Diabetes has become a chronic disease endangering people’s health all over the world. This translated into a huge economic burdento society. Diabetic foot ulcer is difficult to heal due to ischemia, infection, neuropathy and other reasons, which leads to increased risk of amputation and infectious death. Amputation is the main method in traditional treatment, which is adverse to improve the quality of patients’ lives. Thus, more and more scientists pay attention to the treatment of diabetic foot with mesenchymal cells. In this article, we will give a general introduction to the multi-functional mesenchymal stromal cells and explain the mechanism of their use in diabetic foot ulcer, as well as introduce several cases of clinical and preclinical studies on the application of mesenchymal cells in the treatment of diabetes ulcers in foreign countries.

Diabetes has become a chronic disease endangering people’s health all over the world. This translated into a huge economic burdento society. Diabetic foot ulcer is difficult to heal due to ischemia, infection, neuropathy and other reasons, which leads to increased risk of amputation and infectious death. Amputation is the main method in traditional treatment, which is adverse to improve the quality of patients’ lives. Thus, more and more scientists pay attention to the treatment of diabetic foot with mesenchymal cells. In this article, we will give a general introduction to the multi-functional mesenchymal stromal cells and explain the mechanism of their use in diabetic foot ulcer, as well as introduce several cases of clinical and preclinical studies on the application of mesenchymal cells in the treatment of diabetes ulcers in foreign countries.