Introduction: Job burnout is a common phenomenon in health care employees who need to deal with and witness people’s problems and expectations. By definition, occupational cognitive failures appear as problems in performing daily tasks like forgetting them or having difficulty in focusing on them. The present study is an attempt to investigate the relationship between job burnout and occupation cognitive failures in nurses of educational hospitals. Methods: This descriptive-analytic study was done in 2018 and consisted of nurses from the Ardebil Hospital (n= 2,250). Using the Cochran formula, 328 hospital nurses were selected from different units by simple random sampling method. The data were collected by two professional health experts through interviewing and completing demographic questionnaires, job burnout questionnaire, and occupational cognitive failure questionnaire. Statistical analyses was performed in SPSS19. Results: A total of 328 nurses participated in the study. The mean age of the subjects was 34±8 years, varying from 22 years to 58 years. Occupational cognitive failures increased with the increase in emotional exhaustion and depersonalization; while it decreased with an increase in individual accomplishment. Conclusion: There was a significant relationship between occupational cognitive failure and different dimensions of job burnout. In addition, different dimensions of job burnout (Emotional Exhaustion, Depersonalization, and Personal accomplishment) could be associated with possible errors in information processing (memory, attention, and functioning).