No abstract available.
Humans ; Infant, Newborn* ; Lipoproteins* ; Plasma*

PURPOSE: To evaluate the short-term effects of a single intravitreal injection of bevacizumab (Avastin) for the management of new vessels (NV) associated with proliferative diabetic retinopathy (PDR). METHODS: A non-randomized study of 19 PDR patients (20 eyes) who had active NV was analyzed prospectively. Standardized ophthalmic evaluation was performed at baseline and at weeks 1, 4, and 8 after intravitreal injection of 1.25 mg of bevacizumab. The main outcome measures included changes in total area of fluorescein leakage from active NV and best corrected visual acuity (BCVA). RESULTS: Twenty eyes of 19 patients (12 men [63.2%], 7 women [36.8%]) were included and all patients completed the 8-week study follow-up period. The mean age of participants was 47.05+/-12.48 years. At baseline, NV area was 23.02+/-21.80 mm2. The area of active NV decreased significantly to 4.96+/-9.18 mm2, 1.11+/-4.96 mm2 and 4.55+/-5.11 mm2 (p<0.05) at 1, 4 and 8 weeks after injection, respectively. At week 4, no leakage was observed in 19 eyes. The mean logMAR BCVA improved from 0.59+/-0.49 at baseline to 0.56+/-0.47, 0.55+/-0.73 and 0.51+/-0.50 at weeks 1, 4, and 8, respectively. No significant adverse events were observed. CONCLUSIONS: Short-term results suggest that intravitreal injection of bevacizumab is associated with a rapid regression of retinal neovascularization secondary to PDR.
Antibodies, Monoclonal, Humanized ; Diabetic Retinopathy ; Eye ; Female ; Fluorescein ; Follow-Up Studies ; Humans ; Intravitreal Injections ; Male ; Outcome Assessment (Health Care) ; Prospective Studies ; Retinal Neovascularization ; Retinaldehyde ; Visual Acuity ; Bevacizumab

Circumscribed choroidal hemangioma is a rare, benign, vascular hamartom located frequently at the posterior pole. This may lead to symptomatic visual loss when serous retinal detachment occurs at macular area. WE treated successfully a case of circumscribed choroidal hemangioma associated with serous retinal detachment with laser photocoagulation. So, we report this case with a review of the literatures.
Choroid* ; Hemangioma ; Light Coagulation ; Retinal Detachment* ; Retinaldehyde*

PURPOSE: To evaluate the long-term therapeutic effects of intravitreal bevacizumab on myopic choroidal neovascularization (CNV). METHODS: Medical records of 6 patients who underwent intravitreal bevacizumab injection for myopic CNV and were followed for more than 2 years, were retrospectively investigated. The best corrected visual acuity was compared at 1,3,12, and 24 months after injection. Two years after the injection, a fluorescein angiography and optical coherence tomography (OCT) were performed to evaluate the central macular thickness and leakage of CNV. RESULTS: The mean best corrected visual acuity was 1.16 +/- 0.43 (logMAR), 0.45 +/- 0.21 (logMAR), 0.29 +/- 0.23 (logMAR), 0.14 +/- 0.11 (logMAR), and 0.11 +/- 0.06 (logMAR) at baseline, 1, 3, 12, and 24 months after injection, respectively. CONCLUSIONS: Intravitreal bevacizumab injection for the treatment of myopic CNV was effective in maintaining postoperative visual acuity for 2 years.
Antibodies, Monoclonal, Humanized ; Choroid ; Choroidal Neovascularization ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Medical Records ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity ; Bevacizumab

No abstract available.
Humans ; Urethra* ; Urinary Bladder* ; Urinary Incontinence*

No abstract available.
Humans ; Urethra* ; Urinary Bladder* ; Urinary Incontinence*

PURPOSE: To report a case of bilateral endogenous endophthalmitis in a Streptococcus pneumoniae meningitis patient. CASE SUMMARY: A 45-year-old woman with bacterial meningitis was referred to the ophthalmologic clinic with acute visual impairment in both eyes. The patient's visual acuities were hand motion in both eyes. Ophthalmoscopy revealed inflammation in the anterior chamber and vitreous opacities in both eyes. Streptococcus pneumoniae was isolated in the cerebrospinal fluid sample, but not in vitreal, blood samples. Vision improved to 70/100 in the right eye and 2/100 in the left eye after 8 days of treatment. CONCLUSIONS: Endogenous endophthalmitis constitutes a rare complication of Streptococcus pneumoniae meningitis, and a prompt diagnosis and administration of empirical intravitreal antibiotics can lead to a more favorable visual prognosis.
Anterior Chamber ; Anti-Bacterial Agents ; Endophthalmitis ; Eye ; Female ; Hand ; Humans ; Inflammation ; Meningitis ; Meningitis, Bacterial ; Meningitis, Pneumococcal ; Ophthalmoscopy ; Prognosis ; Streptococcus ; Streptococcus pneumoniae ; Vision Disorders ; Vision, Ocular ; Visual Acuity

PURPOSE: To evaluate the success rate of pneumatic retinopexy and the preoperative factors influencing the results in the rhegmatogenous retinal detachment patients. METHODS: We analyzed retrospectively the preoperative and postoperative retinal findings and postoperative complication in 152 eyes of 150 patients with uncomplicated rhegmatogenous retinal detachment, who had undergone pneumatic retinopexy and were followed up for at least 3 months. We analyzed preoperative factors, including age, sex, location and numbers of retinal tears, duration of retinal detachment, lens status, and refractive error. RESULTS: The success rate of the initial surgery was 72.37%. The success rate was significantly higher in non-high myopic and phakic eyes, and when the retinal detachment was less than 3 quadrants with the retinal break located superiorly. Accordingly, the success rate was 85.87% (79 of 92 eyes). CONCLUSIONS: In the present study, the anatomical success rate of primary pneumatic retinopexy was more than 70%. If pneumatic retinopexy is performed to non-high myopic, phakic eyes, and retinal detachment is less than 3 quadrants with superior retinal break, the surgeon can expect good anatomical outcomes and consider pneumatic retinopexy as a first management in rhegmatogenous retinal detachment patients.
Eye ; Humans ; Postoperative Complications ; Retinal Detachment ; Retinal Perforations ; Retinaldehyde ; Retrospective Studies

PURPOSE: To report a case of fungal keratitis 3 days after intracorneal ring segment (ICRS) implantation for keratoconus. CASE SUMMARY: A 65-year-old woman was referred to our clinic with refractory infectious keratitis in her left eye 3 days after ICRS insertion for keratoconus. Slit lamp examinations revealed infiltrates around the incision site with cellular reaction in the anterior chamber after the ICRS had been removed. Corneal scrapings were obtained for staining and cultures, and intensive topical antibiotics were administered. Initial microscopy and cultures were negative. Despite the use of intensive topical antibiotics, there was no improvement. Hyphae were isolated from additional corneal scrapings. The patient's symptoms and corneal findings improved following administration of topical amphotericin B and oral itraconazole. CONCLUSIONS: Infectious keratitis after ICRS implantation is an uncommon but sight-threatening complication. Fungal keratitis should also be considered if infectious keratitis after ICRS is unresponsive to antibiotics.
Aged ; Amphotericin B ; Anterior Chamber ; Anti-Bacterial Agents ; Eye ; Female ; Humans ; Hyphae ; Keratitis ; Keratoconus ; Microscopy

PCR implication using the primers for gag, pol and rev genes in BLV (bovine leukemia virus) proviral DNA and syncytium assay were carried out for the Korean native goats experimentally infected with bovine leukemia virus to investigate pathogenesis of BLV in the goats, and to establish a model animal for BLV infection. The oligonucleotide primers used in PCR revealed very high specificity, The minimal amount of FLK-BLV cellular chromosomal DNA to detect the integrated BLV proviral DNA was 10 ng. The peripheral blood lymphocytes from the goat infected with BLV were examined at regular intervals by PCR amplification and syncytium assay. Pol or gag genes were detected in none of three infected goats at the 1st week post-infection (p.i.). At the 4th week p.i., one of three goats showed the amplified gag gene. Thereafter detection rates for the genes were increased, indicating that the BLV proviral genes were integrated in all of the lymphocytes from three goats, at the 16th weeks p.i., when it was evident in syncytium assay that the lymphocytes from all of three goats were infested with infective BLV. Investigating the tissues from the necropsied goats at the 8th month p.i., the amplified BLV proviral genes and infective BLV were detected in all of the peripheral lymphocytes from three infected-goats. Among various tissues examined, the amplified BLV proviral genes were observed in spleen and superficial cervical, mandibular and retropharyngeal lymph nodes, and the infective BLV, in superficial cervical and mandibular lymph nodes. It was assumed that the Korean native goat was quite susceptible to BLV infection, indicating that the goat could be a good model animal for BLV.
Animals ; Cattle ; Deltaretrovirus Infections ; DNA Primers ; DNA* ; Enzootic Bovine Leukosis* ; Genes, gag ; Genes, rev ; Giant Cells ; Goats* ; Leukemia ; Leukemia Virus, Bovine* ; Lymph Nodes ; Lymphocytes ; Polymerase Chain Reaction* ; Sensitivity and Specificity ; Spleen