No abstract available.
Adenoma* ; Colonoscopy*

No abstract available.
Chemotherapy, Adjuvant ; Colorectal Neoplasms ; Humans

No abstract available.
Organoplatinum Compounds

No abstract available.
Colorectal Neoplasms ; Matrix Metalloproteinases

Cell proliferation and differentiation are regulated by a number of hormones, growth factors. These molecules interact with cellular receptors and communicate with the nucleus of the cell through a network of intracellular signal transduction pathways. A great deal of recent work has defined signal transduction pathways that distinguish malignant from normal cells, and hence identified potential targets for cancer therapy. In colorectal cancer cells, key components of these pathways may be altered by oncogenes through overexpression or mutation, leading to dysregulated cell signaling, inhibition of apoptosis, metastasis, and cell proliferation. The molecular mechanisms and signaling pathways that regulate cell proliferation and survival are receiving considerable attention as potential targets for anticancer strategies. This article was reviewed the role of signal transduction in colorectal cancer, introduce promising molecular targets, and outline therapeutic approaches under development.
Apoptosis ; Carcinogenesis* ; Cell Proliferation ; Colorectal Neoplasms* ; Intercellular Signaling Peptides and Proteins ; Neoplasm Metastasis* ; Oncogenes ; Signal Transduction*

While diverticulosis of the colon is a relatively common disease, a solitary giant colonic diverticulum is rare. Although there exist some theories about the formation of the giant colonic diverticulum, none is really conclusive. The preoperative diagnosis of giant colonic diverticulum is made radiographically with findings of a large, smoothly marginated, round homogeneous radiolucency in the abdomen that is in close apposition to the colon on barium enema examination. Early surgical treatment is necessary since the complication rate is high. One case of giant colonic diverticulum is presented, the clinical, radiologic and pathologic findings are discussed, and the etiology and differential diagnosis, reviewe.
Abdomen ; Barium ; Colon* ; Diagnosis ; Diagnosis, Differential ; Diverticulum ; Diverticulum, Colon* ; Enema

PURPOSE: Diverticular disease of the colon is relatively common in western population and rare in oriental population but in recent years the incidence is steadily increasing in oriental population including Korean, so more concerns and appropriate management are required. METHODS: We reviewed 111cases who had diverticular disease in the colon from January 1988 to May 1998 in the Soonchunhyang University Chunan Hospital. Of 111 cases, 87 cases were treated conservatively and 24 cases received a surgical treatment. RESULTS: The annual incidence increased progressively for the last 10 years. The mean age of the patients at the time of diagnosis was 49.6 years and the most common age-group was forth decades (25%). The diverticula were located in the right colon 89%, left colon 7% and both side 4%. Among 24 surgically treated cases, the most common preoperative diagnosis was acute appendicitis (75%) and the correct preoperative diagnosis was made only 3 cases (13%) who had previous appendectomy history, previous diagnosed history or received barium enema due to recurrent pain attack. The surgical procedures of the colonic diverticulosis were right hemicolectomy (6 cases), ileo-ascending colectomy (6 cases), diverticulectomy (2 cases), segmental resection of transverse colon (1 case), left hemicolectomy (1 case), appendectomy (2 cases), appendectomy with drainage (3 cases), appendectomy with drainage and diverticulectomy (3 cases). The postoperative complication was wound infection in all complicated cases. There was no postoperative mortality. CONCLUSIONS: The outcome of patients in our series is satisfactory despite of diagnostic inaccuracies. Preoperative barium study is recommended in those above the 40 years of age suspected the appendicitis. We recommend surgery for patients after two or three episodes of acute diverticulitis that resolves after medical treatment with antibiotics.
Anti-Bacterial Agents ; Appendectomy ; Appendicitis ; Barium ; Chungcheongnam-do ; Colectomy ; Colon* ; Colon, Transverse ; Diagnosis ; Diverticulitis ; Diverticulosis, Colonic ; Diverticulum ; Drainage ; Enema ; Humans ; Incidence ; Mortality ; Postoperative Complications ; Wound Infection

Despite a recent trend toward increased screening and public awareness for colorectal cancer, 30% of patients present with incurable disease. This study was designed to identify objective criteria that might help surgeons decide which patients with incurable colorectal cancer will benefit from palliative resection. Among 33 patients considered incurable colorectal cancer, twenty one patients underwent palliative resection and twelve patients had bypass surgery. Incidence of postoperative complication after palliative resection was 61.9%(13 cases), and after bypass surgery was 58.3%(7 cases). Among patients treated by palliative resection, one patient required reoperation for postoperative bleeding. The operative mortality after palliative resection was 19%(4 cases), and after bypass surgery was 25%(3 cases). The median survival was 11.4 months for patients treated by palliative resection, and was 9.7 months for patients treated by bypass surgery. These results show that palliative resection can be done safely and effectively in patients with incurable colorectal cancer. We believe this approach improved the quality of the remaining life in these patients.
Colorectal Neoplasms* ; Hemorrhage ; Humans ; Incidence ; Mass Screening ; Mortality ; Postoperative Complications ; Reoperation

BACKGROUND : The purpose of this study was to determine whether the Billroth I method using an EEA stapler is safe, reliable, and easy-to-use for treatment of gastric cancer compared with a distal gastrectomy with conventional manual anastomosis. METHODS : A prospective comparative study was performed between forty patients with EEA stapling and thirty patients with manual suturing during gastroduodenostomies performed during the past three years with respect to operation time, diameter of anastomosis, postoperative clinical course, and post operative complications. RESULTS : The operation time was significantly shortened by about 50 minutes on the average, in the cases where the EEA stapler was used (p<0.001). On postoperative hypotonic duodenography, the diameter of the anastomosis was significantly larger in the cases where the EEA stapler was used (p< 0.001). However, the postoperative clinical course showed no difference between the two groups. Complications, such as anastomotic stenosis and anastomotic leak age were noted only in the cases where manual suturing was used. CONCLUSIONS : A gastroduodenostomy using the EEA stapler might be a faster, simpler and safer pro cedure compared with the gastroduodenostomy using the conventional manual anastomosis.
Anastomotic Leak ; Bezafibrate ; Constriction, Pathologic ; Gastrectomy* ; Gastroenterostomy* ; Humans ; Prospective Studies ; Stomach Neoplasms ; Stomach*