfusion defect during acute coronary occlusion in dog.
Animals ; Axis, Cervical Vertebra ; Coronary Occlusion ; Coronary Vessels ; Dogs* ; Echocardiography* ; Heart Rate ; Heparin ; Hydrogen Peroxide* ; Hydrogen* ; Microbubbles ; Myocardium ; Oxygen ; Papillary Muscles ; Perfusion*

No abstract available.
Cardiopulmonary Resuscitation* ; Telephone*

No abstract available.
Heart Arrest* ; Resuscitation*

No abstract available.
Encephalitis* ; Humans ; Neurologic Manifestations ; Sweet Syndrome*

p53 plays an important function as a negative regulator of cell growth and also inhibits transformation. It has been hypothesized that p53, acting as a control gene at a G1 check point, may detect DNA damage, slow the cell devision, and allow time for DNA repair. If damage is irreparable, the cell may be driven down into the apoptotic pathway, thus preventing replication of defective cells. In this retrospective study, we investigated the correlation between p53 protein expression by IHC staining and benign breast disease with or without atypical ductal hyperplasia, DCIS and invasive breast cancer. Also We analyzed the association between p53 protein expression and the following prognostic parameters in breast cancer patients; age, tumor size, axillary node involvement, stage, histologic grade, estrogen receptor, and progesteron receptor, and DNA ploidy. And, we investigated the correlation between p53 protein expression and the proliferative index of S phase fraction in diploid breast cancer. The results were as follows ; 1) In histopathological classification, none out of ten benign breast diseases, none out of seventeen fibrocystic disease with atypical ductal hyperplasia patients were p53 protein positive, 3 out of fifteen DCIS (20%), 29 out of eighty-six (34%) invasive breast cancer patients were p53 protien positive.2) There were no significant differences between p53 positivity and age, tumor size, axillary node involvement, stage, histologic grade, ER and PGR status, and DNA ploidy by Fisher's exact test with chi-squre test for trend, in invasive breast cancer. (n=86) 3) In diploid tumor (n=35), statistically significant differences were noted such that high S-phase fraction tumor revealed increased p53 positivity. (p<0.05) We have found that immunopositivity for p53 was detected in 20% of in situ carcinoma, suggesting that p53 mutation can be acquired early in malignant progression. We have also found that there is a strong direct correlation between the amount of mutant protein and tumor proliferation rate. These results are consistent with the hypothesis that wild-type p53 is involved in suppression of the cell cycle.
Breast Diseases ; Breast Neoplasms* ; Breast* ; Carcinoma, Intraductal, Noninfiltrating ; Cell Cycle ; Classification ; Diploidy ; DNA ; DNA Damage ; DNA Repair ; Estrogens ; Humans ; Hyperplasia ; Immunohistochemistry ; Mutant Proteins ; Ploidies ; Retrospective Studies ; S Phase

BACKGROUND: We investigated the prevalence of dementia and mild cognitive impairment (MCI) and their risk factors in an urban community-dwelling elderly people over 65 years old. METHODS: A two-phase investigation was performed from January 2010 to December 2011. In Phase I, all subjects (n=9,485) responded to the Korean version of the Mini-Mental State Examination (K-MMSE). Based on the K-MMSE score the subjects were classified into two groups ('Normal' and 'Cognitive decline'). In Phase II, cognitive decline subjects were diagnosed as dementia or MCI according to the neuropsychological tests and doctor's interview. We also surveyed the socioeconomic and medical factors in Normal, Dementia and MCI groups. And we compared and analyzed the socioeconomic and medical risk factors by multiple logistic regressions in Dementia and MCI group. RESULTS: The prevalence of dementia and MCI was obtained 5.4% and 4.3%, respectively. Old age, alcohol intake, living together, low economic status, jobless in the past, diabetes mellitus, previous stroke, lower BMI and family history of dementia were associated with the increased dementia risk. Higher education, hypertension and physical activity were associated with the decreased dementia risk. And old age, alcohol intake, higher education, previous stroke, lower BMI and physical activity were common risk factors in MCI group. CONCLUSIONS: The prevalence of dementia and MCI was obtained much lower than previous reports. Dementia and MCI patients had common socioeconomic and medical risk factors. It is also important to control the risk factors earlier to prevent the increase of patients in dementia. And in order to prove the hypothesis that early control of the risk factors can decrease the occurrence of dementia, the further prospective studies are needed.
Aged* ; Dementia* ; Diabetes Mellitus ; Education ; Humans ; Hypertension ; Logistic Models ; Mild Cognitive Impairment ; Motor Activity ; Neuropsychological Tests ; Prevalence* ; Risk Factors* ; Stroke

PURPOSE: To assess macular function by multifocal electroretinography after reattachment of macula-off retinal detachment and to evaluate relationship between duration of macular detachment (DMD) and functional recovery. METHODS: Nineteen patients (19 eyes) with macula-off rhegmatogenous retinal detachment underwent pneumatic retinopexy or scleral buckling. Retinal reattachment was obtained successfully in all patients. Duration of follow-up of all patients is at least more than 12 months. Eyes were divided into 2 groups, corresponding to the DMD : Group A (within 7 days, n=9 eyes), Group B (>7 days, n=10 eyes). The amplitudes and implicit times of N1-wave and P1-wave of mfERGs in Area 1 (Ring 1), Area 2 (Ring 1+2) were compared between Group A and B and between Group A and control group. RESULTS: The P1 amplitudes in Area 1 and 2 were significantly different between Group A and B (P<0.05). N1 amplitudes in Area 1 were significantly different between Group A and B (P<0.05), but no significant difference of P1 amplitudes in Area 2 between Group A and B (P>0.05). There were no significant difference of all data between Group A and control in Area 1 and 2 (P>0.05) The implicit times of N1, P1 were not significantly different between Group A and B. CONCLUSIONS: The DMD plays a key role in recovery of visual function after reattachment. The mfERG is a useful tool to evaluate the recovery of macular function after reattachment of macula-off retinal detachments.
Electroretinography ; Eye ; Follow-Up Studies ; Humans ; Retinal Detachment ; Retinaldehyde ; Scleral Buckling

Non-ketotic hyperglycemia (NKH) is recognized both as a direct cause of a precipitating factor of many types of epileptic seizure, including simple partial motor, complex partial as well as reflex motor seizure, choreoathetosis and ballismus. Its association with isolated visual alteration is less known. A 74-year-old diabetic woman with visual complaints manifested as flashing colorful lights (red, yellow and blue) in both visual field with progressive increase in frequency. Among the laboratory tests, NKH of 508mg/dL stood out. Slow waves from the right occipital region maximum at O2 associated with visual symptom were recorded in EEG. Brain MRI showed subcortical T2WI and FLAIR hypointensities in the right occipital lobe with scanty enhancement. Patient was treated with hydration and insulin and her symptoms disappeared after hyperglycemia was corrected. We stress that isolated visual episodes may be initial manifestation of occipital lobe simple partial seizure associated with NKH.
Aged ; Brain ; Dyskinesias ; Electroencephalography ; Epilepsies, Partial ; Epilepsy ; Female ; Humans ; Hyperglycemia ; Insulin ; Light ; Occipital Lobe ; Precipitating Factors ; Reflex ; Seizures ; Visual Fields

BACKGROUND: Dyspepsia is a common problem Functional dyspepsia accounts for 40% of all causes of dyspepsia. In view of biopsychosocial medicine, family is an important social background that is the basis of health care. Therefore we studied the relationship between functional dyspepsia and family function. METHODS: The 64 functional dyspepsia patients group and 64 normal control group who visited the department of family medicine, Pusan national university hospital from December 1996 to June 1997 were enrolled in this study. All were examined with gastrofiberscopy, abdominal ultrasonography, and liver function test. Functional dyspepsia patients were subgrouped into ulcer-like dyspepsia, dysmotilitylike dyspepsia, and nonspecific dyspepsia. Patients not having these symptoms were classified into control group. For evaluation of family function, we used family APGAR. RESULTS: Among 64 functional dyspepsia patients, 50.0%(N=32) had ulcer-like dyspepsia, 26.6%(N =17) had dysmotility-like dyspepsia, and 23.4%(N=15) had nonspecific dyspepsia. Average family APGAR score was 5.83(+/-2.2) in the functional dyspepsia group, and 6.80(+/-2.4) in the control group(t-test, p=0.007). Among the functional dyspepsia group, moderately family functional subgroup was most common(53.1%), but among the control group, highly family functional subgroup was most common (6Z5%). Among subgroups of the functional dyspepsia group, average family APGAR score of dysmotility-like dyspepsia subgroup was lowest. CONCLUSION: Subgroups of functional dyspepsia were as follows; ulcer-like 50.0%, dysmotility-like 26.6%, and nonspecific dyspepsia 28.4%. The family APGAR score of functional dyspepsia patients group was lower than normal control group.
Apgar Score ; Busan ; Delivery of Health Care ; Dyspepsia* ; Humans ; Liver Function Tests ; Ultrasonography

BACKGROUND/AIMS: As an underprivileged population, homeless people have a higher incidence of morbidity and mortality than do non-homeless people. Diabetes mellitus is a chronic disease associated with high complication rates; its incidence is increasing rapidly and it requires prompt, adequate treatment and care. Therefore, we investigated the quality of medical care provided to homeless diabetics in a general hospital and comorbidities associated with diabetes. METHODS: Between March 25, 2011 and December 31, 2012, we retrospectively investigated the medical records of the diabetes patients at a general hospital in Seoul. We assigned the patients into two groups: homeless (n = 82) and non-homeless (n = 242) patients. We subsequently compared the clinical and laboratory findings, comorbidities, and complications between the two groups. RESULTS: The homeless diabetics received treatment less regularly than the non-homeless patients and were diagnosed with diabetes while visiting the hospital for the treatment of other diseases. The homeless patients had higher glycated hemoglobin A1c levels than the non-homeless patients. The homeless patients had a higher rate of other diseases, such as peripheral artery disease, acute infectious disease, intracranial hemorrhage, and pulmonary tuberculosis; a higher incidence of acute infectious disease (odds ratio [OR], 15.671; 95% confidence interval [CI], 5.115-48.070); and a higher prevalence of pulmonary tuberculosis (OR, 6.423; 95% CI, 1.785-23.116) than the non-homeless patients, as determined by multivariate analysis. CONCLUSIONS: Comorbid acute infectious disease and pulmonary tuberculosis were found more frequently in homeless diabetes patients presenting to the hospital than in non-homeless diabetes patients. Therefore, attention should be paid to this differentiating factor.
Chronic Disease ; Communicable Diseases ; Comorbidity* ; Diabetes Mellitus ; Hemoglobin A, Glycosylated ; Homeless Persons ; Hospitals, General* ; Humans ; Incidence ; Intracranial Hemorrhages ; Medical Records ; Mortality ; Multivariate Analysis ; Peripheral Arterial Disease ; Prevalence* ; Retrospective Studies ; Seoul ; Tuberculosis, Pulmonary