1.Effect of Sodium Metavanadate Supplementation on Lipid and Glucose Metabolism Biomarkers in Type 2 Diabetic Patients
Mohammad Afkhami-Ardekani ; Mahdi Karimi ; Seid Mohammad Mohammadi ; Forough Nurani
Malaysian Journal of Nutrition 2008;14(1):113-119
Type 2 diabetes mellitus is a chronic, progressive illness that causes considerable morbidity and premature mortality. Vanadium is a trace mineral that has been
claimed to be effective in controlling blood glucose levels in diabetic patients. A randomised placebo-controlled study was conducted to evaluate the effect of
sodium metavanadate on selected biochemical markers in type 2 diabetic patients. Forty patients were enrolled and half of them received 100 mg sodium
metavanadate daily for 6 weeks while the other half were placebo subjects. The mean age of the patients was 53.1 ± 8.5 years. Body mass index (BMI), blood
pressure(BP), fasting blood sugar (FBS), 2-h postprandial glucose, glycated hemoglobin (HbA1C), triglyceride(TG), total cholesterol (TC), low-density
lipoproteins (LDL), high-density lipoproteins (HDL) were determined before the start and at the end of the study. Levels of FBS, HbA1C, TC and LDL in the
diabetic subjects decreased after six weeks on sodium metavanadate, but the differences were not statistically significant on comparing between pre- and posttrial
levels. Based on the results, this study did not find sodium metavanadate of beneficial use as a form of vanadium supplementation among patients with type
2 diabetes.
2.Determining the frequency of dry eye in computer users and comparing with control group
Davari Hossein MOHAMMAD ; Karimi GHASEM ; Sajjadi Hamid SEYED
International Eye Science 2017;17(8):1410-1414
AIM: To determine the frequency of dry eye in computer users and to compare them with control group.METHODS: This study was a case control research conducted in 2015 in the city of Birjand.Sample size of study was estimated to be 304 subjects (152 subjects in each group,computer user group and control group).Non-randomized method of sampling was used in both groups.Schirmer test was used to evaluate dry eye of subjects.Then,subjects completed questionnaire.This questionnaire was developed based on objectives and reviewing the literature.After collecting the data,they were entered to SPSS Software and they were analyzed using Chi-square test or Fisher`s test at the alpha level of 0.05.RESULTS: In total,304 subjects (152 subjects in each group) were included in the study.Frequency of dry eyes in the control group was 3.3% (5 subjects) and it was 61.8% in computer users group (94 subjects).Significant difference was observed between two groups in this regard (P<0.001).The frequency of eye symptoms in the control group was 7.9% (n=12),and it was 34.2% in computer users group (n=52),which significant difference was observed between two groups in this regard (P<0.001).Frequency of dry eye syndrome in computer users by gender and age groups showed no significant correlation in this regard (P=0.8).The mean working hour with computer per day in patients with dry eye was 6.65±3.52h,while it was 1.62±2.54h in healthy group (T=13.25,P<0.001).CONCLUSION: This study showed a significant relationship between using computer and dry eye and ocular symptoms.Thus,it is necessary that officials need to pay particular attention to working hours with computer by employees.They should also develop appropriate plans to divide the working hours with computer among computer users.However,due to various confounding factors,it is recommended that these factors to be controlled in future studies.
3.Evaluation of the Influence of Changes in Bone Mineral Density and Increases in Articular Cartilage Thickness on Blood Supply of the Femoral Head in Legg–Calvé–Perthes Disease
Hamid Reza FARPOUR ; Mohammad Taghi KARIMI ; Mohammad Hossein KARIMI
Hip & Pelvis 2025;37(1):38-44
Purpose:
Although the etiology of Legg–Calvé–Perthes disease (LCPD) is not well understood, based on a new theory, it may be caused by a decrease in the supply of blood to the femoral head. The objective of this study was to examine the effects of a decrease in bone mineral density (BMD) and an increase in thickness of articular cartilage on the supply of blood to the femoral head in this group of patients.
Materials and Methods:
This case study was based on a simulation analysis. Computed tomography scan images of a subject with Perthes disease were used to create a three-dimensional model of the hip joint on both the normal and Perthes sides. In addition, modeling of the blood vessels of the femoral head, including the foveolar and retinacular arteries, was performed during this study.
Results:
Increased stress on all articular components (femoral head, acetabulum, articular cartilage, and blood vessels) was observed on the Perthes side compared to the normal side. On the Perthes side with normal articular cartilage thickness, stress on all components, particularly the femur, showed a significant increase compared to the normal side.
Conclusion
Increased deformation of the femoral head vessels was observed in patients with Perthes condition and when increased thickness of the articular cartilage was observed. A decrease in BMD can evidently increase the stress applied to the arteries of the femoral head, ultimately leading to death of the femoral head.
4.Evaluation of the Influence of Changes in Bone Mineral Density and Increases in Articular Cartilage Thickness on Blood Supply of the Femoral Head in Legg–Calvé–Perthes Disease
Hamid Reza FARPOUR ; Mohammad Taghi KARIMI ; Mohammad Hossein KARIMI
Hip & Pelvis 2025;37(1):38-44
Purpose:
Although the etiology of Legg–Calvé–Perthes disease (LCPD) is not well understood, based on a new theory, it may be caused by a decrease in the supply of blood to the femoral head. The objective of this study was to examine the effects of a decrease in bone mineral density (BMD) and an increase in thickness of articular cartilage on the supply of blood to the femoral head in this group of patients.
Materials and Methods:
This case study was based on a simulation analysis. Computed tomography scan images of a subject with Perthes disease were used to create a three-dimensional model of the hip joint on both the normal and Perthes sides. In addition, modeling of the blood vessels of the femoral head, including the foveolar and retinacular arteries, was performed during this study.
Results:
Increased stress on all articular components (femoral head, acetabulum, articular cartilage, and blood vessels) was observed on the Perthes side compared to the normal side. On the Perthes side with normal articular cartilage thickness, stress on all components, particularly the femur, showed a significant increase compared to the normal side.
Conclusion
Increased deformation of the femoral head vessels was observed in patients with Perthes condition and when increased thickness of the articular cartilage was observed. A decrease in BMD can evidently increase the stress applied to the arteries of the femoral head, ultimately leading to death of the femoral head.
5.Evaluation of the Influence of Changes in Bone Mineral Density and Increases in Articular Cartilage Thickness on Blood Supply of the Femoral Head in Legg–Calvé–Perthes Disease
Hamid Reza FARPOUR ; Mohammad Taghi KARIMI ; Mohammad Hossein KARIMI
Hip & Pelvis 2025;37(1):38-44
Purpose:
Although the etiology of Legg–Calvé–Perthes disease (LCPD) is not well understood, based on a new theory, it may be caused by a decrease in the supply of blood to the femoral head. The objective of this study was to examine the effects of a decrease in bone mineral density (BMD) and an increase in thickness of articular cartilage on the supply of blood to the femoral head in this group of patients.
Materials and Methods:
This case study was based on a simulation analysis. Computed tomography scan images of a subject with Perthes disease were used to create a three-dimensional model of the hip joint on both the normal and Perthes sides. In addition, modeling of the blood vessels of the femoral head, including the foveolar and retinacular arteries, was performed during this study.
Results:
Increased stress on all articular components (femoral head, acetabulum, articular cartilage, and blood vessels) was observed on the Perthes side compared to the normal side. On the Perthes side with normal articular cartilage thickness, stress on all components, particularly the femur, showed a significant increase compared to the normal side.
Conclusion
Increased deformation of the femoral head vessels was observed in patients with Perthes condition and when increased thickness of the articular cartilage was observed. A decrease in BMD can evidently increase the stress applied to the arteries of the femoral head, ultimately leading to death of the femoral head.
6.Investigation of the range of motion of the shoulder joint in subjects with rotator cuff arthropathy while performing daily activities
Mohammad Taghi KARIMI ; Sahar KHADEMI
Clinics in Shoulder and Elbow 2021;24(2):88-92
Background:
Patients who have rotator cuff arthropathy experience a limited range of motion (ROM) of the shoulder joint and experience problems in performing their daily activities; however, no evidence is available to suggest the exact ROM of the shoulder joint in this population. Therefore, this study sought to determine the degree of motion of the shoulder joint in three planes during different activities.
Methods:
Five subjects with rotator cuff injuries participated in this study. The motion of the shoulder joints on both the involved and normal sides was assessed by a motion analysis system while performing forward abduction (task 1), flexion (task 2), and forward flexion (task 3). The OpenSIM software program was used to determine the ROM of the shoulder joints on both sides. The difference between the ranges of motion was determined using a two-sample t-test.
Results:
The ROMs of the shoulder joint in task 1 were 35°±16.5°, 72.1°±2.6°, and 103.9°±28.7° degrees for flexion, abduction, and rotation, respectively, on the normal side and 28°±19.8°, 31°±31.56°, and 48°±33.5° on the involved side (p<0.05). There was no significant difference between the flexion/extension and rotation movements of the shoulder joint when performing task 1. However, the difference between flexion and rotation movements of the shoulder joints for the second task was significant (p˃0.05).
Conclusions
Those with rotator cuff arthropathy have functional limitations due to muscle weakness and paralysis, especially during the vertical reaching task. However, although these individuals have decreased ROM for transverse reaching tasks, the reduction was not significant.
7.Investigation of the range of motion of the shoulder joint in subjects with rotator cuff arthropathy while performing daily activities
Mohammad Taghi KARIMI ; Sahar KHADEMI
Clinics in Shoulder and Elbow 2021;24(2):88-92
Background:
Patients who have rotator cuff arthropathy experience a limited range of motion (ROM) of the shoulder joint and experience problems in performing their daily activities; however, no evidence is available to suggest the exact ROM of the shoulder joint in this population. Therefore, this study sought to determine the degree of motion of the shoulder joint in three planes during different activities.
Methods:
Five subjects with rotator cuff injuries participated in this study. The motion of the shoulder joints on both the involved and normal sides was assessed by a motion analysis system while performing forward abduction (task 1), flexion (task 2), and forward flexion (task 3). The OpenSIM software program was used to determine the ROM of the shoulder joints on both sides. The difference between the ranges of motion was determined using a two-sample t-test.
Results:
The ROMs of the shoulder joint in task 1 were 35°±16.5°, 72.1°±2.6°, and 103.9°±28.7° degrees for flexion, abduction, and rotation, respectively, on the normal side and 28°±19.8°, 31°±31.56°, and 48°±33.5° on the involved side (p<0.05). There was no significant difference between the flexion/extension and rotation movements of the shoulder joint when performing task 1. However, the difference between flexion and rotation movements of the shoulder joints for the second task was significant (p˃0.05).
Conclusions
Those with rotator cuff arthropathy have functional limitations due to muscle weakness and paralysis, especially during the vertical reaching task. However, although these individuals have decreased ROM for transverse reaching tasks, the reduction was not significant.
8.Toe-in Gait, Associated Complications, and Available Conservative Treatments: A Systematic Review of Literature
Journal of Korean Foot and Ankle Society 2023;27(1):17-23
Purpose:
Toe-in gait is defined as a style of walking in which the foot turns inward. It may be caused by an increase in femoral bone anteversion, tibia torsion, and metatarsus adductus. There are some conservative treatment approaches used to correct this condition. This review aimed to determine the effects of the toe-in gait on joint loading, kinematics, and kinetic parameters while walking. Moreover, it sought to determine the efficiency of various conservative treatments used to correct the condition.
Materials and Methods:
A literature search was conducted in the following databases: PubMed, Institute for Scientific Information (ISI), Web of Science database, EBSCO, and Embase, using the following keywords in toe, toe-in, toeing, in-toe, pigeon toe, and conservative treatment published between 1950 and 2021. The quality of the studies was evaluated using the Down and Black tool.
Results:
A total of 13 papers on the impact of toe-in gait on joint contact force, kinematics, kinetic parameters, and conservative approaches to management were found. The quality of the studies varied between a score of 11 and 22. The toe-in gait influences the joint contact forces and kinematics of the joints, especially the hip and pelvis. The effects of conservative treatment on the toe-in gait appear to be controversial.
Conclusion
As the toe-in gait influences the joint contact force, it may increase the incidence of degenerative joint diseases. Therefore, treatment is recommended. However, there is no strong evidence on the efficacy of conservative treatments, and there are no recommendations for the use of these treatments in subjects with toe-in gait.
9.The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review
Mohammad Amin AMINI ; Masoud KARIMI ; Seyed Saman TALEBI ; Hossein PIRI ; Jamshid KARIMI
Chonnam Medical Journal 2022;58(3):91-95
Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-α and NF-κB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-κB pathway in the cells, furthermore, TNF-αcan arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-α and NF-κB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder.
10.Effects of counter torque and transposition (transfer) of installed implants timing on their integration in dog tibia.
Mohammad Reza KARIMI ; Shima FATHI ; Farzin GHANAVATI
The Journal of Advanced Prosthodontics 2015;7(1):62-68
PURPOSE: The purpose of this research was to evaluate the amount of reosseointegration after counter torquing (reverse torque) and transposing the installed implants at different times. MATERIALS AND METHODS: This study was done on ten tibiae of five cross-bred dogs. At the first day one implant was installed in each tibia. After one week half of the implants were randomly counter torqued (1WCT) and the other half were explanted and reimplanted in a new juxtaposition site (transposed)(1WT). At the same time three new implants were installed in each dog, one of them was considered as one week control (1WC) and remaining two as 8 week groups (8WCT&8WT). After eight weeks the 1WCT and 1WT implants were loosened by counter torque and the quantity of needed force for liberation was measured with the digital device (BGI). At the same time one implant was installed in each dog as eight week control (8WC) and the same protocol was repeated for 8 week groups after another 8 weeks. RESULTS: All implants were osseointegrated. Mean quantities of osseointegration in case groups indicated better amounts rather than control groups. CONCLUSION: Counter torque or transposition of the installed implants one week or eight weeks after the implantation did lead to osseointegration.
Animals
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Dogs*
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Osseointegration
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Tibia*
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Torque*