Objective To explore the veracity and practical value of multi-slice spiral CT in the diagnosis of nasal bone fractures.Methods 28 patients suffered from facial trauma were thin layer scanned by multi-slice spiral CT,then three-dimensional reconstruction imaging could stereoscopically and directly show the nasal bone fracture.Results The 3D reconstruction could indicate the nasal bone fracture location,shape,range and type.Conclusions The 3D reconstruction imaging with multi-slice spiral CT has high value in diagnosis of nasal bone fracture and showing space relationship.

The number of medical device adverse events reported to national monitoring center increased greatly year by year, but the reporting system still existed some deficiencies which resulting in confusion when filling the forms, especially those selections about relationship evaluation. This paper proposed amendments about event-evaluation process according to the characteristics of medical device adverse events reported in China, in order to perform timely and effectively regulation on different types of adverse events for different purposes.
China ; Consumer Product Safety ; Equipment and Supplies ; Safety Management

Glaucoma,optical neuritis and trauma are optic nerve injury-related diseases.These ocular diseases cause irreversible damage of the vision and even blindness.The study on optic nerve regeneration is a powerful approach for rescuing vision and improving the quality of life of patients.Therefore,how to promote optic nerve regeneration is always the focus in ophthalmology.In recent years,great progression has achieved by modulation of cellular signal pathway,usage of glial cells,stem cells and neurotrophic factor,etc,which lays a basis for the treatment of optic nerve injury.Ophthalmologist should trace and participate in these researches to promote the development of regeneration medicine.This review summarizes these new approaches after discussing factors effecting optic nerve regeneration briefly and proposes questions to answer.

Aim To study the effects of chronic morphine treatment on the contents of cAMP and cGMP in sympathetic ganglia,superior cervical ganglia(SCG) of rats.Methods The chronic morphine dependent model of rats was established by subcutaneous injection of morphine in gradually increasing doses for 5 days,the dependence and the tolerance of the model was estimated by naloxone precipitation test and 55℃ tail-flick trail test respectively.The contents of cAMP and cGMP in SCG were detected by means of 125I radioimmunoassay.Results ① Compared with control group,the content of cAMP in SCG of morphine-acute group rats was descended(P0.05;compared with morphine-acute,P0.05).Conclusion There was an up-regulation of cAMP in sympathetic ganglia of chronic morphine treated rats.

Objective To observe the influence of Fibronectin-Thrombopoietin(FN-TPO) gene modified human bone marrow mesenchymal stem cells(MSCs) on the engraftment of cord blood hematopoietic stem cells.Methods FN-TPO gene modified human bone marrow MSCs combined with cord blood mononuclear cells(CB-MNC) were transplanted to sublethal dose treated severe combined immunodeficiency disease(SCID) mice.After transplantation,these mice were observed for 4 weeks.Peripheral blood cell counts were performed at different time point to assay the hematopoietic system status of the mice.Four weeks after the transplantation,human-sourced cell integration was assayed by flow cytometry(FCM) and polymerase chain reaction(PCR).Results One week after the cell transplantation,every main index of the peripheral blood cell counts in the gene modified group was higher than that in the control groups(P

Aim To study effects of morphine tolerance and dependence on the fast excitatory synaptic transmission in sympathetic ganglia of rats.Methods The isolated sympathetic ganglia,superior cervical ganglia(SCG), were made from control and morphine tolerant and dependent rats respectively.Effects of morphine tolerance and dependence on the fast excitatory synaptic transmission in rat sympathetic ganglia were studied by means of intracellular recording technique.Results ① Morphine(0.1～1.0 mmol?L~(-1))reversibly inhibited the amplitude of the fast excitatory postsynaptic potentials(f-EPSPs) in SCG neurons of control rats.② Compared with control group,inhibitory effects of morphine(0.5 mmol?L~(-1) and 1.0 mmol?L~(-1)) on f-EPSPs in SCG neurons of morphine tolerant and dependent rats were obviously decreased;③ Naloxone(0.1 mmol?L~(-1)),which had no significantly effect on f-EPSPs in SCG neurons of control rats,could reversibly facilitate the amplitude of f-EPSPs in SCG neurons of morphine tolerant and dependent rats;④ No significant difference of RMP and Rm was founded between SCG neurons of control and morphine tolerant and dependent rats.Conclusion The morphine tolerant and dependent of the fast excitatory synaptic transmission in rat sympathetic ganglia has been formed in morphine tolerant and dependent rats.

Congenital absence of the lower sternum, defect of the abdominal wall, defects of the anterior diaphragm, pericardial defects and cardiac anomalies had been described as a syndrome by Cantrell et al. Developing mechanism of the syndrome was embryologically defined. These defects arise apparently from combined anomalies of developing of the dorsal mesoderm. The authors present two cases of Cantrell's syndrome developed in one day old and eight months old female patient in which angiocardiography was done at the Department of Radiology, Seoul National University Hospital.
Abdominal Wall ; Angiocardiography ; Diaphragm ; Female ; Humans ; Mesoderm ; Seoul ; Sternum

Leukemia is the commonest malignancy in childhood, accounting for about one-third of all malignancies in thosebelow the age of 15 years. Authors analysed the chest PA findings of 177 cases of leukemia in childhood below theage of 15 years, diagnosed at Seoul National University Hospital in recent 5 years since 1978. The summaries ofthe analysis are as follows; 1. Among 177 cases, 121 cases were male and 56 cases were female. The malepredominant than the female with the ratio of 2.2:1. In 177 cases, 77% of the patients were under the 10 years ofage. 2. The incidence of subtype of leukemia was as follows; The acute form was 158 cases (89%), acute lymphocyticleukemia, 55%, acut myelocytic group, 31.6%, chronic myelocytic type, 10%. And acute lymphocytic leukemia was61.4% of acute form. 3. The incidence of abnormality in chest PA was 32.2%(57 cases) . Among these 57 cases,abnormality in lung field was 35 cases (19.8% of total patients) hilar and mediastinal lymph nodes enlargement was19 cases(10.7%). Pleural effusion was 13 cases (7.3%) and cardiac shadow enlargement in chest PA was 3 cases.
Child ; Female ; Humans ; Incidence ; Leukemia ; Lung ; Lymph Nodes ; Male ; Pleural Effusion ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Seoul ; Thorax

Objective To analyze clinical manifestations, histology, immunohistochemistry (IHC), surgical treatment and prognosis of colorectal stromal tumours. Methods The clinical and pathological data of 30 cases of colorectal stromal tumors were analyzed retrospectively. According to Fletcher proposed approach for defining risk group in GIST, these cases were grouped into VLR, LR, IR and HR.Cox multiple regression multiple factor analysis method was used to evaluate impact factors for prognosis.Results Radical resection was achieved in all 30 cases. Tumors located in the colon in 4 ( 13% ) cases, in the rectum in 20 (67%) cases, and within the anal canal in 6 (20%) cases. C-kit expression was positive in 86. 7% cases as determined by IHC. Postoperatively, 29 cases were followed-up from 4 to 130 mos. The Fletcher proposed approach for defining risk group in GIST was closely related to the survival rates ( B =4. 226,P =0. 02). The 3- and 5-year survival rate was 73% and 53% respectively. Conclusions Surgical resection and molecular target treatment is the treatment of choice for colorectal stromal tumors. The Fletcher's classification of malignancy risk group for colorectal stromal tumors is statistically related to the modus operandi and patients' survival rate.

The paper describes the short and medium term (within 2 to 5 years) priorities that any region in China right now faces in working out and implementing its regional health planning, viz. the coordinated development strategy of medicine and health, medical security and social economy. The authors hold that to achieve the coordinated growth of the health cause and society, it is imperative to overcome in the short run logically related obstacles in four aspects: ineffective solution to the apparent problems followed with interest by both the social and health sectors and lack of effective operating conditions accompanying medical insurance reform, both resulting in the lack of a driving force in the reform within hospitals; difficulty in achieving breakthroughts in the development of the health cause; and the probability of a regional health planning becoming a mere formality because of the above factors. In addition, the fact that reform of medical and health institutions in their setup and ownership of property rights lags behind macroscopic social economic reform obscures the explanation of and solution to the above problems. Based on the research results, the paper sets forth the priorities in short and medium term planning.