Introduction: Genus of Artemisia L. is one of the largest (Asteraceae). There are about 84 species in Siberian flora [1]. Artemisia absinthium L. and Artemisia vulgarisL. are mostly used in medical practice. A.vulgaris L. is widely spread in Buryatia as a weed plant and A.absinthium L.grows only in Kabansky district. One of the Absinthium DC section is A. Sieversiana Willd. which also grows in Buryatia. It is known that pharmacological activities of genus Artemisia plants occur due to the essential oils and sesquiterpene lactones. Speaking from the perspective of efficient use of medical plant materials, it is interesting to explore another group of biologically active substances, including flavonoids.The main aim of this work is to identify the presence offlavonoids, and make chemical assay of them in HerbaA. absinthii и A. Sieversianae. To achieve this goal we should make the following tasks: 1) to reveal main anatomical diagnostic features of Herba A. absinthii andA. Sieversianae; 2) to make phytochemical analysis;3) to identify the presence of flavonoids using thin layer chromatography (TLC); 4) to make quantitative determination of flavonoids by spectrophotometry.As a plant material in this research we used Herba A. Sieversianae which was collected in the Republic of Buryatia (Ivolginsky district), in Tomsky region (suburbs of Tomsk) and in Mongolia (suburbs of Ulan-Bator) in 2011-2012 during the flowering period; and HerbaA. absinthii of “Health” Firm manufacturing. To make these tasks we used the next methods: 1) microscopic analysis for revealing main anatomical diagnostic features; 2) phytochemical analysis for identification of biologically active substances; 3) TLC to identify the presence of flavonoids; 4) spectrophotometry for quantitative determination.We made microscopic analysis according to the established article “Technique of microscopic analysis” [2]. The main anatomical diagnostic features of HerbaA. absinthii are flaxuose walls on upper epidermis,anamocytic stomata, numerous T-shaped fuzzes;on both surfaces of epidermis there are large oval trichomes with essential-oi [2]. For HerbaA. Sieversiana they are: cells with curving walls on epidermis; narrow elongate stomata; specific T-shaped fuzzes; it is seen the places of fuzzes’ fixture on epidermis and large trichomes with essential-oil [3]. The identification of flavonoids was made by TLC plates “Sorbfil” with aluminium substrates in solvent system chloroform – ethanol – water (26:14:3) using standard technique [4]. Then these chromatograms should be faced with ammonia gas. There are spots of rutin which coloured into dark-brown in UV spectrum (Rf 0,73). We identified essential oils, flavonoids, coumarins and polysaccharides using standard identity tests [5]. And quantitative content of flavonoids calculated as rutin was determined by spectrophotometry (λ=410 nm), and the results: in plant raw material from “Health” Firm manufacturing – 0,03%, raw material which was collected in the Republic of Buryatia – 0,85%, in Tomsky region – 0,39% and in Mongolia – 0,52%. For making extract we used 70% ethanol (proportion of raw material and extraction fluid 1:20) [6].In general, we identified the main anatomical diagnostic features of Herba A. absinthii and A. Sieversianae, made phytochemical analysis and quantitative determination of the sum of flavonoids calculated as rutin.References:1. Krasnoborov I.M. The flora of Sibiria. – Novosibirsk:Nauka, 1992.2. State Pharmacopoeia of the USSR. Ed. XI (part 2). Common methods of analysis. Medical plant material / USSR Ministry of Health. - 11th ed., Ext.– M.: Medicine, 1990. - 400 p.3. Bereznegovskaya L.N., Serih E.A. Some pharmacognostic issues about wild and cultivated plants in Sibiria. – Tomsk: Publishing center of Tomsk State University, 1969.

Foundation of the research: The issues of safety and qualified medicine industrial, supplyment andmaintenance is the counterpart of national security policy about any nations. Mongolia has been importingover 80% of domestic demand of medicine. New drugs have accessed into marked, and medicine distributersor suppliers, pharmacies have established as many, thus its generating the needs to improve the legal environfor to reach the new level of quality control, medicine suppliers structure and activities, then also to verifythe safety of imported or local medicine. May having formulize the requirements of medicine warehouse,remodify the standard of Medicine Supply Organization can be the first step to solve the problems whichMedicine Supply Organization has been facing. The purpose and goals of research work:Submitting following goals in the frame of the purpose to analyze the condition of the Medicine SupplyOrganization’s warehouse, study the foreign country’s GSP and utilize the standard instruction of medicinewarehouse by determine the method of access it into Mongolian bigger Medicine Supply Organization.The methodology: Have selected and incorporated with 5 top company which are operating as medicineimporter based on value of imported products for last 3 years and 3 The pharmaceutical wholesale centerwhich had lesser scope and totally means 8 companies. We used following methods such as observationstudy, open review survey, schematic and comparative study, method of interview and review anddocumentation method.Conclusion:1. However, that research involved The pharmaceutical wholesale center have reached 71% of therequirement of MNS 5530:2009 standard of Medicine Supply Organization and fitted in low risk categoryas 20% according with the risk assessment of State Specialized Inspection Agency, but was lower by68% than building construction standard and activities according with the GSP’s guidance.2. Have determine the solutions for resolvable factors which are unreached the requirements of GSP basedon the study of World Health Organization, European Union GSP requirements, Kazakhstan, Bulgaria,Germany and Russian by linked it with the condition of research involved organizations.3. Utilized the Mongolian medicine warehouse standard guidance.

Introduction: Polygonum aviculare L. (Polygonaceae) is an annual plant. There are about 300 species of genus Polygonum. Polygonum aviculare is a weed plant which is widely spread in Russia and the Ukraine. All the aerial parts of plant can be used as a medicinal plant raw material. It is extensively used in traditional and official medicine for treatment of urinary diseases [1].The aim of this work is to make Pharmacognostic analysis of Herba Polygoni avicularis and to identify the main biologically active substances. To achieve this goal we should make the following tasks: 1) to do macro- and microscopic analysis; 2) to make phytochemical analysis; 3) to identify a quantitative determination of the sum of flavonoids according to the State Pharmacopoeia of the USSR. Ed. XI (part 2).As a plant raw material in this research we used HerbaPolygoni avicularis of “LEK+” firm manufacturing.During the work we found out the concordance of “general appearance” according to the macroscopic analysis, as there were pieces of caulis, leaves, blooms of different shapes with greenish-grey colour and faint odour. Also, during the microscopic analysis we identified the main anatomical diagnostic features which are straight cells on epidermis with thickened walls and brown contents, numerous crystals of calcium oxalate in mesophyll, the presence of mechanical fibers with curving outlines and thickened layers [2]. Moreover, we made purity tests and identifiedquantitative determination of flavonoids. The results: sum of flavonoids calculated as avicularin – 5,2% (should be not less than 0,5 %) by spectrophotometry (λ=410 nm); loss on drying (where we dried our raw material (t=1070C) in a drying closet, weighed up and calculated) - 12% (not more than 13%); total ash (we burned out organics in an ash muffle) – 5,8% (not more than 13%), foreign organic matter – 0,3 % (not more than 2%) and mineral impurity – 0,5% (not more than 2%) [2]. We identified the presence of flavonoids, tannins, polysaccharides and saponins using standard identity tests [3].In general, during the Pharmacognostic analysis of Herba Polygoni avicularis we set up the correspondence of main characteristics to the general pharmacopeial monograph. We identified the presence of flavonoids, tannins, polysaccharides and saponins.References:1. http://medicalherbs.sci-lib.com/herbs042.html2. State Pharmacopoeia of the USSR. Ed. XI (part 2). Common methods of analysis. Medical plant material / USSR Ministry of Health. - 11th ed., Ext.– M.: Medicine, 1990. - 400 p.3. Grinkevich N.I., Safronich L.N. Chemical analysis of medical plants. – M.: Higher school

Introduction: Rheum palmatum L. var. tanguticum Maxim. (Polygonaceae) is one of the well-known Pharmacopeial plants, which is widely used for treatment and prevention of diseases of the digestive system. It has a wide range of pharmacological activity: antiseptic, increasing appetite, hypotensive, astringent and laxative effects. The aim of this work is to make a Pharmacognostic analysis of radices Rhei tangutici. To achieve this goal we should make the following tasks:1) to do macro- and microscopic analysis; 2) to make purity tests of plant material; 3)to identify the presence of main biologically active substances; 4) to make a chemical assay of anthracene derivatives in radices Rhei tangutici.A homeland of Rheum tanguticum is Central China and northeastern Tibet. Radices rhei contain 2 - 6% of antraglikosides, a number of which increases with age. Also they contain tannins, resins, pectin substances and a lot of starch. Antraglikosides have a laxative effect which is caused mainly by emodin, rhein and chrysophanic acid (they irritate interoceptors of colon which causes the strengthening of vermicular movement) [1].For the research we used radices Rhei tangutici which were collected in Mongolia in 2012. A plant material is pieces of roots and rhizomes with cylindrical, slightly curved forms and a laterally-savoyed surface; the color is dark brown (on a cleavage - yellow-brown), with characteristic aromatic odour. Microscopic analysis revealed that the main diagnostic features are medullarry rays, 2–4 cells in width; phloem consists of thin-walled cells with round containers with slime, parenchyma possess cluster crystals of calciumoxalate and starch grains. Also we made purity tests and identified moisture - 7% (should be not more than 12%), total ash – 7,8% (not more than 8%), 10% chlorohydric acid-insoluble ash – 0,9% (not more than 1%), roots which discolored to black - 2% (not more than 5%), foreign organic matter 0.1% (not more than 0.5%) and 0.1% of mineral impurity (not more than 0.5%) [2]. In this material we found out the presence of anthracene derivatives (emodin and chrysophanic acid), polysaccharides, tannins and flavonoids using standard identity tests [3]. According to the quantitative analysis of anthracene derivatives in radices Rhei tangutici, performed by spectrophotometry, it contains2.8 - 3.03% calculated as istizin (should be not less than 2%) [2].Thus, the main Pharmacognostic analysis’ characteristics of radices Rhei tangutici, which grows in Mongolia, conform to the pharmacopeial article ¹ 68 (State Pharmacopoeia of the USSR, ed.11, part 2).References:1. Korenskaya I.M., Ivanovskaya N.P. Medicinal plants and medical plant material containing anthracenes, phenols, lignans, tannins. - Voronezh: Publishing center of Voronezh State University, 2007. - 87 p.2. State Pharmacopoeia of the USSR. Ed. XI (part 2). Common methods of analysis. Medical plant material / USSR Ministry of Health. - 11th ed., Ext.- Moscow: Medicine, 1990. - 400 p.3. Grinkevich N.I., Safronich L.N. Chemical analysis of medical plants. -Moscow: Higher school, 1983.- 176p.

Introduction: Carum carvi L.s I. is a biennial herbaceous plant of the genus Carum (Umbelliferae/ Apiaceae). Carum carvi seeds are medicinal raw material. Today Carum carvi is widely used in folk medicine and sometimes is used in official medicine of different countries [1]. Widespread use of fruits of Carum carvi has increased the number of manufacturers. Unfortunately, at the same time the number of cases of the poor quality of raw materials was increased. The aim of this work is to make the Pharmacognostic analysis of fruits Carum carvi and to find out the quality of essential oil extracted from the fruits of Carum carvi. To achieve this goal we should make the following tasks: 1) to make Pharmacognostic analysis; 2) according to the State Pharmacopoeia of the USSR. Ed 11 (part 2) to make quantitative assay of the sum of essential oils in the fruits; 3) to do phytochemical analysis; 4) to determine the quality of essential oil in the fruits of Carum carvi.A plant material of our research is fruits of Carum carvi production of CJSC “Ivan tea”.During the work we found out the concordance of “general appearance”. It is the presence of two mericarps, five longitudinal ribs, matching the size of the seed and the organoleptic characteristics which are described in pharmacopeial monograph on the fruits of Carum carvi [2]. We also identified the main anatomical diagnostic features which are essential-oil tubules located between ribs; thickened walls of the endosperm. We identified moisture - 6% (should be not more than 12%); damaged, immature fruits of Carum carvi and other parts of the plant – 0,4% (not more than 2%), organic impurities – 0,1% (not more than 2%), mineral impurities - 0,1% (up 0.5%). We also made a sieve analysis [2], in which we have identified the number of particles that have not passed through the sieve of 1 mm diameter (0.77%). Total ash content in the fruits of Carum carvi was 5% and 10% hydrochloric acid-insoluble ash 0,8%. We found out that the quantitative content of essential oil in fruits of Carum carvi calculated on dry substance was 2% (should be not less than 2%). Also phytochemical analysis was carried out on the base of standard identity tests [3], during which essential oils, flavonoids, tannins and coumarins were found. To determine the quality of essential oil of Carum carvi fruits we needed to identify one of the main characteristics of quality - the index of refraction. This figure amounted to n 20 = 1.4870 (1,484-1,493) [4].Thus, during the Pharmacognostic analysis of Carum carvi fruits we set up the correspondence of main characteristics to the general pharmacopeial monograph. We identified the presence of essential oils, flavonoids, tannins and coumarins. The quality of essential oil with refractive index corresponds to the technical standard documentation [4]. References:1. Samylina I.A., Muraeva D.A., Yakovlev G.P. Pharmacognosy. – M: Medicine, 2007. – 656 p.2. State Pharmacopoeia of the USSR. Ed 11 (part 2). Common methods of analysis. Medical plant material / USSR Ministry of Health. - 11th ed., Ext.- M: Medicine, 1990. - 400 p.3. Tikhonov V.N., Kalinkina G.I., Salnikova E.N. Medical plants, plant material and phytopreparations. – Tomsk, 2007.4. Voitkevich S.A. Volatile oils for perfumes and aromatherapy. - M: Food Industry, 1999. - 245 p.

Introduction: It grows a larch and Siberian Pine forest, in its meadow, edge and glade, bank of the river and thick bushes forests covering Khuvsgul, Khentii, mountainous and fertile pastures, Mountain range, Khovd and Mongol Altaic Mountain range. Leaves of Cacalia hastat, its preparation is effective to release poisoning, reduce inflammation, support liver and gall procedure internal treatment and an external application for inflammation, fast healing, edema decreasing. Drug preparations extracted from upper part of the land is against over oxidation, confirming cell membrane, protecting stomach side. Its leaves are for fast healing scald and inflammation, gallbladder diseases, poison fever and decreasing fever in Mongolian traditional Medicine But the root is for releasing poisoning and cold treatment.Goal: The aim is to have study of phytochemicalCacalia hastata leaf.Materials and Methods: We performed the research taking material assistance of pharmacognozy laboratories in Monos university from 2012-2013. The quantitative and qualitative analyses of plant bioactive compounds were evaluated by Russian XI Pharmacopeia and the method according to Mongolian National Standard. Result of the study was developed by SPSS 16 and End notе programme.Result: The quantitative and qualitative analyses of plant bioactive compounds of Dianthus superbus upper part of the land were evaluated by Russian XI Pharmacopeia and the method according to Mongolian National Standard and alkaloid, tannin, coumarone, flavonoid and natural active substances were found.Conclution: It was carried out phytochemical investigation of the Cacalia hastata using spectrophotometer as a result we determined that it contains 8.53 % of sum flavonoid, 12.3 % coumarone. Amount of biological active compound-tannins was 15%, alkaloid 0.0074 %.

Backround: Reading is an essential part of language teaching at every level because it supports learning in multiple ways. Reading skills can often be challenging to teach. Some students are natural readers; others need extra help and guidance to improve their reading level. Though your student must be self-motivated and willing to learn, you can do much in your role as teacher to encourage him and help speed the process of improving his reading.Teachers can help students learn when and how to usereading strategies in several ways.• By modeling the strategies aloud, talking through the processes of previewing, predicting, skimming and scanning, and paraphrasing. This shows students how the strategies work and how much they can know about a text before they begin to read word by word.• By allowing time in class for group and individual previewing and predicting activities as preparation for in-class or out-of-class reading. Allocating class time to these activities indicates their importance and value.• By using cloze (fill in the blank) exercises to review vocabulary items. This helps students learn to guess meaning from context.• By encouraging students to talk about what strategies they think will help them approach a reading assignment, and then talking after reading about what strategies they actually used. This helps students develop flexibility in their choice of strategies.The aim of the researchThe aim of the research is to investigate how studentsthink about reading and do they like to read.The research method: A “questionnaire” is used to determine students’ enjoyable experience in learning the reading.Result from questionnaire: This questionnaire is taken from 1 year students of “Monos” institute. There were involved 78 students. 67 percent of students answered that they sometimes read about their reading habit. That means reading is non-regular activity for our students.In this case students answered that they read a book. Reading a book is possible data about reading habit. That means 86% of the students read and understand the text in English slowly.60% of students answered “yes”. That means our students think reading in English is useful for them to learn English. 41% of students answered that they understand the main idea of the text after reading two times. That means our students’ reading ability is not too bad.Conclusion1. As you look at this questionnaire students still liketo read in English, which is very good sign.2. As teachers we need to encourage them as well asmake them understand the marvel reading.3. Without reading no reflecting and without reflecting you can’t speak in any language, also it belong to mother language.References1. Max Koller . English teaching Forum 20072. Vale D. Practical English 20043. Smith B. Through Writing to Reading. London4. www.liaconferences.com

Foundation of the research: The issues of safety and qualified medicine industrial, supplyment and maintenance is the counterpart of national security policy about any nations. Mongolia has been importing over 80% of domestic demand of medicine.New drugs have accessed into marked and medicine distributors or suppliers, pharmacies have established as many, thus its generating the needs to improve the legal environ for to reach the new level of quality control, medicine suppliers structure and activities, then also to verify the safety of imported or local medicine.May having formulize the requirements of medicine warehouse, remodify the standard of Medicine Supply Organization can be the first step to solve the problems which Medicine Supply Organization has been facing.The purpose and goals of research work: Submitting following goals in the frame of the purpose to analyze the condition of the Medicine Supply Organization’s warehouse, study the foreign country’s GSP and utilize the standard instruction of medicine warehouse by determine the method of access it into Mongolian bigger Medicine Supply Organization. Thereof:1.Make analysis and assessment on the current condition of Mongolian Medicine warehouse.2.Conduct the research work based on the guidance of World Health Organization, European UnioN warehouse standard and other foreign country’s warehouse standard.3.To utilize the medicine warehouse standard guidance for Mongolia.The methodology: Have selected and incorporated with 5 top company which are operating as medicine importer based on value of imported products for last 3 years and 3 The pharmaceutical wholesale center which had lesser scope and totally means 8 companies.We used following methods such as observation study, open review survey, schematic and comparative study, method of interview and review and documentation method.THE RESULT OF RESEARCH WORK: Even though,those research involved organizations have met with the requirements of MNS 5530:2009 Medicine Supply Organization Standard by 71%, and risk assessment was in low risk category as by 20% under the State Specialized Inspection Agency, but accordingly with the World Health Organization’s formulized GSP’s guidance, it haven’t freezing and cooling chain storage condition of medical product storage. Research involved The pharmaceutical wholesale center provides activity supervision indication of GSP’s guidance by 30%, required parts of warehouse structure by 43% and supportive parts of warehouse operation by 22%.CONCLUSION:1. However, that research involved the pharmaceutical wholesale center have reached 71% of the requirement of MNS 5530:2009 standard of Medicine Supply Organization and fitted in low risk category as 20% according with the risk assessment of State Specialized Inspection Agency, but was lower by 68% than building construction standard and activities according with the GSP’s guidance.2. Have determine the solutions for resolvable factors which are unreached the requirements of GSP based on the study of World Health Organization, European Union GSP requirements, Kazakhstan, Bulgaria, Germany and Russian by linked it with the condition of research involved organizations.Utilized the Mongolian medicine warehouse standard guidance.

There are 56 private pharmaceutical universities (or universities with a pharmaceutical department) in Japan, or approximately three times as many national or public universities with a pharmaceutical department (17 universities). Presently, over 10,000 students a year enroll in these private universities, approximately eight times as many in national or public universities. Pharmaceutical programs in Japan have two main objectives: the education of future pharmacists, as well as scientists. All Japanese pharmacists are required to pass the national pharmaceutical examination and obtain a license for practice. To partake in the national examination, candidates must receive a diploma from a pharmaceutical department of a university. Therefore, private pharmaceutical universities produce the majority of the nation’s pharmacists, playing a central role in the Japanese medical care system.The diploma program to become a pharmacist takes 6 years, with the course of study including basic science (chemistry, biology, physics) and “cultural subjects” (second languages, philosophy, mathematics) in the first year, and “specialized subjects” including organic chemistry, biological chemistry, physiology, and pharmacology from the second year on. Pharmacognosy, as well as traditional medicines commonly used in Japan, such as Kampo or medicinal plants, also comprise a portion of the lectures students are required to take. In addition, approximately 20 lectures including experiment skills are required during the course of study for students to study scientific and pharmaceutical skills, which include introductions to synthesis of some medical drugs as well as animal testing. Because academic credit must be obtained for nearly all courses, approximately 10-30% of students either require a course repeat or drop out entirely up until the fourth year of the program. After students pass the “Objective-Structured Clinical Examination” at the end of their fourth year, students begin their practical experience at hospitals and pharmacies their fifth year. In the sixth year, students study for the national examination. Subsequently, graduates with specific knowledge and skills for working as pharmacists leave these universities and are depended on as specialists of pharmacy and drugs by the public.Education for future scientists (researchers) is another important objective of private pharmaceutical universities. Some universities include a program of study for pharmaceutical research skills over the course of 4 years. To become a researcher, students continue on to graduate school to study and conduct laboratory research in their particular specialty the 4 years following their 6 year pharmacist course, or a 2 plus 3 year course (after the 4-year undergraduate degree) for the doctorate program. Students graduating with a Ph.D have access to a large variety of job opportunities, including becoming researchers at pharmaceutical companies, universities, or pharmaceutical agencies, or professional pharmacists. These 6- and 4-year programs were initiated and adapted in 2006; prior to 2005, all university pharmaceutical programs were 4-year courses. One reason underlying this longer program is the increasing workload necessary of pharmacists, requiring more specific and clinical knowledge. The above-mentioned points are the positive aspects of the private pharmaceutical universities of Japan, which have provided many pharmacists to match the recent needs of the medical care system. On the other hand, some problems regarding this system have recently been brought to light, such as an excess production of pharmaceutical students, which may cause problems for students, universities, and the public.Due to this, continuous improvement of the programs at private pharmaceutical universities is required.

Background: In Mongolia, leading cause of morbidity prevalence is respiratory system disease by 2010. The prevalence is 1027,73 per 10000 people. Comparison to 2000, it has been increased by 1,5-2 times. Another word, it shown that respiratory diseases hadn’t been decreased, but progressively increased in the last 10 year.By WHO estimation in 2008, future trend of mortality rate of the respiratory system disease would taken 3rd place in the leading causes of the mortality by 2030. Most common symptoms of the respiratory diseases are cough and sputum.Aim of the study: Aim of this study is to investigate some effects Sorool-4 drug on some respiratory diseases.Method of study: Experimental research method was used in this study. 30 laboratory white mouse, each weigh is 18-22 grams and 40 Vistar species rats, each weigh is 180-220 g were used in the study in where Inner Mongolian National University of China.0.25% Ammonium hydrochloridium solvent was inhaled to each mices for 10 seconds. After 3 day inhalation procedure, Sorool-4 drug was injected 10 grams per kg to mices, and Libexin was administered 4.3mg/kg per one time in next 3 day. During these 3 days, we measured cough for 3 minutes to each mices by ZOLY- 3 devices in everyday.White mices were classified into 3 groups, and then0.1 ml/10gram phenol aldehyde solution 0.2-0.25 ml per each mice injected to abdominal cavity. After 3 day injection, sorool-4 was administered 10 gram per kg and bromhexine 0.12 mg per kg, 3 times a day, for 3 days.Bacterial colony: Coagulase positive S.aureus DU 5789 and coagulase negative mutant DU5843 species were used in this study. These bacterias has stored in-700C in brain and heart infusion, and 10% glycerol and 5% non-fat milk were feed until used.Culture: According to CASH method, some changes were made. S.aureus was cultured in the TSA, BBL agar in +370C for 24 hours and diluted with pure non- endotoxin saline and centrifuged at 3000rpm for 7 days, +40C, 10 min per day. And then again diluted with cold pure saline, and diluted to 2х109-4х109 CFU ml by turbid meter. Prepared suspension has warmed to 450C, and mixed 10 ml suspension with 4% 10ml melted NOBLE agar.Experimental model: 0.2-10ml/10ml/g agar wasinjected to every mice tail vein.To develop cough model, 0.25% ammonium hydrochloridium solution was inhaled 10 sec for 3 days in YLS-8A device. After 3 day, in three groups, mices of the each group coughed mean 25.6±3.6 amount. Sorool-4 drug and Libexin were administered 10mg/kg to treatment group 1 and 4.3 mg/kg to treatment group 2, each respectively. After administration these drugs, counted cough amount of each mice for 3 min in YLS- 8A device in 3 day.Conclusion: Because of amount of sputum of treatment group 1 and 2 is more than control group, Sorool-4 is not efficient as same as bromhexine, but this showed that it has mucus expectorant effect.As shown results, sorool-4 has anti-inflammatory effect. It would be more effective using sorool-4 with antibiotic.