2.Monoclonal Gammopathy of Undetermined Significance Presented as a Vasculitic Neuropathy.
Sang Soo LEE ; Dong Ick SHIN ; Sung Hyun LEE ; Yun Hui KIM
Journal of the Korean Neurological Association 2006;24(5):524-526
No abstract available.
Monoclonal Gammopathy of Undetermined Significance*
;
Paraproteinemias*
;
Vasculitis
3.Clinical Application of (18)F-FDG PET in Multiple Myeloma.
Nuclear Medicine and Molecular Imaging 2009;43(6):509-512
This review focuses on the clinical use of (18)F-FDG PET to evaluate multiple myeloma. (18)F-FDG PET is useful for diagnosis, staging of multiple myeloma and differential diagnosis of myeloma related disease such as monoclonal gammopathy of undetermined significance or plasmacytoma. For therapy response, (18)F-FDG PET may be effective after chemotherapy for multiple myeloma and radiotherapy for plasmacytoma.
Diagnosis, Differential
;
Monoclonal Gammopathy of Undetermined Significance
;
Multiple Myeloma
;
Plasmacytoma
4.Concurrence of Fibrillary Glomerulonephritis and AL Amyloidosis Associated with Monoclonal Gammopathy.
Dong Suk CHANG ; Won Ik JANG ; Dae Eun CHOI ; Ki Ryang NA ; Kwang Sun SUH ; Yong Tai SHIN ; Kang Wook LEE
Korean Journal of Nephrology 2011;30(2):187-190
Renal diseases with organized deposits include amyloid, fibrillary, immunotactoid, and cryoglobulinemic glomerulopathies. AL amyloidosis and fibrillary glomerulonephritis are different in the composition of their immunoglobulin deposits. Fibrils of fibrillary glomerulonephritis are usually composed of polyclonal, occasionally oligoclonal or monoclonal, immunoglobin G, but amyloidosis consists of monoclonal light chains. Simultaneous occurrence of fibrillary glomerulonephritis and AL amyloidosis is very rare. We report a case of fibrillary glomerulonephritis combined with AL amyloidosis in a 71-yr-old man.
Amyloid
;
Amyloidosis
;
Glomerulonephritis
;
Immunoglobulins
;
Light
;
Monoclonal Gammopathy of Undetermined Significance
;
Paraproteinemias
7.Polyneuropathy Associated with IgA Paraproteinemia and Amyloidosis: A Case Report and Literature Review.
Yunsook JHANG ; Jung Ju LEE ; Jong Moo PARK ; Ja Seong KOO ; Byung Kun KIM ; Ohyun KWON
Journal of Clinical Neurology 2007;3(2):116-119
Paraproteinemia potentially causes peripheral neuropathy via an unknown underlying pathogenetic mechanism. We report a case of pathologically proven amyloid neuropathy with AL amyloidosis with an IgA kappa light chain, which was initially diagnosed as neuropathy associated with monoclonal gammopathy of undetermined significance. This case indicates that in cases of neuropathy with paraproteinemia, the other potential causes should be excluded by appropriate means, especially pathological evaluations.
Amyloid Neuropathies
;
Amyloidosis*
;
Immunoglobulin A*
;
Monoclonal Gammopathy of Undetermined Significance
;
Paraproteinemias*
;
Peripheral Nervous System Diseases
;
Polyneuropathies*
8.Coexistence of AA and AL Cardiac Amyloidosis in a Patient with Ankylosing Spondylitis Accompanying Monoclonal Gammopathy of Undetermined Significance.
Woohyeon KIM ; Seon A KIM ; Kyung Jin YUN ; Soo Jin NA ; Ji In HYUN ; Jung Im JUNG ; Seung Ki KWOK ; Sung Hwan PARK
Journal of Rheumatic Diseases 2014;21(3):151-155
Amyloidosis is a clinical disorder caused by extracellular deposition of proteinaceous insoluble fibrils in various tissues, resulting in organ compromise. Amyloid L (AL) amyloidosis is the most common type of systemic amyloidosis, which occurs in association with multiple myeloma or monoclonal gammopathy of undetermined significance (MGUS). Secondary amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions, such as rheumatoid arthritis or ankylosing spondylitis. We report a case of a 49-year-old manwith a 11-year history of ankylosing spondylitis, who was recently diagnosed with MGUS presented with cardiac amyloidosis of both the AA and AL types. We report this case along with a review of relevant literature.
Amyloid
;
Amyloidosis*
;
Arthritis, Rheumatoid
;
Humans
;
Middle Aged
;
Monoclonal Gammopathy of Undetermined Significance*
;
Multiple Myeloma
;
Spondylitis, Ankylosing*
9.Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis.
Pasquale NISCOLA ; Gianfranco CATALANO ; Stefano FRATONI ; Laura SCARAMUCCI ; Paolo DE FABRITIIS ; Tommaso CARAVITA
Blood Research 2013;48(3):228-230
No abstract available.
Leukemia, Biphenotypic, Acute
;
Monoclonal Gammopathy of Undetermined Significance
;
Multiple Myeloma
;
Paraproteinemias
;
Thrombocythemia, Essential
10.Clinical Analysis of Patients with MGUS, Primary Light Chain Amyloidosis, Multiple Myeloma or Multiple Myeloma with Concurrent Amyloidosis.
Xue-Han MAO ; Shu-Hui DENG ; Wei-Wei SUI ; Ming-Wei FU ; Jia-Hui LIU ; Hui-Shou FAN ; De-Hui ZOU ; Yao-Zhong ZHAO ; Lu-Gui QIU ; Gang AN
Journal of Experimental Hematology 2021;29(3):812-818
OBJECTIVE:
To summarize and compare the clinical baseline characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS), primary light chain amyloidosis (pAL), multiple myeloma (MM), or MM with concurrent amyloidosis, especially the differences in cytogenetic abnormalities.
METHODS:
The clinical data of 15 cases of MGUS, 34 cases of pAL, 842 cases of MM and 23 cases of MM with concurrent amyloidosis were analyzed and compared retrospectively.
RESULTS:
Cytogenetic statistics showed that the incidence of t (11; 14) in the four groups (MGUS vs pAL vs MM vs MM with concurrent amyloidosis) was 0%, 33.3%, 16.4%, and 15.8%, respectively (P=0.037); that of 13q deletion was 20.0%, 14.7%, 45.8% and 56.5%, respectively (P<0.001); gain of 1q21 was 50.0%, 12.5%, 47.4% and 40.9%, respectively (P=0.001). Proportion of pAL patients with 0, 1 and≥2 cytogenetic abnormalities (including 13q deletion, 17p deletion, 1q21 amplification and IgH translocation) accounted for 41.9%, 41.9% and 16.1%, respectively; while the proportion of the same category in MM was 17.6%, 27.3%, and 55.2% respectively; this ratio of MM with concurrent amyloidosis was more similar to MM. Subgroup analysis showed that genetic abnormalities (including 13q deletion, 17p deletion and 1q21 amplification) were comparable within t (11; 14) negative and positive groups. Compared with positive cases, t(11; 14) negative patients with MM or MGUS were more likely to have 13q deletions and multiple genetic abnormalities.
CONCLUSION
Clinical characteristics of pAL, especially cytogenetic abnormalities, are significantly different from MM with concurrent amyloidosis. It suggests that although the onset characteristics are similar, actually the two diseases belong to different disease subtypes which should be carefully predicted and identified.
Amyloidosis
;
Humans
;
In Situ Hybridization, Fluorescence
;
Monoclonal Gammopathy of Undetermined Significance/complications*
;
Multiple Myeloma
;
Retrospective Studies