Inversion of chromosome 16 [inv(16)(p13.1q22)] and t(16;16)(p13.1;q22) are associated with acute myelomonocytic leukemia (AMML) with eosinophilia and a favorable prognosis. On the other hand, patients with del(16)(q22) usually present with MDS or chronic myelomonocytic leukemia (CMML), which can evolve to AMML without eosinophilia, and this chromosomal aberration is associated with older age, a complex karyotype, and a poor prognosis. We report a case of AML with del(16)(q22) which showed a complex karyotype, absence of eosinophilia in bone marrow study and a poor response to chemotherapy.
Antimetabolites, Antineoplastic/therapeutic use ; *Chromosome Deletion ; *Chromosomes, Human, Pair 16 ; Cytarabine/therapeutic use ; Daunorubicin/therapeutic use ; Drug Therapy, Combination ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemia, Myeloid, Acute/diagnosis/drug therapy/*genetics ; Male ; Middle Aged ; Monocyte-Macrophage Precursor Cells/cytology ; Prognosis