Objective To explore the effect of nest-type care combines with non-nutritive sucking on the growth and development of low birth weight infant.Methods According to whether supplemented the" nest"type of care and non-nutritive sucking,totals of 160 cases of low birth weight infants were divided into the observation group( n =80) received the nest-type care combines with non-nutritive sucking,and the control group( n =80) received traditional nursing.Then,the growth,the occurrence of feeding intolerance,the ease of breathing pauses of infant were observed.Results The average time of infant in the observation group returned to birth weight was (4.± 0.6) days four days significantly shorter than (7.2 ± 2.3) days in the control group (t =11.29,P＜0.01 ).The seventh and fourteenth days after admitted to hospital,the weight of infant in observation group were respectively ( 106.0 ± 12.2),(299.7± 3.4) g,which increased significantly faster than that in the control group respectively ( 31.0 ± 16.5 ),(235.3 ± 0.5 ) g,and the difference was statistically significant (P＜0.01 ).Sleep time of seventh and fourteenth days after admitted were respectively (20.6 ±2.4) hours and (20.4 ±1.8 ) hours,which was better than that in the control group ( 19.2 ± 2.2 ) hours and ( 19.1 ± 1.2) hours,and the difference was statistically significant ( t =3.85,5.37,respectively; P ＜ 0.01 ).The occurrence of feeding intolerance such as gastric retention,abdominal distension,vomiting,and apnes cases in the observation group significantly lower than that in the control group ( x2 =14.41,P ＜ 0.01 ).Conclusions Nesttype care combines with non-nutritive sucking make low birth weight infant feelling warmth and safety,It can improve the tolerance of enteral feeding,accelerate physical growth,and promote the low birth weight infant to grow and development.

OBJECTIVESTo confirm previous whole-genome scan results of mapping type 2 diabetes susceptibility genes in chromosome 1 in Northern Chinese Han population by conducting a new genome scan with both an enlarged number of type 2 diabetes families and a new set of microsatellite markers.

METHODSA genome scan method was applied. After multiplexed PCR, electrophoreses, genescan and genotyping analysis, size informations for all loci were obtained, and a further study was done using both parametric and non-parametric linkage analysis to calculate the P-values and Z-values of these loci.

RESULTSA total of 34 microsatellite markers distributed within 5 regions along chromosome 1 were surveyed, and 12,000 genotypes were screened. Evidence of linkage with diabetes was identified for 8 of the 34 loci (all the P-values of the 8 loci distributed in 3 regions were lower than 0.05, and the highest Z-value was 2.17). Interestingly, all the 5 markers at the P terminal 1p36.3-1p36.23 region, spanning a long range of 16.9 cM, suggested to be linked with the disease. The results of the other two regions were not consistent with the previous ones.

CONCLUSIONSThe study results have confirmed those gained in the previous genome-wide scan. The fact that all 5 loci at the P terminal region displayed linkage with diabetes suggests that more than 1 susceptibility gene may reside in this region.

Asian Continental Ancestry Group ; Chromosome Mapping ; Chromosomes, Human, Pair 1 ; Diabetes Mellitus, Type 2 ; genetics ; Ethnic Groups ; Genetic Linkage ; Genetic Predisposition to Disease ; Genetic Testing ; Genotype ; Humans ; Microsatellite Repeats ; genetics