Breast ; Carcinoma ; Humans ; Mixed Tumor, Malignant

Endodermal Sinus Tumor ; Female ; Humans ; Mixed Tumor, Malignant ; Neoplasms, Germ Cell and Embryonal ; Teratoma/pathology* ; Uterus/pathology*

A 69-year-old man was referred with left exophthalmos. Computed tomographic (CT) findings detected a well-circumscribed mass in the left side of the intraorbital cavity. At that time, he refused the further evaluation and treatment. About three years later, the size of the mass had enlarged, and the patient's symptoms were getting worse. The mass was completely removed with frontotemporal craniotomy and superolateral orbitotomy. In operative findings, the mass had originated in the lacrimal gland and was well-encapsulated without invasion to the surrounding tissue. In the pathologic findings, the tumor consisted of pleomorphic adenoma with osteosarcomatous change of stromal components. Postoperatively, the adjuvant radiotherapy was done four weeks later. The patient's symptoms were improved. The pleomorphic adenoma with osteosarcomatous change is extremely rare and appropriate treatment is not clearly established. We would like to report this rare case with a review of the literature.
Adenoma, Pleomorphic* ; Aged ; Craniotomy ; Exophthalmos ; Humans ; Lacrimal Apparatus* ; Mixed Tumor, Malignant ; Radiotherapy, Adjuvant ; Sarcoma

Carcinoma exmixed tumor is a mixed tumor in which a second neoplasm develops from the epithelial component that fulfills the criteria for malignancy. This tumor occurs frequently in the parotid glands. Individuals in whom carcinoma ex mixed tumor have a past history of benign mixed tumor. These lesions contain both a benign mixed tumor as well as a malignant neoplasm. We report a case of carcinoma ex mixed tumor which occurred in the parotid gland. A 67-year-old woman presented with movable right mass. she complained pain and facial paralysis. The clinical presentation, several diagnostic images, and histopathologic findings are presented.
Aged ; Facial Paralysis ; Female ; Humans ; Mixed Tumor, Malignant ; Neoplasms, Second Primary ; Parotid Gland*

PURPOSE: To report a case of carcinoma ex pleomorphic adenoma observed during the patient's first operation. CASE SUMMARY: A 63-year-old female presented with proptosis and ptosis that was aggravated 1 year prior. On preoperative CT image, a 32 x 20 x 21 mm-sized well demarcated mass (suspected as pleomorphic adenoma) was observed and was removed entirely by anterolateral orbitotomy. The excised mass surface was uneven but the capsule appeared intact on gross examination. Hard, yellow-colored and soft, dark-colored materials were found concurrently on cross section. The histological examination showed malignant cells as part of the soft material and was diagnosed as carcinoma ex pleomorphic adenoma. CONCLUSIONS: We report a case of carcinoma ex pleomorphic adenoma of the lacrimal gland that presented with malignant change during the patient's first operation. Supposedly, during the process of mass growth, minimal rupture occurred causing malignant transformation. Clinically, although a mass is believed benign based on imaging, the possibility of malignant transformation of a tumor increasing rapidly or enlargement causing development of rapid proptosis should be considered.
Adenoma, Pleomorphic* ; Exophthalmos ; Female ; Humans ; Lacrimal Apparatus ; Middle Aged ; Mixed Tumor, Malignant ; Rupture

No abstract available.
Humans ; Lung Neoplasms/*secondary ; Male ; Mixed Tumor, Malignant/*pathology ; Parotid Neoplasms/*pathology

Carcinoma ex pleomorphic adenoma of the salivary gland is a relatively uncommon tumor that accounts for roughly 4% of all malignancies at this location. The lesion occurs when a malignant tumor arises in the epithelial component of a pleomorphic adenoma. It usually arises in the parotid gland. Typically, it is a high grade carcinoma, frequently leading to metastasis and disease-related death. We experienced a case of a salivary duct carcinoma that arose in the epithelial component of a pleomorphic adenoma in the parotid gland with neck metastasis. After total parotidectomy and modified radical neck dissection, he was given 10, 980 cGy of radiation postoperatively for 7 weeks. The clinicopathologic feature of this tumor are presented with a review of literatures.
Adenoma, Pleomorphic* ; Mixed Tumor, Malignant ; Neck ; Neck Dissection ; Neoplasm Metastasis ; Parotid Gland* ; Salivary Ducts* ; Salivary Glands

Carcinosarcomas of the salivary gland are very rare and demonstrate malignant epithelial and sarcomatous components. Patients of this tumor are usually in their sixties and it most frequently involves the parotid (65%). Carcinosarcomas are considered by most investigators to be aggressive neoplasms with poor survival. We report a case of submandibular gland carcinosarcoma that showed squamous cell carcinoma and fibrosarcoma in a 27-year-old man.
Adult ; Carcinoma, Squamous Cell ; Carcinosarcoma* ; Fibrosarcoma ; Humans ; Mixed Tumor, Malignant ; Research Personnel ; Salivary Glands ; Submandibular Gland*

Carcinosarcomas, also known as true malignant mixed tumors, are rare tumors of the salivary gland and are composed of both malignant epithelial and malignant mesenchymal elements. They may occur in pre-existing pleomorphic adenomas or arise de novo. Here we report the first case of carcinosarcoma of the parotid gland composed of mucoepidermoid carcinoma and osteosarcoma. The tumor had originated from the parotid gland and extended into the parapharyngeal space. To the best of our knowledge, there have been no reports on mucoepidermoid carcinoma mixed with osteosarcoma ex pleomorphic adenoma in the parotid gland.
Adenoma, Pleomorphic ; Carcinoma, Mucoepidermoid ; Carcinosarcoma ; Mixed Tumor, Malignant ; Osteosarcoma ; Parotid Gland ; Salivary Glands

We performed retrospective review of charts in 26 patients who had been confirmed to have lacrimal gland tumor at korea University Guro hospital from March, 1984 to March, 1996 for evaluating the correlation between clinical findings and histopathologic diagnosis. This study was focused on incidence of lacrimal gland tumors, age, sex, symptoms and signs and ists duratio, radiologic findings, presence and location of metastases, and prognosis. There were 6 cases of benign mixed tumor(23%), 6 cases of malignant mixed tumor(23%), 4 cases of adenoid cystic carcinoma(15.4%), 4 cases of inflammatory pseudotumor(15.4%) and 6 cases of pseudolymphoma(23%). The characteristics of clinical findings of malignant lacrimal gland tumor were pain (70%), the duration of symptom less than 6 months (90%) and bony destruction detected in radiologic findings(75% of malignant mixed tumor and 50% of adenoid cystic carcinoma). All cases of malignant tumor patients had local or distant metastasis. Among them, 2 cases of malignant mixed tumor and 2 cases of adenoid cystic carcinoma had pulmonary metastasis and were died of pulmonary metastasis. This study showed good correlations between clinical diagnosis and pathologic diagnosis, and will help in making early diagnosis and treatment of malignant lacrimal gland tumors.
Adenoids ; Carcinoma, Adenoid Cystic ; Diagnosis ; Early Diagnosis ; Humans ; Incidence ; Korea ; Lacrimal Apparatus* ; Mixed Tumor, Malignant ; Neoplasm Metastasis ; Prognosis ; Retrospective Studies