Juvenile Hyalin Fibromatosis is a rare congenital disease that is characterized by large tumors, especially on the scalp, small whitish nodules, hypertrophy of the gingiva, and flexural contractures of the large joints of the limbs. A review of the world literature disclosed 13 similar cases, under various names. This case is the 14th case in the literature and the first case in Korea. A 3 year old girl had multiple large tumors and nodules on various parts of the bodis, hypertrophic gingiva, and flexural contracture of the elbow and knee joints. The histopathologic features of the tumor were characteristic of Juvenile Hyalin Fibromatosis. The tumor cells were embedded in an amorphous eosinophilic ground substance. Diagnosis was confirmed by clinical features and histopathological findings.
Child, Preschool ; Contracture ; Diagnosis ; Elbow ; Eosinophils ; Extremities ; Female ; Fibroma* ; Gingiva ; Humans ; Hyalin* ; Hypertrophy ; Joints ; Knee Joint ; Korea ; Scalp

Lidex' cream (Fluocinonide 0.05% in FAPG base) is a new fluorina,ted topical corticosteroid, and its clinical effect was assessed by applying topically three to four times daily to the lesions of 50 patients with a variety of inflamrnatory skin condi- tions. The results revealed excellent effect in 16 patients, moderate effect in 23 patients, slight improvement in 9 patients, and no effect in 2 patients. No unfavorable side effects were noted except blanching. The findings suggest that fluocinonide is an excelIent addition to the topical corticosteroid agents that are available for clinical use at the present time.
Fluocinonide ; Humans ; Skin

Human wart diseases are benign skin tumors caused by viruses of the papova group which usually affect children and almost always regress until adulthood. Various therapeutic modalities have been tried for the treatment of warts, however there is no single satisfactory method and the clinical course as well as the prognosis is always variable. The spontaneous regression of warts may represent an increase in the activity of host immune responses. Recent studies have tended to confirm that serum antiviral antihodies and cellular immune responses occur in relation to regression of warts, but there is no convincing evidence of a correlation between the appmrance of immune responses and resolution of the warts. BCG and some of similar extra,cts have becn known to be capable of initiating a wide range of non-specific immune reactions to cancerous diseases. The aim of the present investigation has been to study no-specific irnmune response of Tubercin-3 in patients with svarts, based on the findings that RCG and some of similar extracts were found to be a potent reticuloendothelial stimulant. Taventy casee attending a, dermatolo-ical out-ptient department consists of eight verrua plana juvenilis, seven verruca vulgaris, one verruca plxntaris and four molluscurn contagiosum were trezted with Tubercin-R. The results revealed complete cure in six(37. 5.) and clinical improvemeat in nine. (56. %) of sixteen cases of various warts, and one of four czses of molluscum contagiosurn showed a slight decrea,se in size and nu!nber of the lesions. There is no eviclence of a correlation among the age of patient, type of verruca and therapeutic effect. On the basis of our findings, we can state that non-specific immune response of BCG .and some of similar extracts may be facilitate the involution of warts. The relationship of thes immune respons to the involution of warts clezrly require further study.
Child ; Humans ; Immunity, Cellular ; Mycobacterium bovis ; Prognosis ; Skin ; Warts*