1.Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder.
Izabela G BARBOSA ; Gabriela Neves VAZ ; Natalia Pessoa ROCHA ; Rodrigo MACHADO-VIEIRA ; Marcio Rogerio Diniz VENTURA ; Rodrigo B HUGUET ; Moises E BAUER ; Michael BERK ; Antônio L TEIXEIRA
Clinical Psychopharmacology and Neuroscience 2017;15(3):269-275
OBJECTIVE: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD. METHODS: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA. RESULTS: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. CONCLUSION: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
Apoptosis
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Bipolar Disorder*
;
Comorbidity
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Depression
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Enzyme-Linked Immunosorbent Assay
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Humans
;
Inflammation
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Plasma*
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Receptors, Tumor Necrosis Factor
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TNF-Related Apoptosis-Inducing Ligand
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Tumor Necrosis Factor-alpha*