2.RE: Atypical Pulmonary Metastases from Pancreatic Adenocarcinoma.
Edoardo VIRGILIO ; Elsa IANNICELLI ; Genoveffa BALDUCCI
Korean Journal of Radiology 2014;15(3):399-400
No abstract available.
Humans
;
Lung Neoplasms/*secondary
;
Male
;
Mixed Tumor, Malignant/*pathology
;
Parotid Neoplasms/*pathology
3.Pathobiology of ovarian carcinomas.
Mojgan DEVOUASSOUX-SHISHEBORAN ; Catherine GENESTIE
Chinese Journal of Cancer 2015;34(1):50-55
Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). Immunohistochemistry and molecular testing help pathologists to decipher the significant heterogeneity of this disease. Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future.
Carcinoma, Endometrioid
;
pathology
;
Cystadenocarcinoma, Mucinous
;
pathology
;
Cystadenocarcinoma, Serous
;
pathology
;
Female
;
Humans
;
Mixed Tumor, Malignant
;
pathology
;
Neoplasms, Glandular and Epithelial
;
pathology
;
Ovarian Neoplasms
;
genetics
;
pathology
4.Combined Hepatocellular-cholangiocarcinoma.
The Korean Journal of Hepatology 2007;13(4):571-575
5.Mixed Tumor of the Vagina: A Case Report.
Mi Seon KANG ; Hye Kyoung YOON
Journal of Korean Medical Science 2002;17(6):845-848
We report a case of mixed tumor arising in the lower vaginal wall. The patient was a 20-yr-old nullipararous woman. The tumor was relatively well-defined with expansile margin, and showed solid sheets or fascicles of stromal-type spindle cells and ovoid epithelial cells with sparsely scattered nests of mature squamous epithelium and glands lined by mucinous epithelium. Cellular atypia was not conspicuous, however, mitosis was counted upto 6 per 10 high power fields. We examined this tumor immunohistochemically and ultrastructurally and reviewed the articles to identify the histogenesis. Positive reaction for vimenin and cytokeratin of stromaltype spindle cells and presence of desmosome-like structures and tonofilaments on electron microscopic examination suggested the epithelial origin of the stromaltype spindle cells.
Adult
;
Female
;
Humans
;
Immunohistochemistry
;
Keratins/biosynthesis
;
Microscopy, Electron
;
Mitosis
;
Mixed Tumor, Malignant/*diagnosis/pathology/ultrastructure
;
Vagina/*pathology
;
Vaginal Neoplasms/*diagnosis/pathology/ultrastructure
;
Vimentin/biosynthesis
6.Atypical Pulmonary Metastases from a True Malignant Mixed Tumor of the Parotid Gland.
Wen Chiung LIN ; Chao Shiang LI ; Chih Kung LIN ; Hsian He HSU ; Tsun Hou CHANG ; Tom Yun Cheng CHEN ; Guo Shu HUANG
Korean Journal of Radiology 2009;10(2):202-205
A 58-year-old male patient presented with a recurrent true malignant mixed tumor of the parotid gland. Patchy pulmonary opacities were identified with a chest radiograph. Subsequently, a CT scan of the chest showed pulmonary parenchymal consolidation with amorphous calcifications. This abnormality was confirmed to be the result of a metastatic true malignant mixed tumor by using CT-guided biopsy. The current case demonstrated an extremely rare example of atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland showing an air-space pattern and calcification.
Biopsy, Fine-Needle
;
Humans
;
Lung Neoplasms/*secondary
;
Male
;
Middle Aged
;
Mixed Tumor, Malignant/*pathology
;
Parotid Neoplasms/*pathology
;
Radiography, Interventional
;
Tomography, X-Ray Computed
7.Collision tumor of the kidney composed of clear cell carcinoma and collecting duct carcinoma: report of a case with unusual morphology and clinical follow-up.
Rhonda BURCH-SMITH ; Nizar M TANNIR ; Erika RESETKOVA ; Pheroze TAMBOLI ; Priya RAO
Chinese Journal of Cancer 2014;33(7):351-355
We report the case of a 67-year-old female who presented with a large renal mass. Gross examination of the nephrectomy specimen demonstrated a 6-cm renal mass that invaded into the renal sinus and perinephric fat. Histologic examination revealed two distinct tumor types. The first type was a conventional (clear cell) renal cell carcinoma that was of low nuclear grade and comprised the minority of the overall tumor. The second type was a high-grade collecting duct carcinoma with glandular/tubular differentiation and composed the majority of the tumor. Immunohistochemical studies demonstrated distinctive patterns of the two tumor types, thus confirming two distinct lineages. Five months postoperatively, the patient developed metastasis to the lungs and right hilar lymph node region. A fine needle aspiration of a lung nodule demonstrated a metastatic, poorly differentiated carcinoma, similar to the collecting duct carcinoma component in the kidney. Collision tumors of the kidney are rare with fewer than 10 cases reported in the literature. Our report further expands the spectrum of this rare phenomenon.
Aged
;
Biopsy, Fine-Needle
;
Carcinoma, Renal Cell
;
pathology
;
Female
;
Follow-Up Studies
;
Humans
;
Kidney Neoplasms
;
Lung Neoplasms
;
secondary
;
Lymphoma
;
Mixed Tumor, Malignant
8.Clinicopathologic features of combined hepatic carcinoma.
Cai HE ; Hong-fang YIN ; Ping LIU ; Ying ZHANG ; Jian-bo ZHANG
Chinese Journal of Pathology 2013;42(12):824-828
OBJECTIVETo investigate clinicopathological features of combined hepatocellular-cholangiocarcinoma (C-HCC-CC) with neuroendocrine carcinoma (NEC) differentiation and to review the literature.
METHODSThe clinical data, histological manifestations and immunohistochemical staining results of two cases of C-HCC-CC were analyzed along with a review of the current literature.
RESULTSBoth patients were male with an average age of 57.5 years. Both patients were positive for hepatitis B virus antigen. The tumors of both cases demonstrated the following 3 unequivocal mixed elements: (1) polygonal epithelial tumor cells growing in nests or trabeculae with positive staining for Hepatocyte and AFP, diagnostic of hepatocellular carcinoma (HCC). Cytoplasmic bile production was present in the tumor cells in one case; (2) elliptic or short spindle-shape small blue tumor cells growing in nests or organoid pattern with Syn/CgA/CD56 positivity confirming the presence of neuroendocrine carcinoma (NEC) component; (3) oval tumor cells growing in nests or glandular forms with positivity of CK19 and CK7 confirming differentiation of cholangiocarcinoma (CC). In both cases, the tumors contained at least 20% of each of HCC, NEC and CC components.
CONCLUSIONC-HCC-CC with NEC is a rare form of primary malignancy of the liver with a poor prognosis.
Bile Duct Neoplasms ; Bile Ducts, Intrahepatic ; Bone Neoplasms ; secondary ; CD56 Antigen ; metabolism ; Carcinoma, Hepatocellular ; metabolism ; pathology ; therapy ; Carcinoma, Neuroendocrine ; metabolism ; pathology ; therapy ; Chemoembolization, Therapeutic ; Cholangiocarcinoma ; metabolism ; pathology ; therapy ; Chromogranin A ; metabolism ; Humans ; Immunohistochemistry ; Keratin-19 ; metabolism ; Keratin-7 ; metabolism ; Ki-67 Antigen ; metabolism ; Liver Neoplasms ; metabolism ; pathology ; therapy ; Male ; Middle Aged ; Mixed Tumor, Malignant ; metabolism ; pathology ; therapy ; Synaptophysin ; metabolism ; alpha-Fetoproteins ; metabolism
9.Clear cell renal cell carcinoma with neuroendocrine differentiation and liver metastasis: report of a case.
Linke YANG ; Dianbin MU ; Yinping YUAN ; Dexian ZHANG ; Jujie SUN ; Shuping CAI ; Yongsheng GAO
Chinese Journal of Pathology 2014;43(4):278-279
Adult
;
Carcinoma, Neuroendocrine
;
metabolism
;
pathology
;
surgery
;
Carcinoma, Renal Cell
;
metabolism
;
pathology
;
surgery
;
Chromogranin A
;
metabolism
;
Female
;
Humans
;
Keratin-7
;
metabolism
;
Keratin-8
;
metabolism
;
Kidney Neoplasms
;
metabolism
;
pathology
;
surgery
;
Liver Neoplasms
;
secondary
;
Mixed Tumor, Malignant
;
metabolism
;
pathology
;
surgery
;
Nephrectomy
;
Neprilysin
;
metabolism
;
Synaptophysin
;
metabolism
;
Vimentin
;
metabolism