1.The association of smoking with components of the metabolic syndrome in non-diabetic patients.
Mojgan GHARIPOUR ; Roya KELISHADI ; Nizal SARRAFZADEGAN ; Abdolmehdi BAGHAEI ; Mehrdad YAZDANI ; Jafar ANARAKI ; Babak ESHRATI ; Ali Akbar TAVASSOLI
Annals of the Academy of Medicine, Singapore 2008;37(11):919-923
INTRODUCTIONThere is limited evidence about the association between smoking and metabolic syndrome (MS). The aim of this study was to assess the association of smoking with MS components.
MATERIALS AND METHODSAs part of the baseline survey of a community-based study, we studied 5,573 non-diabetic men. All participants were interviewed and underwent physical examinations and blood collection.
RESULTSThe study participants comprised 1,625 smokers and 3,948 non-smokers, with a mean age of 38.07 +/- 14.85 years. Serum low-density lipoprotein-cholesterol (LDL-C) and triglycerides (TG) were higher in smokers than in non-smokers (LDLC: 115.34 +/- 39.03 vs 112.65 +/- 40.94 mg/dL, respectively, P = 0.015 and TG: 175.13 +/- 102.05 vs 172.32 +/- 116.83 mg/dL, respectively, P = 0.005). Body mass index, waist circumference and waist-hip ratio were lower in smokers than in non-smokers. Mean systolic and diastolic blood pressures were significantly lower in smokers than in non-smokers (systolic: 112.06 +/- 15.888 vs 117.25 +/- 17.745 mmHg, respectively, P = 0.000; diastolic: 73.66 +/- 10.084 vs 76.23 +/- 10.458 mmHg, respectively, P = 0.000). The percentage of individuals with 2 MS components was higher in smokers than in non-smokers (39.64% vs 33.00%, respectively, P = 0.000). However, the percentage of non-smokers with 3 MS components was higher than in smokers (49.62 % vs 43.82%, respectively, P = 0.000).
CONCLUSIONSOur findings support the hypothesis that lifestyle factors such as smoking can adversely affect MS components. However, we should acknowledge that these differences may have resulted from the large sample sizes studied and may not be clinically significant. The lower prevalence of some MS components in smokers than in nonsmokers might be because of their lower anthropometric measures.
Adult ; Biomarkers ; blood ; Blood Pressure ; Body Mass Index ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Cross-Sectional Studies ; Diabetes Mellitus ; Female ; Follow-Up Studies ; Humans ; Iran ; epidemiology ; Male ; Metabolic Syndrome ; blood ; epidemiology ; etiology ; Prevalence ; Retrospective Studies ; Smoking ; adverse effects ; blood ; epidemiology ; Triglycerides ; blood ; Waist-Hip Ratio
2.Cheese consumption in relation to cardiovascular risk factors among Iranian adults- IHHP Study.
Masoumeh SADEGHI ; Hossein KHOSRAVI-BOROUJENI ; Nizal SARRAFZADEGAN ; Sedigheh ASGARY ; HamidReza ROOHAFZA ; Mojgan GHARIPOUR ; Firouzeh SAJJADI ; Saman KHALESI ; Mahmoud RAFIEIAN-KOPAEI
Nutrition Research and Practice 2014;8(3):336-341
BACKGROUND/OBJECTIVE: It is expected that dairy products such as cheeses, which are the main source of cholesterol and saturated fat, may lead to the development or increase the risk of cardiovascular and metabolic diseases; however, the results of different studies are inconsistent. This study was conducted to assess the association between cheese consumption and cardiovascular risk factors in an Iranian adult population. SUBJECTS/METHODS: Information from the Isfahan Healthy Heart Program (IHHP) was used for this cross-sectional study with a total of 1,752 participants (782 men and 970 women). Weight, height, waist and hip circumference measurement, as well as fasting blood samples were gathered and biochemical assessments were done. To evaluate the dietary intakes of participants a validated food frequency questionnaire, consists of 49 items, was completed by expert technicians. Consumption of cheese was classified as less than 7 times per week and 7-14 times per week. RESULTS: Higher consumption of cheese was associated with higher C-Reactive Protein (CRP), apolipoprotein A and high density lipoprotein cholesterol (HDL-C) level but not with fasting blood sugar (FBS), total cholesterol, low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and apolipoprotein B. Higher consumption of cheese was positively associated with consumption of liquid and solid oil, grain, pulses, fruit, vegetable, meat and dairy, and negatively associated with Global Dietary Index. After control for other potential confounders the association between cheese intake and metabolic syndrome (OR: 0.81; 96%CI: 0.71-0.94), low HDL-C level (OR: 0.87; 96%CI: 0.79-0.96) and dyslipidemia (OR: 0.88; 96%CI: 0.79-0.98) became negatively significant. CONCLUSION: This study found an inverse association between the frequency of cheese intake and cardiovascular risk factors; however, further prospective studies are required to confirm the present results and to illustrate its mechanisms.
Adult
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Apolipoproteins
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Blood Glucose
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C-Reactive Protein
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Edible Grain
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Cheese*
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Cholesterol
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Cholesterol, HDL
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Cholesterol, LDL
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Cross-Sectional Studies
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Dairy Products
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Dyslipidemias
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Fasting
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Fruit
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Heart
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Hip
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Humans
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Male
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Meat
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Metabolic Diseases
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Surveys and Questionnaires
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Risk Factors*
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Triglycerides
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Vegetables